Section 69
Chapter 68,773

Antimicrobial activity of broad-spectrum agents tested against Gram-negative bacilli resistant to ceftazidime: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001)

Jones, R.N.; Varnam, D.J.

Diagnostic Microbiology and Infectious Disease 44(4): 379-382


ISSN/ISBN: 0732-8893
PMID: 12543544
DOI: 10.1016/s0732-8893(02)00442-x
Accession: 068772640

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To assess the effect of ceftazidime resistance on the activity of other antimicrobial agents, 4,175 Gram-negative bacilli isolates, designated as ceftazidime-susceptible (3,759, 90%) or -resistant (416, 10%) were tested against a panel of nine agents. Cefepime was the most active of the agents tested, against both ceftazidime-susceptible and -resistant isolates, with a particularly low incidence (0.3%, 10/3152 isolates) of resistance among the Enterobacteriaceae. Tobramycin had the best activity against Pseudomonas aeruginosa and ticarcillin/clavulanate was the least active of the tested agents. This study confirms the need for constant monitoring of in vitro antimicrobial efficacy to direct empiric treatment regimens.

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