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Section 72

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References:

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Li, Q.; Li, J.; Cai, Y.; Zou, Y.; Chen, B.; Zou, F.; Mo, J.; Han, T.; Guo, W.; Huang, W.; Qiu, Q.; Qian, H. 2020: Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors. Bioorganic and Medicinal Chemistry 28(15): 115601
Zhou, S.; Huang, G. 2020: Design, synthesis and biological evaluation of novel 7H-benzo [c] [1, 3] dioxolo [4, 5-f] chromen-7-one derivatives with potential anti-tumor activity. Bioorganic Chemistry 105: 104381
Lei, Y.; Zhang, B.; Zhang, Y.; Dai, X.; Duan, Y.; Mao, Q.; Gao, J.; Yang, Y.; Bao, Z.; Fu, X.; Ping, K.; Yan, C.; Mou, Y.; Wang, S. 2021: Design, synthesis and biological evaluation of novel FXIa inhibitors with 2-phenyl-1H-imidazole-5-carboxamide moiety as P1 fragment. European Journal of Medicinal Chemistry 220: 113437
Yao, D.; Li, C.; Jiang, J.; Huang, J.; Wang, J.; He, Z.; Zhang, J. 2020: Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer. European Journal of Medicinal Chemistry 205: 112648
Nan, X.; Zhang, J.; Li, H.-J.; Wu, R.; Fang, S.-B.; Zhang, Z.-Z.; Wu, Y.-C. 2020: Design, synthesis and biological evaluation of novel N-sulfonylamidine-based derivatives as c-Met inhibitors via Cu-catalyzed three-component reaction. European Journal of Medicinal Chemistry 200: 112470
Ren, Y.; Ruan, Y.; Cheng, B.; Li, L.; Liu, J.; Fang, Y.; Chen, J. 2021: Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities. Bioorganic and Medicinal Chemistry 46: 116376
Zuo, J.; Wang, S.-M.; Jiang, X.; Cao, M.; Zhang, Z.; Shi, T.; Qin, H.-L.; Tang, W. 2020: Design, synthesis and biological evaluation of novel arylpropionic esters for the treatment of acute kidney injury. Bioorganic Chemistry 105: 104455
Hawash, M.; Jaradat, N.; Hameedi, S.; Mousa, A. 2020: Design, synthesis and biological evaluation of novel benzodioxole derivatives as COX inhibitors and cytotoxic agents. Bmc Chemistry 14(1): 54
Zhang, X.; Huang, H.; Zhang, Z.; Yan, J.; Wu, T.; Yin, W.; Sun, Y.; Wang, X.; Gu, Y.; Zhao, D.; Cheng, M. 2021: Design, synthesis and biological evaluation of novel benzofuran derivatives as potent LSD1 inhibitors. European Journal of Medicinal Chemistry 220: 113501
Chu, Z.; Xu, Q.; Zhu, Q.; Ma, X.; Mo, J.; Lin, G.; Zhao, Y.; Gu, Y.; Bian, L.; Shao, L.; Guo, J.; Ye, W.; Li, J.; He, G.; Xu, Y. 2021: Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis. European Journal of Medicinal Chemistry 213: 113171
Burmaoglu, S.; Gobek, A.; Aydin, B.O.; Yurtoglu, E.; Aydin, B.N.; Ozkat, G.Y.; Hepokur, C.; Ozek, N.S.; Aysin, F.; Altundas, R.; Algul, O. 2021: Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents. Bioorganic Chemistry 111: 104882
Dong, Y.; Hu, H.; Sun, Y.; Qin, M.; Gong, P.; Hou, Y.; Zhao, Y. 2020: Design, synthesis and biological evaluation of novel c-Met/HDAC dual inhibitors. Bioorganic and Medicinal Chemistry Letters 30(23): 127610
Hao, S.; Cheng, X.; Wang, X.; An, R.; Xu, H.; Guo, M.; Li, C.; Wang, Y.; Hou, Z.; Guo, C. 2020: Design, synthesis and biological evaluation of novel carbohydrate-based sulfonamide derivatives as antitumor agents. Bioorganic Chemistry 104: 104237
Huo, P.-C.; Hu, Q.; Shu, S.; Zhou, Q.-H.; He, R.-J.; Hou, J.; Guan, X.-Q.; Tu, D.-Z.; Hou, X.-D.; Liu, P.; Zhang, N.; Liu, Z.-G.; Ge, G.-B. 2021: Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors. Bioorganic and Medicinal Chemistry 29: 115853
Wei, Q.; Mei, L.; Chen, P.; Yuan, X.; Zhang, H.; Zhou, J. 2020: Design, synthesis and biological evaluation of novel chroman derivatives as non-selective acetyl-CoA carboxylase inhibitors. Bioorganic Chemistry 101: 103943
Nerella, A.; Jeripothula, M. 2021: Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease. Bioorganic and Medicinal Chemistry Letters 49: 128212
