Section 69
Chapter 68,679

Cross-reactivity between antibodies to thyroid microsomal antigens and myeloperoxidase

Haapala, A.M.; Hyöty, H.; Soppi, E.; Parkkonen, P.; Mustonen, J.; Pasternack, A.

Advances in Experimental Medicine and Biology 336: 81-85


ISSN/ISBN: 0065-2598
PMID: 8296680
Accession: 068678148

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Antibodies against thyroid microsomal antigen (thyroid peroxidase, TMA/TPO) and myeloperoxidase (MPO) were measured from 115 patients with vasculitic disorders and 144 patients with suspected thyroid disorders. Nineteen patients, three with vasculitis and 16 with thyroid disorders, were shown to have both TPO and MPO antibodies, suggesting cross-reactivity of these antibodies. Their cross-reactivity was further strengthened by studying the capacity of antibodies to tolerate dilution in enzyme immunoassay and reactivity with synthetic TPO/MPO peptides.

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