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Investigations on the organic drift in North Swedish streams
Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research
Phloem necrosis of coffee in Surinam
Anatomy of Mystus seenghala IV Nervous system
Integrated farming system for gardenland conditions of Coimbatore district - an over view
Tetrapleure (Tetrapleura tetraptera), an unknown African medicinal and spice plant
The origin and phylogenetic significance of the trochophoran larvae 2. evolutionary significance of the larvae of coelomate worms and mollusks
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
Enterobacter amnigenus. An unusual human pathogen
Influence of Seriboost foliar application on leaf yield and leaf protein content in mulberry (Morus spp.), in relation to silkworm cocoon production
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
'Pan-sukh' disease of Rice in the Central Provinces
Geological age of the Ptilophyllum flora; a critical reassessment
Study of vitellogenesis in birds; physiological phases & role of folliculin in vitellogenesis
Evaluation of WCT coconut and Komadan coconut
Therapy for acne with saccharomyces boulardii
Evidence for Late Cretaceous N-S dextral shear in the west-central crystalline core, North Cascades, Washington
'Rajeshwari' - a high-yielding white seeded variety of sesame for Andhra Pradesh
Manufacture of Ricotta cheese from whey fortified with skim milk powder using different acidulants
Occurrence of Eutrichophilus mexicanus (Rudow, 1866) and Eutrichophilus lobatus (Ewing, 1936) (Phthiraptera: Trichodectidae) on Sphiggurus villosus (Cuvier, 1825) (Rodentia: Erethizontidae) in Rio de
Factors affecting fruitfulness in durian (Durio zibethinus Murr.). I. Flowering and pollination
Bronchial cuff pressure change caused by left-sided double-lumen endobronchial tube displacement
Some Biological Applications of Organometallic Compounds
The composition of pampas-grass (Cortaderia argentea.)

List of PDF Full Texts available from EurekaMag Chapter 71565

Chapter 71565 contains a list of PDF Full Texts available from EurekaMag.




Design of bioluminescent biosensors for assessing contamination of complex matrices
, Talanta 233: 122509 (2021)

Design of biotin decorated enterocyte targeting muco-inert nanocomplexes for enhanced oral insulin delivery
, Carbohydrate Polymers 261: 117873 (2021)

Design of brain-computer interface-based classification model for mining mental state of COVID-19 afflicted mariner's
, International Maritime Health 71(4): 298-300 (2020)

Design of broadband graphene-metamaterial absorbers for permittivity sensing at mid-infrared regions
, Scientific Reports 8(1): 4183 (2018)

Design of buried charged networks in artificial proteins
, Nature Communications 12(1): 1895 (2021)

Design of cancer assays for pharmaceutical agents
, Journal of the National Cancer Institute 72(6): 1212 (1984)

Design of capillary microfluidics for spinning cell-laden microfibers
, Nature Protocols 13(11): 2557-2579 (2018)

Design of carbon supports for metal-catalyzed acetylene hydrochlorination
, Nature Communications 12(1): 4016 (2021)

Design of carboxylated single-walled carbon nanotubes as highly efficient inhibitors against Aβ40 fibrillation based on the HyBER mechanism
, Journal of Materials Chemistry. B 9(34): 6902-6914 (2021)

Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C-H bonds
, Nature Chemistry 10(10): 1048-1055 (2018)

Design of chimeric antigen receptors with integrated controllable transient functions
, Scientific Reports 6: 18950 (2016)

Design of chitosan nanocomposite hydrogel for sensitive detection and removal of organic pollutants
, International Journal of Biological Macromolecules 159: 276-286 (2020)

Design of circular-ring film embedded contact lens for improved compatibility and sustained ocular drug delivery
, European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 157: 28-37 (2020)

Design of clinical trials evaluating dietary interventions in patients with functional gastrointestinal disorders
, American Journal of Gastroenterology 108(5): 748-758 (2013)

Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo
, Nature Biotechnology 35(11): 1094-1101 (2017)

Design of combined lower limb elastic compression device and comparative study with elastic bandage
, Zhongguo Gu Shang 34(3): 243-248 (2021)

Design of commercially comparable nanotherapeutic agent against human disease-causing parasite, Leishmania
, Scientific Reports 8(1): 8814 (2018)

Design of compensated ferrimagnetic Heusler alloys for giant tunable exchange bias
, Nature Materials 14(7): 679-684 (2015)

Design of composite measure schemes for comparative severity assessment in animal-based neuroscience research: A case study focussed on rat epilepsy models
, Plos one 15(5): E0230141 (2020)

Design of condition-based maintenance framework for process operations management in pharmaceutical continuous manufacturing
, International Journal of Pharmaceutics 587: 119621 (2020)

Design of configuration-restricted triazolylated β-d-ribofuranosides: a unique family of crescent-shaped RNase A inhibitors
, Organic and Biomolecular Chemistry 18(32): 6340-6356 (2020)

Design of conical hollow ZnS arrays vertically grown on carbon fibers for lightweight and broadband flexible absorbers
, Journal of Colloid and Interface Science 607(Pt 2): 1287-1299 (2021)

Design of continuously variant metasurfaces for conformal transformation optics
, Optics Express 28(23): 34201-34218 (2020)

Design of crystal-like aperiodic solids with selective disorder-phonon coupling
, Nature Communications 7: 10445 (2016)

Design of custom-made navigational template of femoral head and pilot research in total hip resurfacing arthroplasty
, Bmc Surgery 20(1): 144 (2020)

Design of defect spins in piezoelectric aluminum nitride for solid-state hybrid quantum technologies
, Scientific Reports 6: 20803 (2016)

Design of defect-chemical properties and device performance in memristive systems
, Science Advances 6(19): Eaaz9079 (2020)

Design of dental implant using design of experiment and topology optimization: A finite element analysis study
, Proceedings of the Institution of Mechanical Engineers. Part H Journal of Engineering in Medicine 2020: 954411920967146 (2020)

