+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

In vitro and in vivo studies on lidocaine formulated in an o/w cream and in a polyethylene glycol ointment



In vitro and in vivo studies on lidocaine formulated in an o/w cream and in a polyethylene glycol ointment



Acta Pharmaceutica Suecica 19(3): 229-240



Silicone membrane and isopropyl myristate (ISM) sink methods were used to study the release of lidocaine from an o/w [oil/water] cream and a polyethylene glycol (PEG) ointment base. For creams of different lidocaine concentrations, the rate of release was faster with the ISM method but slower for the PEG base. Diffusion coefficients independent of the initial concentation were calculated by using free unsolubilized lidocaine in the external aqueous phase as the saturation concentration in an equation designed for suspended drug. For the PEG base, independent values were obtained by assuming complete solubility of the drug. The local anesthetic effect of the formulations was measured by pin-pricking on guinea pig skin. Good correlations to both the in vitro methods were found. When comparing cream and ointment bases, the silicone membrane method appears to be more suitable. The topical efficacy of the 1% lidocaine cream is equal to that of the 5% ointment.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 068651775

Download citation: RISBibTeXText

PMID: 7113730


Related references

In vitro and in vivo studies on lidocaine formulated in an oil water cream and in a poly ethylene glycol ointment. Acta Pharmaceutica Suecica 19(3): 229-240, 1982

Corneal erosion by polyethylene glycol; examination of the aristamid eye ointment without polyethylene glycol, and toxic effect of pure polyethylene glycol for the eye. Klinische Monatsblatter für Augenheilkunde und für Augenarztliche Fortbildung 126(1): 76-77, 1955

Rheological Studies on Ointment Gels. 5. Studies on the Polyethylene Glycol Gel of the 3d Supplement of the Dab 6. Pharmaceutica Acta Helvetiae 39: 77-87, 1964

Electron microscopic studies of ointment bases and ointments. 1. Dispersity of polyethylene glycol (mol. wt. 1,000). Die Pharmazie 25(9): 539-541, 1970

In vitro and in vivo studies with human carrier erythrocytes loaded with polyethylene glycol-conjugated and native adenosine deaminase. British Journal of Haematology 109(3): 549-554, 2000

In-vitro and in-vivo evaluation of formulated lidocaine dental gels and ointments. Egyptian Journal of Pharmaceutical Sciences 38(4-6): 471-486, 1998

Studies on systemic absorption of tobramycin in polyethylene glycol ointment applied to wounds of burn patients. Burns 12(3): 153-160, 1986

In vitro studies of water activity and bacterial growth inhibition of sucrose-polyethylene glycol 400-hydrogen peroxide and xylose-polyethylene glycol 400-hydrogen peroxide pastes used to treat infected wounds. Antimicrobial Agents and ChemoTherapy 35(9): 1799-1803, 1991

In vitro and in vivo Evaluation of New Topical Anaesthetic Cream Formulated with Palm Oil Base. Current Drug Delivery 14(5): 690-695, 2017

In Vivo and In Vitro Feasibility Studies of Intraocular Use of Polyethylene Glycol-Based Synthetic Sealant to Close Retinal Breaks in Porcine and Rabbit Eyes. Investigative Ophthalmology and Visual Science 56(8): 4705-4711, 2015

Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. Journal of Rheumatology 29(9): 1942-1949, 2002

Comparison among conventional 4 L polyethylene glycol, split method of 4 L polyethylene glycol and combination of 2 L polyethylene glycol and sodium phosphate solution for colonoscopy preparation. Korean Journal of Gastroenterology 59(6): 414-422, 2012

Novel chitosan hydrogel formed by ethylene glycol chitosan, 1,6-diisocyanatohexan and polyethylene glycol-400 for tissue engineering scaffold: in vitro and in vivo evaluation. Journal of Materials Science. Materials in Medicine 25(8): 1903-1913, 2014

Influence of polyethylene glycol/polyethylene oxide on the release characteristics of sustained-release ethylcellulose mini-matrices produced by hot-melt extrusion: in vitro and in vivo evaluations. European Journal of Pharmaceutics and Biopharmaceutics 72(2): 463-470, 2009

An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine. Aaps Pharmsci 4(4): E40, 2002