+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection



Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection



Bmc Infectious Diseases 19(1): 870



Mortality is high among patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. We aimed to determine hospital mortality and the factors associated with it in a cohort of MERS-CoV patients. We reviewed hospital records of confirmed cases (detection of virus by polymerase chain reaction from respiratory tract samples) of MERS-CoV patients (n = 63) admitted to Buraidah Central Hospital in Al-Qassim, Saudi Arabia between 2014 and 2017. We abstracted data on demography, vital signs, associated conditions presented on admission, pre-existing chronic diseases, treatment, and vital status. Bi-variate comparisons and multiple logistic regressions were the choice of data analyses. The mean age was 60 years (SD = 18.2); most patients were male (74.6%) and Saudi citizens (81%). All but two patients were treated with Ribavirin plus Interferon. Hospital mortality was 25.4%. Patients who were admitted with septic shock and/or organ failure were significantly more likely to die than patients who were admitted with pneumonia and/or acute respiratory distress syndrome (OR = 47.9, 95% CI = 3.9, 585.5, p-value 0.002). Age, sex, and presence of chronic conditions were not significantly associated with mortality. Hospital mortality was 25%; septic shock/organ failure at admittance was a significant predictor of mortality.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 069443368

Download citation: RISBibTeXText

PMID: 31640578


Related references

Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity. Clinical Microbiology and Infection 22(10): 880-886, 2016

Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia. Bmc Infectious Diseases 16: 174, 2016

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics. European Review for Medical and Pharmacological Sciences 22(15): 4956-4961, 2018

The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study. Annals of Intensive Care 6(1): 101, 2016

Infection prevention and control guidelines for patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Saudi Medical Journal 35(8): 897-913, 2014

Clinical predictors of mortality of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: A cohort study. Travel Medicine and Infectious Disease 29: 48-50, 2019

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection. Journal of Infectious Diseases 213(10): 1557-1561, 2016

Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection. Annals of Internal Medicine 160(6): 389-397, 2014

Renal Complications and Their Prognosis in Korean Patients with Middle East Respiratory Syndrome-Coronavirus from the Central MERS-CoV Designated Hospital. Journal of Korean Medical Science 30(12): 1807-1814, 2015

Middle East respiratory syndrome coronavirus (MERS-CoV) infection. British Journal of Hospital Medicine 78(1): 23-26, 2017

Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings. Ajr. American Journal of Roentgenology 203(4): 782-787, 2014

First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities - May 2014. Mmwr. Morbidity and Mortality Weekly Report 63(19): 431-436, 2014

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America 110(41): 16598-16603, 2013

Clinical spectrum of the Middle East respiratory syndrome coronavirus (MERS-CoV). Journal of Infection and Public Health 10(2): 191-194, 2017

Middle East Respiratory Syndrome Coronavirus (Mers-CoV) Outbreak and National and Hospital Response in Korea. Prehospital and Disaster Medicine 32(S1): S4-S5, 2017