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Conversion of progesterone to 16-alpha-hydroxyprogesterone in normal human corpus luteum tissue

Conversion of progesterone to 16-alpha-hydroxyprogesterone in normal human corpus luteum tissue

Steroids 10(2): 107-114

Although the conversion of progesterone to 16[alpha]-hydroxy-progesterone has been reported in human endocrine target organs, information of 16-hydroxylase activity on the ovarian tissue is quite limited. Warren and Salhanick observed formation of 16[alpha]-hydroxy-progesterone on incubation studies with minced tissues from both normal and Stein-Leventhal ovaries; however, the normal ovaries used in their experiments contained no corpus luteum. Evidence is presented, in this manuscript, that progesterone-7H3 was converted to radioactive 16[alpha]-hydroxyprogesterone by a human corpus luteum removed on the 26th day of the menstrual cycle.

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Accession: 068625464

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PMID: 6058013

DOI: 10.1016/0039-128x(67)90074-8

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