Ji, Q.; Li, B.; Chu, Y.; Wu, H.; Du, C.; Xu, Y.; Shen, Y.; Deng, J. 2021: Design, synthesis and biological evaluation of novel diazaspirodecanone derivatives containing piperidine-4-carboxamide as chitin synthase inhibitors and antifungal agents. Bioorganic Chemistry 114: 105108
Jójárt, R.; Laczkó-Rigó, R.ék.; Klement, M.át.é; Kőhl, G.; Kecskeméti, G.áb.; Özvegy-Laczka, C.; Mernyák, E.éb. 2021: Design, synthesis and biological evaluation of novel estrone phosphonates as high affinity organic anion-transporting polypeptide 2B1 (OATP2B1) inhibitors. Bioorganic Chemistry 112: 104914
Wu, Z.; Xia, M.-B.; Bertsetseg, D.; Wang, Y.-H.; Bao, X.-L.; Zhu, W.-B.; Tao-Xu; Chen, P.-R.; Tang, H.-S.; Yan, Y.-J.; Chen, Z.-L. 2020: Design, synthesis and biological evaluation of novel fluoro-substituted benzimidazole derivatives with anti-hypertension activities. Bioorganic Chemistry 101: 104042
Al-Oudat, B.A.; Jaradat, H.'a.M.; Al-Balas, Q.A.; Al-Shar'i, N.A.; Bryant-Friedrich, A.; Bedi, M.F. 2020: Design, synthesis and biological evaluation of novel glyoxalase i inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents. Bioorganic and Medicinal Chemistry 28(16): 115608
Yang, X.; Hou, Z.; Wang, D.; Mou, Y.; Guo, C. 2020: Design, synthesis and biological evaluation of novel heptamethine cyanine dye-erlotinib conjugates as antitumor agents. Bioorganic and Medicinal Chemistry Letters 30(23): 127557
Zhai, S.; Zhang, H.; Chen, R.; Wu, J.; Ai, D.; Tao, S.; Cai, Y.; Zhang, J.-Q.; Wang, L. 2021: Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma. European Journal of Medicinal Chemistry 225: 113824
Rahimzadeh Oskuei, S.; Mirzaei, S.; Reza Jafari-Nik, M.; Hadizadeh, F.; Eisvand, F.; Mosaffa, F.; Ghodsi, R. 2021: Design, synthesis and biological evaluation of novel imidazole-chalcone derivatives as potential anticancer agents and tubulin polymerization inhibitors. Bioorganic Chemistry 112: 104904
Abolhasani, H.; Zarghi, A.; Komeili Movahhed, T.; Abolhasani, A.; Daraei, B.; Dastmalchi, S. 2021: Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents. Bioorganic and Medicinal Chemistry 32: 115960
Shen, H.; Ge, Y.; Wang, J.; Li, H.; Xu, Y.; Zhu, Q. 2021: Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors. Bioorganic and Medicinal Chemistry Letters 47: 128169
Uysal, S.; Soyer, Z.; Saylam, M.; Tarikogullari, A.H.; Yilmaz, S.; Kirmizibayrak, P.B. 2021: Design, synthesis and biological evaluation of novel naphthoquinone-4-aminobenzensulfonamide/carboxamide derivatives as proteasome inhibitors. European Journal of Medicinal Chemistry 209: 112890
Feng, Y.; Lu, Y.; Li, J.; Zhang, H.; Li, Z.; Feng, H.; Deng, X.; Liu, D.; Shi, T.; Jiang, W.; He, Y.; Zhang, J.; Wang, Z. 2022: Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo. European Journal of Medicinal Chemistry 227: 113888
Zhang, L.; Wu, Y.; Yang, G.; Gan, H.; Sang, D.; Zhou, J.; Su, L.; Wang, R.; Ma, L. 2020: Design, synthesis and biological evaluation of novel osthole-based derivatives as potential neuroprotective agents. Bioorganic and Medicinal Chemistry Letters 30(24): 127633
Huang, S.-Y.; Wang, X.; Shen, D.-Y.; Chen, F.; Zhang, G.-Y.; Zhang, Z.; Li, K.; Jin, Z.; Du, D.; Tang, Y.-Z. 2021: Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome. Bioorganic and Medicinal Chemistry 38: 116138
Zhang, G.-Y.; Zhang, Z.; Li, K.; Liu, J.; Li, B.; Jin, Z.; Liu, Y.-H.; Tang, Y.-Z. 2020: Design, synthesis and biological evaluation of novel pleuromutilin derivatives containing piperazine and 1,2,3-triazole linker. Bioorganic Chemistry 105: 104398
Li, N.; Ou, J.; Bao, N.; Chen, C.; Shi, Z.; Chen, L.; Sun, J. 2020: Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition. Bioorganic Chemistry 104: 104208
