Section 70
Chapter 69,887

Use of Animal Models in Molecular Imaging

Alstrup, A.K.O.; Jensen, S.B.; Afzelius, P.; Neto, P.; Pedersen, M.

Contrast Media and Molecular Imaging 2020: 5168147


ISSN/ISBN: 1555-4317
PMID: 32140089
DOI: 10.1155/2020/5168147
Accession: 069886366

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Computational complexities encountered in craniospinal irradiation (CSI) have been widely investigated with different planning strategies. However, localization of the entire craniospinal axis (CSA) and evaluation of adaptive treatment plans have traditionally been ignored in Csi treatment. In this study, a new strategy for Csi with comprehensive Csa localization and adaptive plan evaluation has been demonstrated using cone beam Ct with extended longitudinal field-of-view (CBCTe LFOV). Multi-scan Cbct images were acquired with fixed longitudinal table translations (with 1 cm cone-beam overlap) and then fused into a single DICOM-set using the custom software coded in Mat Lab™. A novel approach for validation of CBCTe Lfov was demonstrated by combined geometry of Catphan-504 and Catphan-604 phantoms. To simulate actual treatment scenarios, at first, the end-to-end workflow of Csi with Vmat was investigated using an anthropomorphic phantom and then applied for two patients (based on random selection). The fused CBCTe Lfov images were in excellent agreement with planning Ct (p CT). The custom developed software effectively manages spatial misalignments arising out of the uncertainties in treatment/setup geometry. Although the structures mapped from p Ct to CBCTe Lfov showed minimal variations, a maximum spatial displacement of up to 1.2 cm (and the mean of 0.8 ± 0.3 cm) was recorded in phantom study. Adaptive plan evaluation of patient paradigms showed the likelihood of under-dosing the craniospinal target. Our protocol serves as a guide for precise localization of entire Csa and to ensure adequate dose to the large and complex targets. It can also be adapted for other complex treatment techniques such as total-marrow-irradiation and total-lymphoid-irradiation.

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