Design of denture frameworks
, Rivista Italiana Degli Odontotecnici 18(2): 4 (1982)

Design of deterministic light-trapping structures for thin silicon heterojunction solar cells
, Optics Express 29(5): 7410-7417 (2021)

Design of dialdehyde cellulose crosslinked poly(vinyl alcohol) hydrogels for transdermal drug delivery and wound dressings
, Materials Science and Engineering. C Materials for Biological Applications 116: 111242 (2020)

Design of diffractive lenses operating at several wavelengths
, Optics Express 28(8): 11705-11720 (2020)

Design of dispersant for highly concentrated one-dimensional Nb 2 Se 9 inorganic molecular chains from bulk crystal
, Scientific Reports 9(1): 14579 (2019)

Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
, Acta Pharmaceutica Sinica. B 10(7): 1309-1320 (2020)

Design of drug-loaded 3D printing biomaterial inks and tailor-made pharmaceutical forms for controlled release
, International Journal of Pharmaceutics 609: 121124 (2021)

Design of dual hormone blood glucose therapy and comparison with single hormone using MPC algorithm
, Iet Systems Biology 14(5): 241-251 (2020)

Design of dual-band cold mirrors
, Scientific Reports 7(1): 15402 (2017)

Design of easy-manufacturing superdirective antenna: a theoretical study
, Applied Optics 59(27): 8302-8309 (2020)

Design of effective immunotherapy for human autoimmunity
, Nature 435(7042): 612-619 (2005)

Design of efficacious somatic cell genome editing strategies for recessive and polygenic diseases
, Nature Communications 11(1): 6277 (2020)

Design of efficient molecular organic light-emitting diodes by a high-throughput virtual screening and experimental approach
, Nature Materials 15(10): 1120-1127 (2016)

Design of electroencephalogram authentication access control to smart car
, Healthcare Technology Letters 7(4): 109-113 (2020)

Design of engineered surfaces for prospective detection of SARS-CoV-2 using quartz crystal microbalance-based techniques
, Expert Review of Proteomics 17(6): 425-432 (2020)

Design of enzyme-responsive short-chain fatty acid-based self-assembling drug for alleviation of type 2 diabetes mellitus
, Biomaterials 275: 120877 (2021)

Design of epidermal growth factor immobilization on 3D biocompatible scaffolds to promote tissue repair and regeneration
, Scientific Reports 11(1): 2629 (2021)

Design of experiment (DoE)-driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copper-free click chemistry-based labelling
, Journal of Extracellular Vesicles 9(1): 1779458 (2020)

Design of experiments and design space approaches in the pharmaceutical bioprocess optimization
, European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 2021 (2021)

Design of experiments applied to stress testing of pharmaceutical products: A case study of Albendazole
, European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 2021: 105939 (2021)

Design of experiments for development and optimization of a liquid chromatography coupled to tandem mass spectrometry bioanalytical assay
, Journal of Mass Spectrometry 2021: e4727 (2021)

Design of experiments for the optimization of SOFI super-resolution microscopy imaging
, Biomedical Optics Express 12(5): 2617-2630 (2021)

Design of experiments guided multivariate calibration for the quantitation of injectable colistimethate sodium by ultra performance liquid chromatography - High resolution mass spectrometry
, Talanta 220: 121406 (2020)

Design of experiments-based high-throughput strategy for development and optimization of efficient cell disruption protocols
, Engineering in Life Sciences 17(11): 1166-1172 (2017)

Design of expert guided investigation of native L-asparaginase encapsulated long-acting cross-linker-free poly (lactic-co-glycolic) acid nanoformulation in an Ehrlich ascites tumor model
, Saudi Pharmaceutical Journal: Spj: the Official Publication of the Saudi Pharmaceutical Society 28(6): 719-728 (2020)

Design of facile technology for the efficient removal of hydroxypropyl guar gum from fracturing fluid
, Plos one 16(3): E0247948 (2021)

Design of fast proteolysis-based signaling and logic circuits in mammalian cells
, Nature Chemical Biology 15(2): 115-122 (2019)

Design of financial incentive interventions to improve lifestyle behaviors and health outcomes: A systematic review
, Wellcome Open Research 6: 163 (2021)

Design of fluorescent protein-based sensors through a general protection-deprotection strategy
, Methods in Enzymology 640: 63-82 (2020)

Design of fractional evolutionary processing for reactive power planning with FACTS devices
, Scientific Reports 11(1): 593 (2021)

Design of freeform geometries in a MEMS accelerometer with a mechanical motion preamplifier based on a genetic algorithm
, Microsystems and Nanoengineering 6: 104 (2020)

Design of freeform lenses for illuminating hard-to-reach areas through a light-guiding system
, Optics Express 28(25): 38155-38168 (2020)

Design of freeforms to uniformly illuminate polygonal targets from extended sources via edge ray mapping
, Applied Optics 59(22): 6490-6496 (2020)

Design of full-k-space flat bands in photonic crystals beyond the tight-binding picture
, Scientific Reports 5: 18181 (2015)

Design of functional metalloproteins
, Nature 460(7257): 855-862 (2009)

Design of gene circuits: lessons from bacteria
, Nature Reviews. Genetics 5(1): 34-42 (2004)

Design of ghost-free floating 3D display with narrow thickness using offset lens and dihedral corner reflector arrays
, Optics Express 28(10): 15691-15705 (2020)

Design of glycosylation sites by rapid synthesis and analysis of glycosyltransferases
, Nature Chemical Biology 14(6): 627-635 (2018)

Design of gossypetin derivatives based on naturally occurring flavonoid in Hibiscus sabdariffa and the molecular docking as antibacterial agents
, Journal of Basic and Clinical Physiology and Pharmacology 32(4): 707-714 (2021)

