Metastatic growth of human tumour xenografts in thymectomised irradiated mice reconstituted with syngeneic bone marrow cells

Franks, C.R.; Boulger, L.R.; Garrett, A.J.; Bishop, D.; Reeson, D.; Perkins, F.T.

European Journal of Cancer (1965) 11(9): 619-622

1965


ISSN/ISBN: 0959-8049
DOI: 10.1016/0014-2964(75)90095-x
Accession: 070195301

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Abstract
Human tumour xenografts were grown by s. c. implantation in thymectomised irradiated mice reconstituted with syngeneic bone marrow cells. Sixty-three tumour specimens were implanted into 462 mice, and tumour survivals of 1 to 20 weeks were recorded. At autopsy, a comprehensive macroscopic and microscopic examination was made. Eighteen cases of metastasis were observed from 5 different tumour types.