EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Effect of norepinephrine on the pituitary adrenocorticotrophic activation by ether stress and on the in vitro release of ACTH by the adenohypophysis of male and female newborn rats


Effect of norepinephrine on the pituitary adrenocorticotrophic activation by ether stress and on the in vitro release of ACTH by the adenohypophysis of male and female newborn rats



Neuroendocrinology 39(2): 105-113



ISSN/ISBN: 0028-3835

PMID: 6089018

DOI: 10.1159/000123965

The effect of norepinephrine (NOR) has been investigated in 8-day-old newborn rats of both sexes subjected to stress by 2 min ether inhalation or sham stress. The animals were sacrificed either before or 2 and 32 min after the stress or the sham stress procedure was started. Investigations were also performed on newborns bearing neurotoxic lesions of the arcuate nucleus by neonatal treatment with monosodium-L-glutamate. The effect of NOR was also investigated in vitro on incubated pars distalis. ACTH concentrations in the pituitary, plasma, and the incubation medium were determined by radioimmunoassay. NOR at the dose of 0.2 microgram/g was unable to affect plasma ACTH levels during a period of 60 min in unstressed newborns, in contrast to higher doses (0.5, 1, and 5.0 micrograms/g) which elicited a sharp rise in plasma ACTH levels. Then, NOR was injected (0.2 microgram/g) to male and female pups 15 min before the stress or sham stress procedure. 32 min after the beginning of ether inhalation, the pituitary response was greater in NOR-injected than in saline-injected males; in NOR-treated females the rise in plasma ACTH levels was higher at 2 and 32 min than in saline-injected animals. At this latter time, plasma ACTH levels were similar in NOR-treated males and females, while in saline-treated newborns, the response to ether stress was greater and more longlasting in females than in males. No significant rise in plasma ACTH levels was observed in sham-stressed pups.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 068625974

Download citation: RISBibTeXText

Related references

Effect of Norepinephrine on the Pituitary Adrenocorticotrophic Activation by Ether Stress and on the in vitro Release of Acth by the Adenohypophysis of Male and Female Newborn Rats. Neuroendocrinology 39(2): 105-113, 2008

Influence of acute intracerebroventricular (i.c.v.) administration of adrenocorticotrophin (ACTH) on LH secretion in male rats: effect of pretreatment (i.c.v.) with ACTH antiserum on the serum LH response to an acute ether stress. Journal of Endocrinology 108(2): 275-280, 1986

Effect of neuropeptide Y and norepinephrine on vasopressin release in male and female rats. FASEB Journal 8(4-5): A823, 1994

Ghrelin stimulates adrenocorticotrophic hormone (ACTH) secretion by human ACTH-secreting pituitary adenomas in vitro. Journal of Neuroendocrinology 19(3): 208-212, 2007

Pituitary-adrenal response in male rats subjected to continuous ether stress and the effect of dexamethasone treatment. Journal of Endocrinology 75(2): 325-326, 1977

Effect of copulation on the release of pituitary gonadotropins in male and female rats. Endocrinology 79(1): 49-54, 1966

Effect of hypothalamic lesion on stress induced changes of pituitary hormones(1)--plasma ACTH after ether-laparotomy stress--. Horumon to Rinsho. Clinical Endocrinology 27(4): 385-388, 1979

Effect of prostaglandin E2 on ACTH and beta-endorphin release from rat adenohypophysis in vitro after secretagogues which can mimic various first or second messengers. Naunyn-Schmiedeberg's Archives of Pharmacology 333(2): 149-155, 1986

Prolactin released in vitro from the pituitary of lactating, pregnant, and steroid-treated female or male rats stimulates prolactin secretion from pituitary lactotropes of male rats. Neuroendocrinology 91(1): 77-93, 2010

Experimental studies on the effects of hypothalamic lesions on the control of ACTH release from the adenohypophysis in rats. II. Morphological observations on the structures and functions of the adenohypophysis and the adrenal cortex of rats with hypothalamic lesions. Naika Hokan. Japanese Archives of Internal Medicine 8: 791-804, 1961

Effect of small doses of oestradiol benzoate on pituitary production and release of I.C.S.H. in gonadectomized male and female rats. Acta Endocrinologica 39: 245-252, 1962

The effect of ethyl alcohol on secretion of the adrenocorticotrophic hormone of the pituitary gland in rats. Notes on the mechanism of control of the secretion of ACTH. Physiol Bohemosl 6(4): 516-522, 1957

Effect of inhibin-like activity on LH-RH-stimulated release of FSH by pituitary glands from female rats in vitro. Life Sciences 32(10): 1091-1098, 1983

Receptive female rats stimulate norepinephrine release from olfactory bulbs of freely behaving male rats. Neuroendocrinology 49(1): 28-32, 1989

Effect of cycloheximide in vitro on LHRH-induced release of LH from the anterior pituitary of male rats. Acta Endocrinologica, Denmark 84(Suppl. 208): 18-20, 1977