Design of gp120 HIV-1 entry inhibitors by scaffold hopping via isosteric replacements
, European Journal of Medicinal Chemistry 224: 113681 (2021)

Design of green coating material of combining rigid and flexible properties for the extraction of aminoglycosides residues
, Journal of Chromatography A 1641: 462006 (2021)

Design of growth factor antagonists with antiangiogenic and antitumor properties
, Oncogene 19(56): 6566-6573 (2000)

Design of helical linkers for fusion proteins and protein-based nanostructures
, Methods in Enzymology 647: 209-230 (2021)

Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
, Nature Communications 11(1): 2562 (2020)

Design of high-ductile medium entropy alloys for dental implants
, Materials Science and Engineering. C Materials for Biological Applications 113: 110959 (2020)

Design of high-order antibiotic combinations against M. tuberculosis by ranking and exclusion
, Scientific Reports 9(1): 11876 (2019)

Design of high-performance curling mascara through utilization of smart thermoresponsive polymer
, International Journal of Cosmetic Science 42(6): 557-563 (2020)

Design of highly efficient deep-blue organic afterglow through guest sensitization and matrices rigidification
, Nature Communications 11(1): 4802 (2020)

Design of highly efficient g-C 3 N 4 -based metal monoatom catalysts by two extra-NM 1 atoms: density functional theory simulations
, Physical Chemistry Chemical Physics: Pccp 2021 (2021)

Design of highly efficient phosphor-converted white light-emitting diodes with color rendering indices (R 1 - R 15 ) ≥ 95 for artificial lighting
, Scientific Reports 9(1): 16848 (2019)

Design of highly sensitive refractive index sensors in the visible region utilizing metal layer assisted guided modes
, Applied Optics 60(25): 7589-7595 (2021)

Design of huantai childhood cardiovascular health cohort study
, Zhonghua Yu Fang Yi Xue Za Zhi 54(12): 1461-1464 (2020)

Design of improved pET expression plasmids
, Nature Methods 17(7): 655 (2020)

Design of industrial wastewater demulsifier by HLD-NAC model
, Scientific Reports 11(1): 16111 (2021)

Design of infusion regimens to achieve and maintain a predetermined plasma drug level range
, Clinical Pharmacology and Therapeutics 28(3): 289-295 (1980)

Design of intrinsically stretchable and highly conductive polymers for fully stretchable electrochromic devices
, Scientific Reports 10(1): 16488 (2020)

Design of iso-material heterostructures of TiO 2 via seed mediated growth and arrested phase transitions
, Physical Chemistry Chemical Physics: Pccp 22(43): 25366-25379 (2020)

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness
, Nature Chemical Biology 5(2): 108-117 (2009)

Design of light/ROS cascade-responsive tumor-recognizing nanotheranostics for spatiotemporally controlled drug release in locoregional photo-chemotherapy
, Acta Biomaterialia 111: 327-340 (2020)

Design of liposomes as drug delivery system for therapeutic applications
, International Journal of Pharmaceutics 2021: 120571 (2021)

Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy
, Nature Communications 8: 15480 (2017)

Design of long acting invasomal nanovesicles for improved transdermal permeation and bioavailability of asenapine maleate for the chronic treatment of schizophrenia
, International Journal of Pharmaceutics 2021: 121080 (2021)

Design of long-wavelength emission carbon dots for hypochlorous detection and cellular imaging
, Talanta 219: 121170 (2020)

Design of low loss 1 × 1 and 1 × 2 phase-change optical switches with different crystalline phases of Ge 2 Sb 2 Te 5 films
, Nanotechnology 31(45): 455206 (2020)

Design of magnetic hybrid nanostructured lipid carriers containing 1,8-cineole as delivery systems for anticancer drugs: Physicochemical and cytotoxic studies
, Colloids and Surfaces. B Biointerfaces 202: 111710 (2021)

Design of magnetic polyplexes taken up efficiently by dendritic cell for enhanced DNA vaccine delivery
, Gene Therapy 21(2): 212-218 (2014)

Design of materials with supramolecular polymers
, Progress in Polymer Science 111: 101310 (2020)

Design of metacontinua in the aeroacoustic spacetime
, Scientific Reports 10(1): 18192 (2020)

Design of metalloproteins and novel protein folds using variational autoencoders
, Scientific Reports 8(1): 16189 (2018)

Design of metastable oxychalcogenide phases by topochemical (de)intercalation of sulfur in La 2 O 2 S 2
, Nature Communications 12(1): 3605 (2021)

Design of micromagnetic arrays for on-chip separation of superparamagnetic bead aggregates and detection of a model protein and double-stranded DNA analytes
, Scientific Reports 11(1): 5302 (2021)

Design of microstructure for hollow fiber loose nanofiltration separation layer and its compactness-tailoring mechanism
, Journal of Hazardous Materials 421: 126800 (2021)

Design of mid-infrared filter array based on plasmonic metal nanodiscs array and its application to on-chip spectrometer
, Scientific Reports 11(1): 12218 (2021)

Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability
, Bioorganic Chemistry 111: 104835 (2021)

Design of multi-epitope vaccine candidate against SARS-CoV-2: a in-silico study
, Journal of Biomolecular Structure and Dynamics 2020: 1-9 (2020)

Design of multi-particulate "Dome matrix" with sustained-release melatonin and delayed-release caffeine for jet lag treatment
, International Journal of Pharmaceutics 587: 119618 (2020)

Design of multi-phase dynamic chemical networks
, Nature Chemistry 9(8): 799-804 (2017 )

Design of multi-scale protein complexes by hierarchical building block fusion
, Nature Communications 12(1): 2294 (2021)

Design of Multidrug-Resistant Tuberculosis Treatment Regimens Based on DNA Sequencing
, Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2021 (2021)

