+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheep

Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheep

Nutrients 12(5)

ISSN/ISBN: 2072-6643

PMID: 32380648

DOI: 10.3390/nu12051312

Chorioamnionitis can lead to inflammation and injury of the liver and gut, thereby predisposing patients to adverse outcomes such as necrotizing enterocolitis (NEC). In addition, intestinal bile acids (BAs) accumulation is causally linked to NEC development. Plant sterols are a promising intervention to prevent NEC development, considering their anti-inflammatory properties in the liver. Therefore, we investigated whether an intra-amniotic (IA) Ureaplasma parvum (UP) infection affected the liver and enterohepatic circulation (EHC) and evaluated whether an IA administered plant sterol mixture dissolved in β-cyclodextrin exerted prophylactic effects. An ovine chorioamnionitis model was used in which liver inflammation and the EHC were assessed following IA UP exposure in the presence or absence of IA prophylactic plant sterols (a mixture of β-sitosterol and campesterol dissolved in β-cyclodextrin (carrier)) or carrier alone. IA UP exposure caused an inflammatory reaction in the liver, histologically seen as clustered and conflated hepatic erythropoiesis in the parenchyma, which was partially prevented by IA administration of sterol + β-cyclodextrin, or β-cyclodextrin alone. In addition, IA administration of β-cyclodextrin prior to UP caused changes in the expression of several hepatic BAs transporters, without causing alterations in other aspects of the EHC. Thereby, the addition of plant sterols to the carrier β-cyclodextrin did not have additional effects.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 070099086

Download citation: RISBibTeXText

Related references

Inflammation in fetal sheep from intra-amniotic injection of Ureaplasma parvum. American Journal of Physiology. Lung Cellular and Molecular Physiology 299(6): L852-L860, 2010

Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses. Frontiers in Immunology 11: 189, 2020

Intra-uterine experimental infection by Ureaplasma diversum induces TNF-α mediated womb inflammation in mice. Anais da Academia Brasileira de Ciencias 88(Suppl): 643-652, 2016

Uterine activity following intra venous administration of oxytocin to the fetal sheep. Nature (London) 243(5408): 471-472, 1973

The effects of maternal oxygen inhalation on uterine and fetal circulation in pregnancies with intra uterine growth retardation and its prognostic significance. Zeitschrift fuer Geburtshilfe und Perinatologie 196(2): 67-73, 1992

Effect of N-acetylcysteine on lipopolysaccharide-induced intra-uterine fetal death and intra-uterine growth retardation in mice. Toxicological Sciences: An Official Journal of the Society of Toxicology 88(2): 525-533, 2005

Ascorbic acid protects against lipopolysaccharide-induced intra-uterine fetal death and intra-uterine growth retardation in mice. Toxicology 217(1): 39-45, 2006

Intra-uterine extra-amniotic prostaglandin F2-alpha in the management of patients with intra-uterine fetal death. South African Medical Journal 53(21): 848-852, 1978

The placenta in intrauterine fetal deprivation. I. The biochemical profile of placentas from cases of intrauterine growth-retarded gestation of toxemic and non-toxemic origin. Acta Obstetricia et Gynecologica Scandinavica 60(2): 141-147, 1981

Intra-amniotic Ureaplasma parvum-Induced Maternal and Fetal Inflammation and Immune Responses in Rhesus Macaques. Journal of Infectious Diseases 214(10): 1597-1604, 2016

Intra-uterine asphyxia. An experimental study in rabbits and sheep with special reference to uterine blood flow and fetal cerebral reactions. Acta Obstetricia et Gynecologica Scandinavica. Supplement 1974(35): 1-40, 1974

P1227 : Intra-hepatic Cholestasis of Pregnancy (Icp): Prevention of recurrence of Icp and intra uterine fetal death by pre-pruritus administration of ursodeoxycholic acid. Journal of Hepatology 62: S816-S817, 2015

Intra-uterine Transfusions to the Rhesus-Immunized Fetus in the Department of Obstetrics, National Hospital, Oslo 19681979. The Fetal Prognosis by Intra-uterine Transfusions in Relation to Amniotic Fluid Blood Pigment Index. Obstetric and Gynecologic Survey 39(6): 373-374, 1984

Intra-uterine transfusions to the Rhesus-immunized fetus in the Department of Obstetrics, National Hospital, Oslo 1968-1979. The fetal prognosis by intra-uterine transfusions in relation to amniotic fluid blood pigment index. Acta Obstetricia et Gynecologica Scandinavica 62(4): 349-352, 1983

Dislocated intra uterine device and intra uterine ectopic pregnancy with uterine rupture. Obstetrics and Gynecology 47(3): 365-396, 1976