Efficacy of oral supplementation of whey protein in patients with contact dermatitis: A pilot randomized double-blind placebo-controlled clinical trial
Alyasin, S.; Nabavizadeh, S.Hesamedin.; Esmaeilzadeh, H.; Heydari, S.Taghi.; Mosavat, S.Hamdollah.; Parvizi, M.Mahdi.; Hashemi, S.Mohammad.; Hashempur, M.Hashem.
Dermatologic Therapy 2020: E14260
2020
ISSN/ISBN: 1529-8019 PMID: 32876987 DOI: 10.1111/dth.14260
Accession: 071049481
Whey protein is a popular dietary product that has numerous health benefits such as immune modulation. In this study, we assessed efficacy of whey protein in management of patients with contact dermatitis (CD) through a double blind, randomized controlled clinical trial in Emam Reza clinic, Shiraz, Iran. Twenty-five patients in each group were randomly assigned to receive whey protein or placebo powder, 30 g in 200 mL warm water at fasting time for 4 weeks. Outcome measures were Dermatology Life Quality Index (DLQI) questionnaire and the Eczema Area and Severity Index (EASI) score. Furthermore, subjective total improvement (assessed by visual analogue scale) was set as the other primary outcome measure. A significant decrease was observed in the scores of EASI, DLQI, and subjective total improvement in the drug group after the intervention compared with the baseline. However, no changes were seen in the placebo group. Moreover, there was a significant reduction in the scores of EASI (P= .002) and subjective total improvement scores (P= .039) over the study period in the drug group compared with the placebo group. According to the results of this study, it seems that oral supplementation of whey protein could improve the symptoms of CD compared with placebo.