Design of multilayer optical thin-films based on light scattering properties and using deep neural networks
, Optics Express 29(20): 32627-32638 (2021)

Design of multivalent complexes using the barnase*barstar module
, Nature Biotechnology 21(12): 1486-1492 (2003)

Design of mutants of GH11 xylanase from Bacillus pumilus for enhanced stability by amino acid substitutions in the N-terminal region: an in silico analysis
, Journal of Biomolecular Structure and Dynamics 2021: 1-14 (2021)

Design of nano-clays for drug delivery and bio-imaging: can toxicity be an issue?
, Nanomedicine 15(25): 2429-2432 (2020)

Design of nanoemulgel using Argania spinosa microfibrillated cellulose and natural emulsifiers foreseeing melanogenesis enhancement
, Carbohydrate Polymers 274: 118632 (2021)

Design of nanomaterials for applications in maternal/fetal medicine
, Journal of Materials Chemistry. B 8(31): 6548-6561 (2020)

Design of nanoscaled heterojunctions in precursor-derived t-ZrO 2 /SiOC(N) nanocomposites: Transgressing the boundaries of catalytic activity from UV to visible light
, Scientific Reports 10(1): 430 (2020)

Design of nanostructure chitosan hydrogels for carrying zinc phthalocyanine as a photosensitizer and difloxacin as an antibacterial agent
, International Journal of Biological Macromolecules 159: 598-606 (2020)

Design of naturally inspired jellyfish-shaped cyclopolylactides to manage osteosarcoma cancer stem cells fate
, Materials Science and Engineering. C Materials for Biological Applications 117: 111291 (2020)

Design of new Mott multiferroics via complete charge transfer: promising candidates for bulk photovoltaics
, Scientific Reports 7(1): 6142 (2017)

Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation
, Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1840-1853 (2020)

Design of new lipids from bovine milk fat for baby nutrition
, Critical Reviews in Food Science and Nutrition 2020: 1-15 (2020)

Design of next-generation ceramic fuel cells and real-time characterization with synchrotron X-ray diffraction computed tomography
, Nature Communications 10(1): 1497 (2019)

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics
, Mabs 12(1): 1829338 (2020)

Design of nickel cobalt molybdate regulated by boronizing for high-performance supercapacitor applications
, Nanoscale 12(34): 17849-17857 (2020)

Design of non-autonomous pH oscillators and the existence of chemical beat phenomenon in a neutralization reaction
, Scientific Reports 11(1): 11011 (2021)

Design of non-equiatomic medium-entropy alloys
, Scientific Reports 8(1): 1236 (2018)

Design of non-viral vector with improved regulatory features towards therapeutic application
, Bioinformation 16(4): 307-313 (2020)

Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia
, Leukemia 26(9): 2032-2038 (2012)

Design of novel CNT/RGO/ZIF-8 ternary hybrid structure for lightweight and highly effective microwave absorption
, Nanotechnology 31(41): 414001 (2020)

Design of novel ROCK inhibitors using fragment-based de novo drug design approach
, Journal of Molecular Modeling 26(9): 249 (2020)

Design of novel Xenopus GLP-1-based dual glucagon-like peptide 1 (GLP-1)/glucagon receptor agonists
, European Journal of Medicinal Chemistry 212: 113118 (2020)

Design of novel conjugated microporous polymers for efficient adsorptive desulfurization of small aromatic sulfur molecules
, Journal of Molecular Graphics and Modelling 101: 107734 (2020)

Design of novel granulopoietic proteins by topological rescaffolding
, Plos Biology 18(12): E3000919 (2020)

Design of novel materials for additive manufacturing - Isotropic microstructure and high defect tolerance
, Scientific Reports 8(1): 1298 (2018)

Design of novel molecules with considerable optical properties based on polymer of BODIPY molecules
, Journal of Molecular Modeling 26(11): 306 (2020)

Design of novel multiepitope constructs-based peptide vaccine against the structural S, N and M proteins of human COVID-19 using immunoinformatics analysis
, Plos one 15(10): E0240577 (2020)

Design of novel oral ricobendazole formulation applying melting solidification printing process (MESO-PP): An innovative solvent-free alternative method for 3D printing using a simplified concept and low temperature
, International Journal of Pharmaceutics 587: 119653 (2020)

Design of novel orotransmucosal vaccine-delivery platforms using artificial intelligence
, European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 2020 (2020)

Design of novel peptide inhibitors against the conserved bacterial transcription terminator, Rho
, Journal of Biological Chemistry 202(1): 100653 (2021)

Design of novel protein building modules and modular architectures
, Current Opinion in Structural Biology 63: 90-96 (2020)

Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1
, Computational and Structural Biotechnology Journal 19: 51-61 (2021)

Design of novel substituted phthalocyanines; synthesis and fluorescence, DFT, photovoltaic properties
, Turkish Journal of Chemistry 44(6): 1574-1586 (2020)

Design of novel super wide band antenna close to the fundamental dimension limit theory
, Scientific Reports 10(1): 16306 (2020)

Design of novel viral attachment inhibitors of the spike glycoprotein (S) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) through virtual screening and dynamics
, International Journal of Antimicrobial Agents 56(6): 106177 (2020)

Design of ocular drug delivery platforms and in vitro - in vivo evaluation of riboflavin to the cornea by non-interventional (epi-on) technique for keratoconus treatment
, Journal of Controlled Release: Official Journal of the Controlled Release Society 324: 238-249 (2020)

Design of on-chip N-fold orbital angular momentum multicasting using V-shaped antenna array
, Scientific Reports 5: 9662 (2015)

Design of on-chip mid-IR frequency comb with ultra-low power pump in near-IR
, Optics Express 28(21): 30771-30783 (2020)

Design of on-chip polarimetry with Stokes-determined silicon photonic circuits
, Optics Express 29(20): 31026-31035 (2021)

