+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Porcine deltacoronavirus causes diarrhea in various ages of field-infected pigs in China



Porcine deltacoronavirus causes diarrhea in various ages of field-infected pigs in China



Bioscience Reports 39(9)



Porcine deltacoronavirus (PDCoV) is a novel coronavirus that causes acute diarrhea in suckling piglets. In Henan province of China, three swine farms broke out diarrhea in different ages of pigs during June of 2017, March of 2018 and January of 2019, respectively. PCR method, Taqman real-time RT-PCR method, sequencing, histopathology and immunohistochemistry (IHC) were conducted with the collected samples, and the results showed that PDCoV was detected among the suckling piglets, commercial fattening pigs and sows with diarrhea. PDCoV-infected suckling piglets were characterized with thin and transparent intestinal walls from colon to caecum, spot hemorrhage at mesentery and intestinal bleeding. PDCoV RNA was detected in multiple organs and tissues by Taqman real-time RT-PCR, which had high copies in ileum, inguinal lymph node, rectum and spleen. PDCoV antigen was detected in the basal layer of jejunum and ileum by IHC. In this research, we found that PDCoV could infect various ages of farmed pigs with watery diarrhea and anorexia in different seasons in a year.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 069309929

Download citation: RISBibTeXText

PMID: 31488617


Related references

Molecular evolution of porcine epidemic diarrhea virus and porcine deltacoronavirus strains in Central China. Research in Veterinary Science 120: 63-69, 2018

Isolation and characterization of porcine deltacoronavirus from pigs with diarrhea in the United States. Journal of Clinical Microbiology 53(5): 1537-1548, 2015

Isolation and phylogenetic analysis of porcine deltacoronavirus from pigs with diarrhoea in Hebei province, China. Transboundary and Emerging Diseases 65(3): 874-882, 2018

Detection and genetic characterization of porcine deltacoronavirus in Tibetan pigs surrounding the Qinghai-Tibet Plateau of China. Transboundary and Emerging Diseases 65(2): 363-369, 2018

Isolation of porcine epidemic diarrhea virus in porcine cell cultures and experimental infection of pigs of different ages. Veterinary Microbiology 72(3/4): 173-182, 2000

Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus. Veterinary Microbiology 186: 90-96, 2016

Nursery pig growth performance and tissue accretion modulation due to porcine epidemic diarrhea virus or porcine deltacoronavirus challenge. Journal of Animal Science 95(1): 173-181, 2017

Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus. Archives of Virology 162(8): 2357-2362, 2017

Evaluation of two singleplex reverse transcription-Insulated isothermal PCR tests and a duplex real-time RT-PCR test for the detection of porcine epidemic diarrhea virus and porcine deltacoronavirus. Journal of Virological Methods 234: 34-42, 2016

Porcine deltacoronavirus induces apoptosis in swine testicular and LLC porcine kidney cell lines in vitro but not in infected intestinal enterocytes in vivo. Veterinary Microbiology 182: 57-63, 2016

A Highly Pathogenic Strain of Porcine Deltacoronavirus Caused Watery Diarrhea in Newborn Piglets. Virologica Sinica 33(2): 131-141, 2018

Pathogenicity of 2 porcine deltacoronavirus strains in gnotobiotic pigs. Emerging Infectious Diseases 21(4): 650-654, 2015

Porcine Deltacoronavirus in Mainland China. Emerging Infectious Diseases 21(12): 2254-2255, 2015

Experimental infection of conventional nursing pigs and their dams with Porcine deltacoronavirus. Journal of Veterinary Diagnostic Investigation 28(5): 486-497, 2016

Porcine epidemic diarrhea: an emerging disease in Tibetan pigs in Tibet, China. Tropical Animal Health and Production 51(2): 491-494, 2019