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Study of Epstein Barr virus (EBV) antibodies: IgG and IgM anti-VCA, IgG anti-EA and Ig anti-EBNA obtained with an original microtiter technique: --serological criterions of primary and recurrent EBV infections and follow-up of infectious mononucleosis--seroepidemiology of EBV in Belgium based on 5178 sera from patients



Study of Epstein Barr virus (EBV) antibodies: IgG and IgM anti-VCA, IgG anti-EA and Ig anti-EBNA obtained with an original microtiter technique: --serological criterions of primary and recurrent EBV infections and follow-up of infectious mononucleosis--seroepidemiology of EBV in Belgium based on 5178 sera from patients



Acta Clinica Belgica 37(5): 281-298



An original microtiter immunofluorescence technique was used to titrate EBV [Epstein-Barr virus] antibodies of IgG and IgM anti-VCA [viral capsid antigen], IgG anti-EA [early antigen] Ig anti-EBNA [Epstein-Barr nuclear antigen]. Compared were 307 sera from infectious mononucleosis (IM) patients and 323 controls for IgG anti-VCA, -EA and Ig anti-EBNA antibodies. IgM anti-VCA antibodies were titrated in 112 cases of IM and in 50 healthy control; 26 cases of IM were followed up to 6 mo. after onset. A high IgG anti-VCA titer of .gtoreq. 1:256 was not a reliable criterion of EBV primary infection. In the 1st mo. of IM, 94% of patients had an anti-EA titer .gtoreq. 1:8 and 85% had a titer of .gtoreq. 1:32; an anti-EA titer of .gtoreq. 1:32 was indicative of primary or secondary active infection. IgM anti-VCA was found in the 112 IM cases. High titers persisted at least 3 mo. as did heterophil antibodies. A IgG anti-VCA titer of .gtoreq. 1:256, an anti-EA titer of .gtoreq. 1:32, with a negative anti-EBNA titer, or a positive IgM anti-VCA with a negative anti-EBNA titer were reliable criteria of EBV primary infection in the 1st 2 wk. Seroepidemiology of EBV in Belgium was studied on 5178 sera of patients which were titrated for IgG antibodies against EBV-VCA and -EA. Results are presented according to age groups. Correlation between percentages of positive sera for anti-VCA and anti-EA antibodies allowed determination age groups at high risk of primary infection and indicated the possibility of reactivation in the elderly.

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Accession: 068632753

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PMID: 6297194

DOI: 10.1080/22953337.1982.11718879


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