Design of opposite thermal behaviors in Tm 3+ /Eu 3+ co-doped YVO 4 for high-sensitivity optical thermometry
, Optics Letters 46(6): 1301-1304 (2021)

Design of optical cavity for air sanification through ultraviolet germicidal irradiation
, Optics Express 29(12): 18688-18704 (2021)

Design of optical meta-structures with applications to beam engineering using deep learning
, Scientific Reports 10(1): 19923 (2020)

Design of optimal digital filter and digital signal processing for a CdZnTe high resolution gamma-ray system
, Applied Radiation and Isotopes: Including Data Instrumentation and Methods for use in Agriculture Industry and Medicine 162: 109171 (2020)

Design of optimal noise hazard control strategy with budget constraint
, International Journal of Occupational Safety and Ergonomics: Jose 17(4): 463-464 (2011)

Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters
, Molecular Systems Biology 9: 702 (2013)

Design of orthogonal regulatory systems for modulating gene expression in plants
, Nature Chemical Biology 16(8): 857-865 ( 2020)

Design of pH-Degradable Polymer-Lipid Amphiphiles Using a Ketal-Functionalized RAFT Chain Transfer Agent
, Macromolecular Rapid Communications 42(2): E2000696 (2021)

Design of partial metal prostheses
, Maroc Medical 33(346): 276-290 (1954)

Design of pathology request forms
, Lancet 342(8871): 620-621 (1993)

Design of patient specific bone stiffness mimicking scaffold
, Proceedings of the Institution of Mechanical Engineers. Part H Journal of Engineering in Medicine 2021: 9544119211030715 (2021)

Design of peptide-based inhibitor agent against amyloid-β aggregation: Molecular docking, synthesis and in vitro evaluation
, Bioorganic Chemistry 102: 104050 (2020)

Design of peptides with high affinity binding to a monoclonal antibody as a basis for immunotherapy
, Peptides 2021: 170628 (2021)

Design of personalized cancer treatments by use of optimal control problems: The case of chronic myeloid leukemia
, Mathematical Biosciences and Engineering: Mbe 17(5): 4773-4800 (2020)

Design of phase 2 study of TAS-115, a novel oral multi-kinase inhibitor, in patients with idiopathic pulmonary fibrosis
, Contemporary Clinical Trials Communications 23: 100832 (2021)

Design of phase-transition molecular solar thermal energy storage compounds: compact molecules with high energy densities
, Chemical Communications 57(74): 9458-9461 (2021)

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
, Nature Biotechnology 28(1): 63-70 (2010)

Design of phosphorodiamidate morpholino oligomers (PMOs) for the induction of exon skipping of the human DMD gene
, Molecular Therapy: the Journal of the American Society of Gene Therapy 17(3): 554-561 (2009)

Design of phosphoryl containing podands with Li + /Na + selectivity using machine learning
, Sar and Qsar in Environmental Research 32(7): 521-539 (2021)

Design of photonic crystal nonlinear laser power limiter based on topological edge states and optical Kerr effect
, Optics Express 28(8): 12080-12092 (2020)

Design of phoxonic virtual waveguides for both electromagnetic and elastic waves based on the self-collimation effect: an application to enhance acousto-optic interaction
, Optics Express 28(17): 24813-24819 (2020)

Design of planar and wideangle resonant color absorbers for applications in the visible spectrum
, Scientific Reports 9(1): 7045 (2019)

Design of plasmonic Ag-TiO 2 /H 3 PW 12 O 40 composite film with enhanced sunlight photocatalytic activity towards o-chlorophenol degradation
, Scientific Reports 7(1): 17298 (2017)

Design of polarization-insensitive high-visibility silicon-on-insulator quantum interferometer
, Scientific Reports 8(1): 14613 (2018)

Design of poly ionic liquids modified cotton fabric with ion species-triggered bidirectional oil-water separation performance
, Journal of Hazardous Materials 400: 123163 (2020)

Design of poly-l-glutamic acid embedded mesoporous bioactive glass nanospheres for pH-stimulated chemotherapeutic drug delivery and antibacterial susceptibility
, Colloids and Surfaces. B Biointerfaces 202: 111700 (2021)

Design of polymer-free Vitamin-A acetate/cyclodextrin nanofibrous webs: antioxidant and fast-dissolving properties
, Food and Function 11(9): 7626-7637 (2020)

Design of polymeric core-shell carriers for combination therapies
, Journal of Colloid and Interface Science 587: 499-509 (2020)

Design of polyphenol-rich diets in clinical trials: A systematic review
, Food Research International 149: 110655 (2021)

Design of potent ABA receptor antagonists based on a conformational restriction approach
, Organic and Biomolecular Chemistry 18(26): 4988-4996 (2020)

Design of potent selective zinc-mediated serine protease inhibitors
, Nature 391(6667): 608-612 (1998)

Design of potentially universal SSU primers in myxomycetes using next-generation sequencing
, Journal of Microbiological Methods 2021: 106203 (2021)

Design of primers for direct sequencing of nine coding exons in the human ACVR1 gene
, Bone 138: 115469 (2020)

Design of prosthesis frameworks
, Rivista Italiana Degli Odontotecnici 18(4): 4 (1982)

Design of prosthesis frameworks
, Rivista Italiana Degli Odontotecnici 18(6): 4 (1982)

Design of protein switches based on an ensemble model of allostery
, Nature Communications 6: 6968 (2015)

Design of protein-interaction specificity gives selective bZIP-binding peptides
, Nature 458(7240): 859-864 (2009)

Design of protocols to evaluate the safety and efficacy of allergenic extracts
, Arbeiten aus dem Paul-Ehrlich-Institut dem Georg-Speyer-Haus und dem Ferdinand-Blum-Institut Zu Frankfurt A.M 1987(80): 229-237 (1987)

Design of pure heterodinuclear lanthanoid cryptate complexes
, Chemical Science 12(20): 6983-6991 (2021)

Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling
, European Journal of Medicinal Chemistry 215: 113252 (2021)

Design of radiative cooler based on porous TiO 2 for improving solar cells' performance
, Applied Optics 60(2): 445-451 (2021)

Design of ratiometric monoaromatic fluorescence probe via modulating intramolecular hydrogen bonding: A case study of alkaline phosphatase sensing
, Analytica Chimica Acta 1143: 144-156 (2021)

Design of realistic chewing trajectory for dynamic analysis of the dental prosthesis
, Acta of Bioengineering and Biomechanics 22(3): 77-84 (2020)

Design of reconfigurable on-chip wireless interconnections through Optical Phased Arrays
, Optics Express 29(20): 31212-31228 (2021)

Design of reflective phase retarders in the extreme ultraviolet based on chirped Mo/Si multilayer mirrors
, Journal of Synchrotron Radiation 28(Pt 5): 1437-1443 (2021)

Design of reinforcement learning for perimeter control using network transmission model based macroscopic traffic simulation
, Plos one 15(7): E0236655 (2020)

Design of robust 2,2'-bipyridine ligand linkers for the stable immobilization of molecular catalysts on silicon(111) surfaces
, Physical Chemistry Chemical Physics: Pccp 23(16): 9921-9929 (2021)

Design of robust superhydrophobic surfaces
, Nature 582(7810): 55-59 (2020)

Design of rough microgeometries for numerical simulation of material appearance
, Applied Optics 59(16): 4856-4864 (2020)

Design of selective nuclear receptor modulators: RAR and RXR as a case study
, Nature Reviews. Drug Discovery 6(10): 811-820 (2007)

Design of sensitizer with suitable frontier molecular orbital via substitution on starburst triphenylamine derivative
, Journal of Molecular Modeling 27(6): 167 (2021)

Design of si RNAs producing unstructured guide-RNAs results in improved RNA interference efficiency
, Nature Biotechnology 23(11): 1440-1444 (2005)

Design of single-layer beta-sheets without a hydrophobic core
, Nature 403(6768): 456-460 (2000)

Design of small molecules targeting RNA structure from sequence
, Chemical Society Reviews 49(20): 7252-7270 (2020)

Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations
, Chemical Communications 56(86): 13173-13176 (2020)

Design of stable biologically active recombinant lutropin analogs
, Nature Biotechnology 15(7): 663-667 (1997)

Design of stable metabolic networks
, Engineering in Life Sciences 17(8): 908-915 (2017)

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice
, Nature Biotechnology 37(10): 1186-1197 (2019)

Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling
, Cell Research 23(4): 581-584 (2013)

Design of steering wheel-type ring depressed-core 10-mode fiber with fully improved mode spacing
, Optics Express 29(10): 15067-15077 (2021)

Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold
, Scientific Reports 5: 12974 (2015)

Design of substrates and inhibitors of G protein-coupled receptor kinase 2 (GRK2) based on its phosphorylation reaction
, Amino Acids 52(6-7): 863-870 (2020)

Design of super-strong and thermally stable nanotwinned Al alloys via solute synergy
, Nanoscale 12(39): 20491-20505 (2020)

Design of superatomic systems: exploiting favourable conditions for the delocalisation of d-electron density in transition metal doped clusters
, Physical Chemistry Chemical Physics: Pccp 22(33): 18585-18594 (2020)

Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation
, Nature Communications 8: 15336 (2017)

Design of synthetic human gut microbiome assembly and butyrate production
, Nature Communications 12(1): 3254 (2021)

Design of synthetic yeast promoters via tuning of nucleosome architecture
, Nature Communications 5: 4002 (2014)

Design of task-specific optical systems using broadband diffractive neural networks
, Light Science and Applications 8: 112 (2019)

Design of terbium (III)-functionalized covalent organic framework as a selective and sensitive turn-on fluorescent switch for ochratoxin A monitoring
, Journal of Hazardous Materials 422: 126927 (2021)

Design of tethered bilayer lipid membranes, using wet chemistry via aryldiazonium sulfonic acid spontaneous grafting on silicon and chrome
, Colloids and Surfaces. B Biointerfaces 197: 111427 (2020)

Design of the "Thorough QT Study"
, Clinical Pharmacology and Therapeutics 83(4): 529; Author Reply 530 (2008)

Design of the Arizona CoVHORT: A Population-Based COVID-19 Cohort
, Frontiers in Public Health 9: 620060 (2021)

Design of the CAPABLE Health Empowerment Tool: Citizens' Needs and Expectations
, Studies in Health Technology and Informatics 270: 926-930 (2020)

Design of the Exercise Load Data Monitoring System for Exercise Training Based on the Neural Network
, Journal of Healthcare Engineering 2021: 7340140 (2021)

Design of the HEM-POWR study: a prospective, observational study of real-world treatment with damoctocog alfa pegol in patients with haemophilia A
, Bmj Open 11(9): E044997 (2021)

Design of the Hole-Injection/Hole-Transport Interfaces for Stable Quantum-Dot Light-Emitting Diodes
, Journal of Physical Chemistry Letters 11(12): 4649-4654 (2020 )

Design of the Internet plus Drug Circulation Business Model Based on Value Chain
, Journal of Healthcare Engineering 2021: 6673649 (2021)

Design of the Japanese Comprehensive Health-Economic Assessment for Appropriate Cardiac Imaging Strategy Including Outcome and Cost-Effectiveness in Stable Coronary Artery Disease Study (J-CONCIOUS)
, Circulation Reports 2(12): 759-763 (2020)

Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach
, Kidney International 83(4): 749-756 (2013)

Design of the PROstate cancer follow-up care in Secondary and Primary hEalth Care study (PROSPEC): a randomized controlled trial to evaluate the effectiveness of primary care-based follow-up of localized prostate cancer survivors
, Bmc Cancer 20(1): 635 (2020)