Feng, K.-R.; Wang, F.; Shi, X.-W.; Tan, Y.-X.; Zhao, J.-Y.; Zhang, J.-W.; Li, Q.-H.; Lin, G.-Q.; Gao, D.; Tian, P. 2020: Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. European Journal of Medicinal Chemistry 201: 112428
Li, Z.; Xu, L.; Zhu, L.; Zhao, Y.; Hu, T.; Yin, B.; Liu, Y.; Hou, Y. 2020: Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors. Bioorganic and Medicinal Chemistry Letters 30(16): 127329
Zhang, B.; Huang, Y.; Zhang, S.-R.; Huang, M.-X.; Zhang, C.; Luo, H.-B. 2021: Design, synthesis and biological evaluation of novel pyrazolopyrimidone derivatives as potent PDE1 inhibitors. Bioorganic Chemistry 114: 105104
Si, D.; Luo, H.; Zhang, X.; Yang, K.; Wen, H.; Li, W.; Liu, J. 2021: Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors. Bioorganic Chemistry 115: 105268
Golani, L.K.; Islam, F.; O'Connor, C.; Dekhne, A.S.; Hou, Z.; Matherly, L.H.; Gangjee, A. 2020: Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. Bioorganic and Medicinal Chemistry 28(12): 115544
Liu, J.; Liu, Y.; Yu, H.; Zhang, Y.; Hsu, A.C.-Y.; Zhang, M.; Gou, Y.; Sun, W.; Wang, F.; Li, P.; Liu, J. 2021: Design, synthesis and biological evaluation of novel pyxinol derivatives with anti-heart failure activity. Biomedicine and PharmacoTherapy 133: 111050
Reddy, G.L.; Sarma, R.; Liu, S.; Huang, W.; Lei, J.; Fu, J.; Hu, W. 2021: Design, synthesis and biological evaluation of novel scaffold benzo[4,5]imidazo [1,2-a]pyrazin-1-amine: Towards adenosine A2A receptor (A2A AR) antagonist. European Journal of Medicinal Chemistry 210: 113040
Yao, D.; Huang, J.; Wang, J.; He, Z.; Zhang, J. 2020: Design, synthesis and biological evaluation of novel tetrahydrothieno [2,3-c]pyridine substitued benzoyl thiourea derivatives as PAK1 inhibitors in triple negative breast cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1524-1538
Du, L.; Wang, X.; Cui, G.; Xu, B. 2021: Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors. Bioorganic and Medicinal Chemistry 29: 115878
Dang, X.; Lei, S.; Luo, S.; Hu, Y.; Wang, J.; Zhang, D.; Lu, D.; Jiang, F.; Fu, L. 2021: Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells. Bioorganic Chemistry 114: 105015
Wang, G.; Liu, W.; Fan, M.; He, M.; Li, Y.; Peng, Z. 2021: Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 1694-1702
Wang, A.; Wang, Y.; Meng, X.; Yang, Y. 2021: Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer. Bioorganic and Medicinal Chemistry 31: 115953
He, Z.-X.; Huo, J.-L.; Gong, Y.-P.; An, Q.; Zhang, X.; Qiao, H.; Yang, F.-F.; Zhang, X.-H.; Jiao, L.-M.; Liu, H.-M.; Ma, L.-Y.; Zhao, W. 2021: Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells. European Journal of Medicinal Chemistry 210: 112970
Liu, P.; Fan, S.; Wang, B.; Cao, R.; Wang, X.; Li, S.; Lu, Y.; Zhong, W. 2020: Design, synthesis and biological evaluation of novel triaryldimethylaminobutan-2-ol derivatives against Mycobacterium tuberculosis. Bioorganic Chemistry 102: 104054
Li, B.; Zhang, Z.; Zhang, J.-F.; Liu, J.; Zuo, X.-Y.; Chen, F.; Zhang, G.-Y.; Fang, H.-Q.; Jin, Z.; Tang, Y.-Z. 2021: Design, synthesis and biological evaluation of pleuromutilin-Schiff base hybrids as potent anti-MRSA agents in vitro and in vivo. European Journal of Medicinal Chemistry 223: 113624
Su, Z.; Yang, T.; Wang, J.; Lai, M.; Tong, L.; Wumaier, G.; Chen, Z.; Li, S.; Li, H.; Xie, H.; Zhao, Z. 2020: Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation. Bioorganic and Medicinal Chemistry Letters 30(16): 127327
Guo, J.; Mi, Z.; Jiang, X.; Zhang, C.; Guo, Z.; Li, L.; Gu, J.; Zhou, T.; Bai, R.; Xie, Y. 2021: Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects. Bioorganic Chemistry 108: 104564
Yu, B.; Zhao, B.; Hao, Z.; Chen, L.; Cao, L.; Guo, X.; Zhang, N.; Yang, D.; Tang, L.; Fan, Z. 2021: Design, synthesis and biological evaluation of pyrazole-aromatic containing carboxamides as potent SDH inhibitors. European Journal of Medicinal Chemistry 214: 113230
