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The distribution of soluble copper- and zinc-binding proteins in liver and kidney of chronic copper-poisoned goats



The distribution of soluble copper- and zinc-binding proteins in liver and kidney of chronic copper-poisoned goats



Acta Veterinaria Scandinavica 21(4): 578-586



The distribution of Cu and Zn among the soluble proteins in the liver and kidney from chronic Cu-poisoned goats was examined after gel filtration of the proteins. The Cu concentrations in the liver and kidney cortex from 5 experimentally Cu-poisoned goats were 550-810 .mu.g/g liver and 190-420 .mu.g/g kidney cortex (wet wt). The Cu-binding proteins from both the liver and kidney samples were separated into 2 different fractions with approximate MW of > 65,000 and 10,000, respectively. From the liver samples, varying amounts of Cu were eluted in a 4th fraction with MW < 2000. In the majority of kidney samples the dominating Cu-binding protein fraction was the high MW fraction. Absolute amounts of Cu recovered in the metallothionein-like protein fraction were nearly the same for all samples investigated. The distribution of Zn-binding proteins in both liver and kidney samples was nearly the same. The high MW fraction dominated, and no Zn was bound to metallothionein-like proteins.

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Accession: 068654540

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PMID: 7223583


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