Design of the Pregnancy REmote MOnitoring II study (PREMOM II): a multicenter, randomized controlled trial of remote monitoring for gestational hypertensive disorders
, Bmc Pregnancy and Childbirth 20(1): 626 (2020)

Design of the Recombinant Influenza Neuraminidase Antigen is Crucial for its Biochemical Properties and Protective Efficacy
, Journal of Virology 2021: Jvi0116021 (2021)

Design of the Redefining Therapy in Early COPD Study
, Chronic Obstructive Pulmonary Diseases 7(4): 382-389 (2020)

Design of the Shunyi study on cardiovascular disease and age-related brain changes: a community-based, prospective, cohort study
, Annals of Translational Medicine 8(23): 1579 (2020)

Design of the Spine Pain Intervention to Enhance Care Quality And Reduce Expenditure Trial (SPINE CARE) study: Methods and lessons from a multi-site pragmatic cluster randomized controlled trial
, Contemporary Clinical Trials 2021: 106602 (2021)

Design of the bronchial tree
, Nature 213(5077): 668-669 (1967)

Design of the healthcare worker exposure response and outcomes (HERO) research platform
, Contemporary Clinical Trials 2021: 106525 (2021)

Design of the limits of tuberculosis disease; prophylactic deductions
, Revue de Pathologie Comparee 46: 85-97 (1946)

Design of the persistent luminescence colour of a novel Gd 3-x Tb x Ga 3 Al 2 O 12 phosphor: synthesis methods, spectroscopic properties and mechanism
, Dalton Transactions 50(14): 4830-4839 (2021)

Design of the pilot, proof of concept REMOTE-COVID trial: remote monitoring use in suspected cases of COVID-19 (SARS-CoV-2)
, Pilot and Feasibility Studies 7(1): 62 (2021)

Design of the reticulohistiocytic system; the regulation of the hystiocytic state and the cell specificity
, Revue d'Hematologie 4(4): 639-654 (1949)

Design of the tundra rainfall experiment (TRainEx) to simulate future summer precipitation scenarios
, Methodsx 8: 101331 (2021)

Design of thermolabile bacteriophage repressor mutants by comparative molecular modeling
, Nature Biotechnology 15(10): 980-983 (1997)

Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets
, Scientific Reports 10(1): 12027 (2020)

Design of thiol-lithium ion interaction in metal-organic framework for high-performance quasi-solid lithium metal batteries
, Dalton Transactions 50(8): 2928-2935 (2021)

Design of three-dimensional foraminal guide device and application in percutaneous endoscopic lumbar discectomy
, Zhongguo Gu Shang 33(10): 943-947 (2020)

Design of time-delayed safety switches for CRISPR gene therapy
, Scientific Reports 11(1): 16908 (2021)

Design of tissue-specific regulatory cassettes for high-level rAAV-mediated expression in skeletal and cardiac muscle
, Molecular Therapy: the Journal of the American Society of Gene Therapy 15(2): 320-329 (2007)

Design of tough adhesive from commodity thermoplastics through dynamic crosslinking
, Science Advances 7(42): Eabk2451 (2021)

Design of training populations for selective phenotyping in genomic prediction
, Scientific Reports 9(1): 1446 (2019)

Design of tunable gelatin-dopamine based bioadhesives
, International Journal of Biological Macromolecules 164: 1384-1391 (2020)

Design of two compact waveguide display systems utilizing metasurface gratings as couplers
, Applied Optics 60(28): 8756-8765 (2021)

Design of two invisibility cloaks using transmissive and reflective metamaterial-based multilayer frame microstructures
, Optics Express 28(24): 35528-35539 (2020)

Design of ultra-broadband absorption enhancement in plasmonic absorber by interaction resonance of multi-plasmon modes and Fabry-Perot mode
, Optics Express 29(18): 29228-29241 (2021)

Design of ultra-fine carvedilol nanococrystals: Development of a safe and stable injectable formulation
, European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 2021 (2021)

Design of ultra-high luminescent polymers for organic photovoltaic cells with low energy loss
, Chemical Communications 57(72): 9132-9135 (2021)

Design of ultra-small mode area all-dielectric waveguides exploiting the vectorial nature of light
, Optics Letters 45(17): 4730-4733 (2020)

Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains
, Nature Communications 9(1): 544 (2018)

Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression
, Acta Pharmaceutica Sinica. B 11(9): 2655-2669 (2021)

Design of ultrasensitive Ag-LaFeO 3 methanol gas sensor based on quasi molecular imprinting technology
, Scientific Reports 8(1): 14220 (2018)

Design of ultrasonic standing wave levitation support for three-dimensional printed filaments
, Journal of the Acoustical Society of America 149(4): 2848 (2021)

Design of ultrathin nanosheet subunits ZnIn 2 S 4 hollow nanocages with enhanced photoelectric conversion for ultrasensitive photoelectrochemical sensing
, Biosensors and Bioelectronics 2020: 112873 (2020)

Design of uniform permanent magnet electronic optical system for 220 GHz sheet electron beam traveling wave tube
, Scientific Reports 10(1): 13680 (2020)

Design of van der Waals interfaces for broad-spectrum optoelectronics
, Nature Materials 19(3): 299-304 (2020)

Design of zeolite by inverse sigma transformation
, Nature Materials 11(12): 1059-1064 (2012)

Design of zoom systems composed of lenses with variable focal length
, Applied Optics 59(34): 10838-10845 (2020)

Design of α-Fe2O3 nanorods functionalized tubular NiO nanostructure for discriminating toluene molecules
, Scientific Reports 6: 26432 (2016)

Design of γ-AlOOH, γ-MnOOH, and α-Mn 2 O 3 nanorods as advanced antibacterial active agents
, Dalton Transactions 49(25): 8601-8613 (2020)