Wu, X.; Dai, M.; Cui, R.; Wang, Y.; Li, C.; Peng, X.; Zhao, J.; Wang, B.; Dai, Y.; Feng, D.; Yang, T.; Jiang, H.; Geng, M.; Ai, J.; Zheng, M.; Liu, H. 2021: Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors. Acta Pharmaceutica Sinica. B 11(3): 781-794
Gilles, P.; Kashyap, R.S.; Freitas, M.J.ão.; Ceusters, S.; Van Asch, K.; Janssens, A.; De Jonghe, S.; Persoons, L.; Cobbaut, M.; Daelemans, D.; Van Lint, J.; Voet, A.R.D.; De Borggraeve, W.M. 2020: Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors. European Journal of Medicinal Chemistry 205: 112638
Jin, C.; Yi, C.; Zhong, W.; Xue, Y.; Chen, K.; Deng, K.; Wang, Z.; Wang, T. 2021: Design, synthesis and biological evaluation of pyridinylmethylenepiperidine derivatives as potent 5-HT1F receptor agonists for migraine therapy. European Journal of Medicinal Chemistry 225: 113782
Pan, C.; Nie, W.; Wang, J.; Du, J.; Pan, Z.; Gao, J.; Lu, Y.; Che, J.; Zhu, H.; Dai, H.; Chen, B.; He, Q.; Dong, X. 2021: Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors. European Journal of Medicinal Chemistry 225: 113794
Xie, S.-S.; Liu, J.; Tang, C.; Pang, C.; Li, Q.; Qin, Y.; Nong, X.; Zhang, Z.; Guo, J.; Cheng, M.; Tang, W.; Liang, N.; Jiang, N. 2020: Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease. European Journal of Medicinal Chemistry 202: 112475
Xie, H.; Lin, X.; Zhang, Y.; Tan, F.; Chi, B.; Peng, Z.; Dong, W.; An, D. 2020: Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors. Bioorganic and Medicinal Chemistry Letters 30(21): 127459
Granchi, C.; Bononi, G.; Ferrisi, R.; Gori, E.; Mantini, G.; Glasmacher, S.; Poli, G.; Palazzolo, S.; Caligiuri, I.; Rizzolio, F.; Canzonieri, V.; Perin, T.; Gertsch, J.ür.; Sodi, A.; Giovannetti, E.; Macchia, M.; Minutolo, F.; Tuccinardi, T.; Chicca, A. 2021: Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. European Journal of Medicinal Chemistry 209: 112857
Xu, Q.; Mou, Y.; Wang, S.; Gao, X.; Zhang, Y.; Wang, Z.; Xu, X.; Han, Y.; Jia, W.; Zhang, M.; Zhao, L.; Liu, D. 2021: Design, synthesis and biological evaluation of selective histone deacetylase 6 (HDAC6) inhibitors bearing benzoindazole or pyrazoloindazole scaffold as surface recognition motif. Bioorganic Chemistry 111: 104910
Kumar Pasala, V.; Gudipudi, G.; Sankeshi, V.; Basude, M.; Gundla, R.; Singh Jadav, S.; Srinivas, B.; Yadaiah Goud, E.; Nareshkumar, D. 2021: Design, synthesis and biological evaluation of selective hybrid coumarin-thiazolidinedione aldose reductase-Ii inhibitors as potential antidiabetics. Bioorganic Chemistry 114: 104970
Tok, F.; İrem Abas, B.çi.; Çevik, Öz.; Koçyiğit-Kaymakçıoğlu, B. 2020: Design, synthesis and biological evaluation of some new 2-Pyrazoline derivatives as potential anticancer agents. Bioorganic Chemistry 102: 104063
Luo, D.; Zhang, Y.; Yang, S.; Tian, X.; Lv, Y.; Guo, Z.; Liu, X.; Han, G.; Liu, S.; Wang, W.; Cui, S.; Qu, X.; Wan, S. 2021: Design, synthesis and biological evaluation of sphingosine-1-phosphate receptor 2 antagonists as potent 5-FU-resistance reversal agents for the treatment of colorectal cancer. European Journal of Medicinal Chemistry 225: 113775
Zhang, B.; Liu, Z.; Xia, S.; Liu, Q.; Gou, S. 2021: Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors. European Journal of Medicinal Chemistry 216: 113300
Huang, H.; Yao, Y.; Hou, G.; Zhao, C.; Qin, J.; Zhang, Y.; Duan, Y.; Song, C.; Chang, J. 2021: Design, synthesis and biological evaluation of tanshinone IIA-based analogues: Potent inhibitors of microtubule formation and angiogenesis. European Journal of Medicinal Chemistry 224: 113708
Han, Y.; Tian, Y.; Wang, R.; Fu, S.; Jiang, J.; Dong, J.; Qin, M.; Hou, Y.; Zhao, Y. 2020: Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition. Bioorganic Chemistry 104: 104197
