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Role of Amlavetasa (Garcinia pedunculata Roxb. ex Buch.-Ham.), an Ayurvedic drug in E-beta Thalassaemia : A case study

Role of Amlavetasa (Garcinia pedunculata Roxb. ex Buch.-Ham.), an Ayurvedic drug in E-beta Thalassaemia : A case study

Indian Journal of Traditional Knowledge 17(3): 598-601

ISSN/ISBN: 0972-5938

Thalassaemia has been recognized by the World Health Organization as an important inherited disorder which has an impact mainly on the populations of low income countries. The prevalence of variant haemoglobins varies considerably with geographic location and racial groups. Four hemoglobin variants, Hb S, Hb C, Hb E, and Hb D each affects millions worldwide and they represent a major public health problem in many areas of the world including South East Asia. However, in India, haemoglobin E-beta thalassemia is prevalent in Bengal and the North-eastern region, but relatively rare in the rest of the country. Genotype is responsible for almost one-half of all severe beta thalassemia worldwide characterized by marked clinical variability from asymptomatic anemia to a life-threatening disorder requiring regular blood transfusions from infancy life, iron chelation and management of secondary complications of iron overload. Ayurveda texts do not describe any disease similar to thalassemia. But considering the pathophysiology of disease in Ayurveda, it may be understood as a Beejadoshajanya Panda. The following case study focuses on effect of Amlavetas as a new adjuvent treatment on an 8-year-old girl having Hb E-beta-thalassemia with several episodes of blood transfusions and increased serum ferritin level (2514 ng/mL) whose serum iron was marked down to significant level in due course of treatment. An effort was made with the hypothesis that Amlavetasa acts as an iron chelator in the management of beta thalassemia (Hemoglobin E Disease) and improves the quality of life by increasing the gap of blood transfusion. Assessment was done on subjective and objective parameters after 6 months of treatment with follow up of two months.

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Accession: 070869893

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