+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro

Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro

Pathogens 8(3)

Porcine deltacoronavirus (PDCoV) is an emerging global swine virus that has a propensity for interspecies transmission. It was identified in Hong Kong in 2012. Given that neither specific antiviral drugs nor vaccines are available for newly emerging porcine deltacoronavirus, searching for effective antiviral drugs is a high priority. In this study, lithium chloride (LiCl) and diammonium glycyrrhizinate (DG), which are host-acting antivirals (HAAs), were tested against PDCoV. We found that LiCl and DG inhibited PDCoV replication in LLC-PK1 cells in a dose-dependent manner. The antiviral effects of LiCl and DG occurred at the early stage of PDCoV replication, and DG also inhibited virus attachment to the cells. Moreover, both drugs inhibited PDCoV-induced apoptosis in LLC-PK1 cells. This study suggests LiCl and DG as new drugs for the treatment of PDCoV infection.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 069325350

Download citation: RISBibTeXText

PMID: 31505777

Related references

Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus. Antiviral Research 85(2): 346-353, 2010

Antiviral effect of diammonium glycyrrhizinate on cell infection by porcine parvovirus. Current Microbiology 69(1): 82-87, 2014

Antiviral effect of lithium chloride on porcine epidemic diarrhea virus in vitro. Research in Veterinary Science 118: 288-294, 2018

Comparative analysis of the effect of glycyrrhizin diammonium and lithium chloride on infectious bronchitis virus infection in vitro. Avian Pathology 38(3): 215-221, 2009

Antiviral effect of lithium chloride on infection of cells by porcine parvovirus. Archives of Virology 160(4): 1015-1020, 2015

Novel antiviral effect of lithium chloride on mammalian orthoreoviruses in vitro. Microbial Pathogenesis 93: 152-157, 2016

Antiviral effect of lithium chloride on feline calicivirus in vitro. Archives of Virology 160(12): 2935-2943, 2015

A meta-analysis of diammonium glycyrrhizinate enteric-coated capsules versus diammonium glycyrrihizinate in patients with chronic viral hepatitis. Zhonghua Gan Zang Bing Za Zhi 22(6): 411-415, 2014

Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. Gastroenterology Research and Practice 2017: 8491742, 2017

The investigation on polyion complex micelles composed of diammonium glycyrrhizinate/poly(ethylene glycol)-glycidyltrimethylammonium chloride-grafted polyasparthydrazide. Aaps Pharmscitech 13(4): 1367-1376, 2012

Effect of phospholipid on absorption of diammonium glycyrrhizinate. Yao Xue Xue Bao 43(1): 71-75, 2008

Diammonium glycyrrhizinate attenuates Aβ(1-42) -induced neuroinflammation and regulates MAPK and NF-κB pathways in vitro and in vivo. Cns Neuroscience and Therapeutics 19(2): 117-124, 2013

Effect of diammonium glycyrrhizinate on entecavir pharmacokinetics in rats. Chinese Journal of Natural Medicines 11(3): 309-313, 2013

Dynamic observation of antifibrotic effect of diammonium glycyrrhizinate. Zhongguo Xinyao yu Linchuang Zazhi 22(6): 352-354, 2003

Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate: in vitro and in vivo characterization. Journal of Biomedical Materials Research. Part a 88(1): 140-148, 2009