Wang, Y.; Mi, T.; Li, Y.; Kan, W.; Xu, G.; Li, J.; Zhou, Y.; Li, J.; Jiang, X. 2021: Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity. European Journal of Medicinal Chemistry 209: 112912
Yang, Y.; Wang, K.; Wu, B.; Yang, Y.; Lai, F.; Chen, X.; Xiao, Z. 2020: Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors. Bioorganic and Medicinal Chemistry Letters 30(21): 127508
Jain, A.; Piplani, P. 2020: Design, synthesis and biological evaluation of triazole-oxadiazole conjugates for the management of cognitive dysfunction. Bioorganic Chemistry 103: 104151
Fu, D.; Yuan, Y.; Qin, F.; Xu, Y.; Cui, X.; Li, G.; Yao, S.; Deng, Y.; Tang, Z. 2021: Design, synthesis and biological evaluation of tyrosinase-targeting PROTACs. European Journal of Medicinal Chemistry 226: 113850
Zhu, H.; Sun, H.; Liu, Y.; Duan, Y.; Liu, J.; Yang, X.; Li, W.; Qin, S.; Xu, S.; Zhu, Z.; Xu, J. 2020: Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. European Journal of Medicinal Chemistry 207: 112716
Talmon, M.; Chaudhari, R.D.; Suryavanshi, H.; Chowdhury, N.; Quaregna, M.; Pin, A.; Bagchi, A.; Biswas, G.; Fresu, L.G. 2020: Design, synthesis and biological evaluation of vortioxetine derivatives as new COX-1/2 inhibitors in human monocytes. Bioorganic and Medicinal Chemistry 28(23): 115760
Keleş, T.; Barut, B.; Özel, A.; Biyiklioglu, Z. 2021: Design, synthesis and biological evaluation of water soluble and non-aggregated silicon phthalocyanines, naphthalocyanines against A549, SNU-398, SK-MEL128, DU-145, BT-20 and HFC cell lines as potential anticancer agents. Bioorganic Chemistry 107: 104637
Takahashi, M.; Lee, Y.J.; Kanayama, T.; Kondo, Y.; Nishio, K.; Mukai, K.; Haba, M.; Hosokawa, M. 2020: Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 152: 105455
Al-Hilal, T.A.; Hossain, M.A.; Alobaida, A.; Alam, F.; Keshavarz, A.; Nozik-Grayck, E.; Stenmark, K.R.; German, N.A.; Ahsan, F. 2021: Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects. Journal of Controlled Release: Official Journal of the Controlled Release Society 334: 237-247
Ran, K.; Zeng, J.; Wan, G.; He, X.; Feng, Z.; Xiang, W.; Wei, W.; Hu, X.; Wang, N.; Liu, Z.; Yu, L. 2021: Design, synthesis and biological evaluations of a series of Pyrido[1,2-a]pyrimidinone derivatives as novel selective FGFR inhibitors. European Journal of Medicinal Chemistry 220: 113499
Zhong, Y.; Liu, J.; Cheng, X.; Zhang, H.; Zhang, C.; Xia, Z.; Wu, Z.; Zhang, L.; Zheng, Y.; Gao, Z.; Jiang, Z.; Wang, Z.; Huang, D.; Lu, Y.; Jiang, F. 2021: Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors. Bioorganic Chemistry 109: 104736
Popov, A.; Klimovich, A.; Styshova, O.; Moskovkina, T.; Shchekotikhin, A.; Grammatikova, N.; Dezhenkova, L.; Kaluzhny, D.; Deriabin, P.; Gerasimenko, A.; Udovenko, A.; Stonik, V. 2020: Design, synthesis and biomedical evaluation of mostotrin, a new water soluble tryptanthrin derivative. International Journal of Molecular Medicine 46(4): 1335-1346
Liu, M.; Whitfield, E.A.; Fothergill, L.J.; Furness, J.B.; Wade, J.D.; Furness, S.G.B.; Hossain, M.A. 2020: Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin. Biochemical and Biophysical Research Communications 533(3): 559-564
Li, H.; Pan, Y.; Li, C.; Yang, Z.; Rao, J.; Chen, B. 2022: Design, synthesis and characterization of lysozyme-gentisic acid dual-functional conjugates with antibacterial/antioxidant activities. Food Chemistry 370: 131032
Pandey, K.P.; Khan, Z.A.; Golani, L.K.; Mondal, P.; Mian, Y.; Rashid, F.; Tiruveedhula, V.V.N.P.B.; Knutson, D.E.; Sharmin, D.; Ahmed, T.; Rezvanian, S.; Zahn, N.M.; Arnold, L.A.; Witkin, J.M.; Cook, J.M. 2020: Design, synthesis and characterization of novel gamma‑aminobutyric acid type a receptor ligands. Arkivoc: Free Online Journal of Organic Chemistry 2020(Part 7): 242-256
Kirkeby, E.K.; Roberts, A.G. 2020: Design, synthesis and characterization of structurally dynamic cyclic N,S-acetals. Chemical Communications 56(64): 9118-9121
