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A synthetic medium for the biosynthesis of oleandomycin

A synthetic medium for the biosynthesis of oleandomycin

Antibiotiki 10(6): 502-507

Potassium nitrate was the best N source for the biosynthesis of oleandomycin by Actinomyces antibioticus, strain LS[long dash]01[long dash]1790. Potassium phosphate (60 mg %) was optimal for the biosynthesis of oleandomycin. A 2- or 3-fold increase in the K3(PO4) concentration suppressed the production of oleandomycin only slightly as compared to the optimal concentration. The presence of P during the biosynthesis phase had no negative effect on the oleandomycin accumulation. Enrichment of the medium with glucose (3 and 5%) and a simultaneous increase in the KNO3 content (0.75-1%) mainly favored the mycelium growth and not the oleandomycin biosynthesis. A simple synthetic medium for growth was developed.

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Accession: 068622392

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PMID: 5854539

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