+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

When symptoms persist: clozapine augmentation strategies

When symptoms persist: clozapine augmentation strategies

Schizophrenia Bulletin 27(4): 615-628

Recent data and clinical experience confirm that, in spite of superior efficacy for treatment-refractory schizophrenia, a substantial proportion of patients receiving clozapine will continue to experience disabling symptoms. Optimizing clozapine monotherapy is the first step in the management of "clozapine nonresponders." Described here is a synthesis of the available literature on the range and efficacy of clozapine augmentation strategies that may be used when monotherapy fails. Treatment options include adjunctive antipsychotic medications, mood stabilizers, selective serotonin reuptake inhibitors, glycinergic agents, and electroconvulsive therapy. The evidence favoring one augmentation strategy over another is lacking; overall, adjunctive therapy is associated with only modest clinical improvement. Moreover, case series and open-labeled clinical trials dominate the extant literature, and there is a dearth of double-blind trials comparing these augmentation agents. Current systematic efforts to enhance the treatment of these patients with adjunctive therapies are worthy of being studied in carefully conducted clinical trials.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 068758496

Download citation: RISBibTeXText

PMID: 11824488

DOI: 10.1093/oxfordjournals.schbul.a006901

Related references

When symptoms persist: Clozapine augmentation strategies. Schizophrenia Bulletin 27(4): 615-628, 2001

Clozapine augmentation strategies - a systematic meta-review of available evidence. Treatment options for clozapine resistance. Journal of Psychopharmacology 33(4): 423-435, 2019

Clozapine resistance: augmentation strategies. European Neuropsychopharmacology 22(3): 165-182, 2012

Clozapine resistance--augmentation strategies. European Neuropsychopharmacology 23(4): 338, 2013

Clozapine resistan Augmentation strategies. 2011

Clozapine augmentation with aripiprazole for negative symptoms. Journal of Clinical Psychiatry 67(4): 675-676, 2006

Augmentation strategies in clozapine-resistant schizophrenia. Cns Drugs 19(10): 843-872, 2005

Aripiprazole augmentation in clozapine-associated obsessive-compulsive symptoms. Journal of Clinical Psychopharmacology 31(3): 375-376, 2011

Somatic augmentation strategies in clozapine resistance--what facts?. Clinical Neuropharmacology 29(1): 34-44, 2006

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia. Annals of General Psychiatry 12(1): 40, 2013

Augmentation strategies of clozapine with antipsychotics in the treatment of ultraresistant schizophrenia. Clinical Neuropharmacology 29(1): 28-33, 2006

Augmentation strategies for clozapine refractory schizophrenia: A systematic review and meta-analysis. Australian and New Zealand Journal of Psychiatry 52(8): 751-767, 2018

Augmentation strategies in patients with schizophrenia who show partial response to clozapine treatment. Turk Psikiyatri Dergisi 25(3): 201-211, 2014

Amisulpride augmentation for clozapine-refractory positive symptoms: additional benefit in reducing hypersialorrhea. Case Reports in Psychiatry 2015: 408179, 2015

Augmentation strategies in partial responder and/or treatment-resistant schizophrenia patients treated with clozapine. Expert Opinion on PharmacoTherapy 15(16): 2329-2345, 2014