Dheer, D.; Behera, C.; Singh, D.; Abdullaha, M.; Chashoo, G.; Bharate, S.B.; Gupta, P.N.; Shankar, R. 2020: Design, synthesis and comparative analysis of triphenyl-1,2,3-triazoles as anti-proliferative agents. European Journal of Medicinal Chemistry 207: 112813
Khidre, R.E.; Radini, I.Ali.M. 2021: Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents. Scientific Reports 11(1): 7846
Raj Dwivedi, G.; Khwaja, S.; Singh Negi, A.; Panda, S.S.; Swaroop Sanket, A.; Pati, S.; Chand Gupta, A.; Bawankule, D.U.; Chanda, D.; Kant, R.; Darokar, M.P. 2021: Design, synthesis and drug resistance reversal potential of novel curcumin mimics van D: Synergy potential of curcumin mimics. Bioorganic Chemistry 106: 104454
Zhao, S.; Li, X.; Wang, L.; Peng, W.; Ye, W.; Li, W.; Wang, Y.-D.; Chen, W.-D. 2021: Design, synthesis and evaluation of 1-benzyl-1H-imidazole-5-carboxamide derivatives as potent TGR5 agonists. Bioorganic and Medicinal Chemistry 32: 115972
Yan, L.; Cao, R.; Zhang, H.; Li, Y.; Li, W.; Li, X.; Fan, S.; Li, S.; Zhong, W. 2021: Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents. European Journal of Medicinal Chemistry 226: 113852
Lu, R.; Wang, Y.; Liu, C.; Zhang, Z.; Li, B.; Meng, Z.; Jiang, C.; Hu, Q. 2021: Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y14R antagonists with potential high efficiency against acute gouty arthritis. European Journal of Medicinal Chemistry 216: 113313
Orafaie, A.; Sadeghian, H.; Bahrami, A.R.; Rafatpanah, H.; Matin, M.M. 2021: Design, synthesis and evaluation of PD-L1 peptide antagonists as new anticancer agents for immunotherapy. Bioorganic and Medicinal Chemistry 30: 115951
Jia, D.; Dou, Y.; Li, Z.; Zhou, X.; Gao, Y.; Chen, K.; Cong, W.; Ma, M.; Wu, Z.; Li, W. 2020: Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. Bioorganic and Medicinal Chemistry 28(20): 115697
Reeh, K.; Summers, P.A.; Gould, I.R.; Woscholski, R.; Vilar, R. 2020: Design, synthesis and evaluation of a tripodal receptor for phosphatidylinositol phosphates. Scientific Reports 10(1): 18450
Zhou, Z.; He, J.; Yang, F.; Pan, Q.; Yang, Z.; Zheng, P.; Xu, S.; Zhu, W. 2021: Design, synthesis and evaluation of anti-proliferative activity of 2-aryl-4-aminoquinazoline derivatives as EGFR inhibitors. Bioorganic Chemistry 112: 104848
Wang, C.; Li, Y.; Liu, T.; Wang, Z.; Zhang, Y.; Bao, K.; Wu, Y.; Guan, Q.; Zuo, D.; Zhang, W. 2020: Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles. Bioorganic Chemistry 104: 103909
Djuidje, E.N.; Sciabica, S.; Buzzi, R.; Dissette, V.; Balzarini, J.; Liekens, S.; Serra, E.; Andreotti, E.; Manfredini, S.; Vertuani, S.; Baldisserotto, A. 2020: Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents. Bioorganic Chemistry 101: 103960
An, L.; Wang, C.; Zheng, Y.-G.; Liu, J.-D.; Huang, T.-H. 2021: Design, synthesis and evaluation of calix[4]arene-based carbonyl amide derivatives with antitumor activities. European Journal of Medicinal Chemistry 210: 112984
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Da Silva, G.M.; de Souza, D.H.B.; Waitman, K.B.; Ebram, M.C.; Fessel, M.R.; Zainescu, I.C.; Portaro, F.C.; Heras, M.; de Andrade, S.A. 2021: Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors. Journal of Venomous Animals and Toxins Including Tropical Diseases 27: E20200066
Senapathi, J.; Bommakanti, A.; Vangara, S.; Kondapi, A.K. 2021: Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions. Bioorganic Chemistry 116: 105313
Choubey, P.K.; Tripathi, A.; Tripathi, M.K.; Seth, A.; Shrivastava, S.K. 2021: Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer's disease. Bioorganic Chemistry 111: 104922
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Fukai, R.; Ogo, N.; Ichida, T.; Yamane, M.; Sawada, J.-I.; Miyoshi, N.; Murakami, H.; Asai, A. 2021: Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein. European Journal of Medicinal Chemistry 215: 113288
