The first case of Anti-N-methyl-d-aspartate receptor encephalitis (Anti-NMDAR encephalitis) associated with ovarian mucinous cystadenoma: A case report

Cho, E.Hye.; Byun, J.Mi.; Park, H.Young.; Kang, M.Ri.; Jung, Y.Jung.; Jeong, C.Hoi.; Kim, Y.Nam.; Lee, K.Bok.; Sung, M.Su.; Jeong, D.Hoon.

Taiwanese Journal of Obstetrics and Gynecology 58(4): 557-559


ISSN/ISBN: 1028-4559
PMID: 31307751
DOI: 10.1016/j.tjog.2019.05.022
Accession: 069150690

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Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is a rare autoimmune and paraneoplastic encephalitis caused by the N-methyl-d-aspartate receptor antibody which is related to tumors, such as teratomas of the ovaries. To our knowledge, this is the first reported case of Anti-NMDAR encephalitis associated with ovarian mucinous cystadenoma. A 23-year-old woman with a flu-like illness, confused mental status, and behavioral changes presented to the hospital. A right-sided ovarian tumor was detected during the work-up and was suspected to be a teratoma that might have caused the encephalitis. A laparoscopic right salpingo-oophorectomy (RSO) was performed. Histopathological examination revealed a mucinous cystadenoma. She recovered gradually and had complete resolution of symptoms after surgical removal of the mucinous cystadenoma and immunotherapy. Even though anti-NMDAR encephalitis is caused by ovarian teratoma because it contains various types of tissues, ovarian tumors in anti-NMDAR encephalitis may not be limited to ovarian teratomas.