+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A Pediatric Case Report of Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis With Pericardial Effusion and Multiple Coronary Artery Aneurysms



A Pediatric Case Report of Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis With Pericardial Effusion and Multiple Coronary Artery Aneurysms



Journal of Pediatric Hematology/Oncology 2019



Pediatric coronary artery aneurysms (CAAs) are mainly detected in Kawasaki disease and in chronic active Epstein-Barr virus (EBV) infection sometimes, and cardiac complications are rare in viral-associated hemophagocytic lymphohistiocytosis (HLH) patients. Here, we report a pediatric case of EBV-associated HLH with pericardial effusion and multiple CAAs, whereas the patient did not fulfill the diagnostic criteria of Kawasaki disease or chronic active EBV. The case indicates that CAAs may occur in EBV-HLH. Specifically, in a patient with a long-term fever and a high EBV DNA copy number, the detection of cardiac complications may help signal the possible occurrence of HLH, and CAAs may affect the prognosis for high risk of cardiac events.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 069484378

Download citation: RISBibTeXText

PMID: 31688637


Related references

A child with Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis complicated by coronary artery lesion mimicking Kawasaki disease. Journal of Pediatric Hematology/Oncology 35(7): E317-E319, 2013

Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan. Pediatric Blood and Cancer 54(2): 299-306, 2010

Primary Epstein-Barr virus infection associated with Kikuchi's disease and hemophagocytic lymphohistiocytosis: a case report and review of the literature. Journal of Microbiology Immunology and Infection 43(3): 253-257, 2010

Dual Threat of Epstein-Barr Virus: an Autopsy Case Report of HIV-Positive Plasmablastic Lymphoma Complicating EBV-Associated Hemophagocytic Lymphohistiocytosis. Journal of Clinical Immunology 38(4): 478-483, 2018

Case Report: Hemophagocytic Lymphohistiocytosis Caused by Disseminated Histoplasmosis in a Venezuelan Patient with HIV and Epstein-Barr Virus Reactivation Who Traveled to Japan. American Journal of Tropical Medicine and Hygiene 100(2): 365-367, 2019

Diffuse large B-cell lymphoma in an adolescent female presenting with Epstein-Barr virus-driven hemophagocytic lymphohistiocytosis: a case report. Journal of Medical Case Reports 6: 141, 2012

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis: a retrospective study of 78 pediatric cases in mainland of China. Chinese Medical Journal 123(11): 1426-1430, 2010

Epstein-Barr virus-associated pericarditis and pericardial effusion: case report and diagnostic aspects. European Journal of Internal Medicine 16(7): 528-530, 2005

Clinically Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion Accompanied by Epstein-Barr Virus Hemophagocytic Lymphohistiocytosis: A Case Report and Review of the Literature. Journal of Pediatric Hematology/Oncology 39(2): E92-E96, 2017

Not another case of mono: Epstein-Barr virus (EBV) associate hemophagocytic lymphohistiocytosis (HLH). American Journal of Case Reports 14: 529-531, 2013

A case of hemophagocytic lymphohistiocytosis after the primary Epstein-Barr virus infection. Clinical and Applied Thrombosis/Hemostasis 13(3): 323-328, 2007

A case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications. Bmc Pediatrics 16(1): 172, 2016

A Case of Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis in Association With Pembrolizumab Therapy. American Journal of Clinical Pathology 149(Suppl_1): S71-S72, 2018

Treatment of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) in young adults: a report from the HLH study center. Medical and Pediatric Oncology 41(2): 103-109, 2003

Detection of Epstein-Barr virus DNA in cardiac and aortic tissues from chronic, active Epstein-Barr virus infection associated with Kawasaki disease-like coronary artery aneurysms. Journal Of Pediatrics. 123(1): 90-92, 1993