Lin, S.; Chen, Y.; Li, H.; Liu, J.; Liu, S. 2020: Design, synthesis, and evaluation of amphiphilic sofalcone derivatives as potent Gram-positive antibacterial agents. European Journal of Medicinal Chemistry 202: 112596
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Stephenson, A.A.; Cao, S.; Taggart, D.J.; Vyavahare, V.P.; Suo, Z. 2021: Design, synthesis, and evaluation of liver-specific gemcitabine prodrugs for potential treatment of hepatitis C virus infection and hepatocellular carcinoma. European Journal of Medicinal Chemistry 213: 113135
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Dung, D.T.M.; Park, E.J.; Anh, D.T.; Hai, P.-T.; Huy, L.D.; Jun, H.W.; Kwon, J.-H.; Young Ji, A.; Kang, J.S.; Tung, T.T.; Dung, P.T.P.; Han, S.-B.; Nam, N.-H. 2022: Design, synthesis, and evaluation of novel (E)-N'-(3-allyl-2-hydroxy)benzylidene-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as antitumor agents. Archiv der Pharmazie 355(1): E2100216
Huan, L.Cong.; Anh, D.Tien.; Hai, P-The.; Anh, L.Duc.; Park, E.Jae.; Ji, A.Young.; Kang, J.Soon.; Dung, D.Thi.Mai.; Oanh, D.Thi.Kim.; Tung, T.Thanh.; Hai, D.Thi.Thanh.; Han, S-Bae.; Nam, N-Hai. 2020: Design, synthesis, and evaluation of novel N' -substituted-1-(4-chlorobenzyl)-1 H -indol-3-carbohydrazides as antitumor agents. Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1854-1865
Zhu, H.; Ying, S.; Zhou, B.; Hu, X.; Liang, X.; Li, W.; Wang, D.; Jin, H.; Pan, Y. 2021: Design, synthesis, and evaluation of novel coumarin-dithiocarbamate derivatives (IDs) as anti-colorectal cancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 593-604
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Asadi, M.; Mohammadi-Khanaposhtani, M.; Hosseini, F.S.; Gholami, M.; Dehpour, A.R.; Amanlou, M. 2021: Design, synthesis, and evaluation of novel racecadotril-tetrazole-amino acid derivatives as new potent analgesic agents. Research in Pharmaceutical Sciences 16(4): 341-357
Sayer, J.R.; Walldén, K.; Koss, H.; Allan, H.; Daviter, T.; Gane, P.J.; Waksman, G.; Tabor, A.B. 2021: Design, synthesis, and evaluation of peptide-imidazo[1,2-a]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525. Journal of Peptide Science: An Official Publication of the European Peptide Society 27(10): E3353
Yuen, R.; Wagner, M.; Richter, S.; Dufour, J.; Wuest, M.; West, F.G.; Wuest, F. 2021: Design, synthesis, and evaluation of positron emission tomography/fluorescence dual imaging probes for targeting facilitated glucose transporter 1 (GLUT1). Organic and Biomolecular Chemistry 19(14): 3241-3254
Yu, J.; Li, S.; Zeng, X.; Song, J.; Hu, S.; Cheng, S.; Chen, C.; Luo, H.; Pan, W. 2021: Design, synthesis, and evaluation of proliferation inhibitory activity of novel L-shaped ortho-quinone analogs as anticancer agents. Bioorganic Chemistry 117: 105383
Li, Z.; Wang, X.; Lin, Y.; Wang, Y.; Wu, S.; Xia, K.; Xu, C.; Ma, H.; Zheng, J.; Luo, L.; Zhu, F.; He, S.; Zhang, X. 2020: Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity. European Journal of Medicinal Chemistry 205: 112537
Li, D.; Liu, C.; Jiang, X.; Lin, Y.; Zhang, J.; Li, Y.; You, X.; Jiang, W.; Chen, M.; Xu, Y.; Si, S. 2021: Design, synthesis, and evaluation of substituted 2-acylamide-1,3-benzo[d]zole analogues as agents against MDR- and XDR-MTB. European Journal of Medicinal Chemistry 209: 112898
Gonzalez, S.N.; Mills, J.J.; Maugeri, D.; Olaya, C.; Laguera, B.L.; Enders, J.R.; Sherman, J.; Rodriguez, A.; Pierce, J.G.; Cazzulo, J.J.é; D'Antonio, E.L. 2021: Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B. Bioorganic and Medicinal Chemistry Letters 32: 127723
