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Reproduction and immunogenic properties of recombinant and parent strains of influenza virus



Reproduction and immunogenic properties of recombinant and parent strains of influenza virus



Medycyna Doswiadczalna i Mikrobiologia 33(2): 115-118



Experiments were performed with recombinants MRC-12 [derived from A/Scotland/840/74 (H3N2) and A/PR/8/34 (HoN1)] and X-47 [derived from A/Victoria/3/75 (H3N2) and A/PR/8/34 (HoN1)] and the corresponding parent strains. Infectious and hemagglutination titers were determined in embryonated eggs, HI [hemagglutination-inhibition] antibody titers were determined in sera of mice immunized with equivalent doses of the strains tested and antigenic analysis was performed by cross HI test. The recombinants were found to have reproduction titers higher by 2-3 log as compared with parent strains, while their immunogenicity was similar or lower. The recombinants are antigenically less specific than the parent strains.

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Accession: 068628957

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PMID: 6170847


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