Higgins, E.L.; Kellner-Rogers, J.S.; Estanislau, A.M.; Esposito, A.C.; Vail, N.R.; Payne, S.R.; Stockwell, J.G.; Ulrich, S.M. 2021: Design, synthesis, and evaluation of transition-state analogs as inhibitors of the bacterial quorum sensing autoinducer synthase Cepi. Bioorganic and Medicinal Chemistry Letters 39: 127873
Nagaoka, Y.; Parvatkar, P.; Hirai, G.; Ohkanda, J. 2021: Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B. Bioorganic and Medicinal Chemistry Letters 48: 128265
Istanbullu, H.; Bayraktar, G.; Akbaba, H.; Cavus, I.; Coban, G.; Debelec Butuner, B.; Kilimcioglu, A.A.; Ozbilgin, A.; Alptuzun, V.; Erciyas, E. 2020: Design, synthesis, and in vitro biological evaluation of novel thiazolopyrimidine derivatives as antileishmanial compounds. Archiv der Pharmazie 353(8): E1900325
Ye, C.; Xu, R.; Cao, Z.; Song, Q.; Yu, G.; Shi, Y.; Liu, Z.; Liu, X.; Deng, Y. 2021: Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents. Bioorganic Chemistry 111: 104895
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Wang, D.-P.; Liu, K.-L.; Li, X.-Y.; Lu, G.-Q.; Xue, W.-H.; Qian, X.-H.; Mohamed O, K.; Meng, F.-H. 2021: Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold. European Journal of Medicinal Chemistry 211: 113083
Oleksak, P.; Psotka, M.; Vancurova, M.; Sapega, O.; Bieblova, J.; Reinis, M.; Rysanek, D.; Mikyskova, R.; Chalupova, K.; Malinak, D.; Svobodova, J.; Andrys, R.; Rehulkova, H.; Skopek, V.; Ngoc Lam, P.; Bartek, J.; Hodny, Z.; Musilek, K. 2021: Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 410-424
Corrigan, T.S.; Lotti Diaz, L.M.; Border, S.E.; Ratigan, S.C.; Kasper, K.Q.; Sojka, D.; Fajtova, P.; Caffrey, C.R.; Salvesen, G.S.; McElroy, C.A.; Hadad, C.M.; Doğan Ekici, Özlem. 2020: Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1387-1402
Zhang, X.; Sun, L.; Meuser, M.E.; Zalloum, W.A.; Xu, S.; Huang, T.; Cherukupalli, S.; Jiang, X.; Ding, X.; Tao, Y.; Kang, D.; De Clercq, E.; Pannecouque, C.; Dick, A.; Cocklin, S.; Liu, X.; Zhan, P. 2021: Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors. European Journal of Medicinal Chemistry 226: 113848
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Koksal, M.; Dedeoglu-Erdogan, A.; Bader, M.; Gurdal, E.E.; Sippl, W.; Reis, R.; Ozgurbuz, M.; Sipahi, H.; Celik, T. 2021: Design, synthesis, and molecular docking of novel 3,5-disubstituted-1,3,4-oxadiazole derivatives as iNOS inhibitors. Archiv der Pharmazie 354(8): E2000469
Nazreen, S. 2021: Design, synthesis, and molecular docking studies of thiazolidinediones as PPAR-γ agonists and thymidylate synthase inhibitors. Archiv der Pharmazie 354(9): e2100021
El-Hamamsy, M.H.; Sharafeldin, N.A.; El-Moselhy, T.F.; Tawfik, H.O. 2020: Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors. Archiv der Pharmazie 353(8): E2000060
Insuasty, D.; García, S.; Abonia, R.; Insuasty, B.; Quiroga, J.; Nogueras, M.; Cobo, J.; Borosky, G.L.; Laali, K.K. 2021: Design, synthesis, and molecular docking study of novel quinoline-based bis-chalcones as potential antitumor agents. Archiv der Pharmazie 354(9): E2100094
Kavalapure, R.S.; Alegaon, S.G.; Venkatasubramanian, U.; Priya, A.S.; Ranade, S.D.; Khanal, P.; Mishra, S.; Patil, D.; Salve, P.S.; Jalalpure, S.S. 2021: Design, synthesis, and molecular docking study of some 2-((7-chloroquinolin-4-yl) amino) benzohydrazide Schiff bases as potential Eg5 inhibitory agents. Bioorganic Chemistry 116: 105381
Singh, V.K.; Chaurasia, H.; Kumari, P.; Som, A.; Mishra, R.; Srivastava, R.; Naaz, F.; Singh, A.; Singh, R.K. 2021: Design, synthesis, and molecular dynamics simulation studies of quinoline derivatives as protease inhibitors against SARS-CoV-2. Journal of Biomolecular Structure and Dynamics 2021: 1-24
Liang, L.; Yu, S.; Li, Q.; Wang, X.; Wang, D.; Xi, Z. 2021: Design, synthesis, and molecular simulation studies of N-phenyltetrahydroquinazolinones as protoporphyrinogen IX oxidase inhibitors. Bioorganic and Medicinal Chemistry 39: 116165