Design optimization and characterization of Her2/neu-targeted immunotoxins: comparative in vitro and in vivo efficacy studies
, Oncogene 33(4): 429-439 (2014)

Design optimization for bright electrically-driven quantum dot single-photon sources emitting in telecom O-band
, Optics Express 29(5): 6582-6598 (2021)

Design optimization of a 6.4 mm-diameter electromagnetic 2D scanning micromirror
, Optics Express 28(21): 31272-31286 (2020)

Design optimization of bidirectional arterial perfusion cannula
, Journal of Cardiothoracic Surgery 16(1): 114 (2021)

Design optimization of implant geometrical characteristics enhancing primary stability using FEA of stress distribution around dental prosthesis
, Computer Methods in Biomechanics and Biomedical Engineering 2021: 1-17 (2021)

Design optimization of orbital angular momentum fibers using the gray wolf optimizer
, Applied Optics 59(20): 6181-6190 (2020)

Design principle for increasing charge mobility of π-conjugated polymers using regularly localized molecular orbitals
, Nature Communications 4: 1691 (2013)

Design principles for electronic charge transport in solution-processed vertically stacked 2D perovskite quantum wells
, Nature Communications 9(1): 2130 (2018)

Design principles for enhancing phase sensitivity and suppressing phase fluctuations simultaneously in biochemical oscillatory systems
, Nature Communications 9(1): 1434 (2018)

Design principles for maximizing photovoltage in metal-oxide-protected water-splitting photoanodes
, Nature Materials 15(1): 99-105 (2016)

Design principles for non-reciprocal photomechanical actuation
, Soft Matter 16(25): 5951-5958 (2020)

Design principles for oxygen-reduction activity on perovskite oxide catalysts for fuel cells and metal-air batteries
, Nature Chemistry 3(7): 546-550 (2011)

Design principles for rapid folding of knotted DNA nanostructures
, Nature Communications 7: 10803 (2016)

Design principles for self-forming interfaces enabling stable lithium-metal anodes
, Proceedings of the National Academy of Sciences of the United States of America 117(44): 27195-27203 (2020)

Design principles for shift current photovoltaics
, Nature Communications 8: 14176 (2017)

Design principles for single standing nanowire solar cells: going beyond the planar efficiency limits
, Scientific Reports 4: 4915 (2014)

Design principles for solid-state lithium superionic conductors
, Nature Materials 14(10): 1026-1031 (2015)

Design principles for the glycoprotein quality control pathway
, Plos Computational Biology 17(2): E1008654 (2021)

Design principles governing chemomechanical coupling of kinesin
, Scientific Reports 7(1): 1163 (2017)

Design principles of a bacterial signalling network
, Nature 438(7067): 504-507 (2005)

Design principles of a minimal auxin response system
, Nature Plants 6(5): 473-482 (2020)

Design principles of adaptive immune systems
, Nature Reviews. Immunology 11(5): 307-317 (2011)

Design principles of biochemical oscillators
, Nature Reviews. Molecular Cell Biology 9(12): 981-991 (2008)

Design principles of biologically fabricated avian nests
, Scientific Reports 9(1): 4792 (2019)

Design principles of chiral carbon nanodots help convey chirality from molecular to nanoscale level
, Nature Communications 9(1): 3442 (2018)

Design principles of collateral sensitivity-based dosing strategies
, Nature Communications 12(1): 5691 (2021)

Design principles of gene evolution for niche adaptation through changes in protein-protein interaction networks
, Scientific Reports 10(1): 15628 (2020)

Design principles of ion selective nanostructured membranes for the extraction of lithium ions
, Nature Communications 10(1): 5793 (2019)

Design principles of nuclear receptor signaling: how complex networking improves signal transduction
, Molecular Systems Biology 6: 446 (2010)

Design principles of oil-in-water emulsions with functionalized interfaces: Mixed, multilayer, and covalent complex structures
, Comprehensive Reviews in Food Science and Food Safety 19(6): 3159-3190 (2020)

Design principles of protein switches
, Current Opinion in Structural Biology 72: 71-78 (2021)

Design principles of tissue organisation: How single cells coordinate across scales
, Current Opinion in Cell Biology 67: 37-45 (2020)

Design principles, synthesis and biomedical applications of polymer vesicles with inhomogeneous membranes
, Journal of Controlled Release: Official Journal of the Controlled Release Society 326: 365-386 (2020)

Design procedure for triply periodic minimal surface based biomimetic scaffolds
, Journal of the Mechanical Behavior of Biomedical Materials 2021: 104871 (2021)

Design process and protocol description for a multi-problem mental health intervention within a stepped care approach for adolescents in India
, Behaviour Research and Therapy 133: 103698 (2020)

Design recommendations for exoskeletons: Perspectives of individuals with spinal cord injury
, Journal of Spinal Cord Medicine 2021: 1-6 (2021)

Design routine and characterisation of a biconic deformable metal mirror for focus shifting
, Optics Express 29(3): 2971-2983 (2021)

Design rules for a tunable merged-tip microneedle
, Microsystems and Nanoengineering 4: 29 (2018)

Design rules for dense and rapid Lissajous scanning
, Microsystems and Nanoengineering 6: 101 (2020)

Design rules for light-emitting electrochemical cells delivering bright luminance at 27.5 percent external quantum efficiency
, Nature Communications 8(1): 1190 (2017)

Design rules for liquid crystalline electrolytes for enabling dendrite-free lithium metal batteries
, Proceedings of the National Academy of Sciences of the United States of America 117(43): 26672-26680 (2020)

Design rules for minimizing voltage losses in high-efficiency organic solar cells
, Nature Materials 17(8): 703-709 (2018)

Design rules for scalability in spin-orbit electronics
, Scientific Reports 9(1): 13732 (2019)

Design rules for self-assembled block copolymer patterns using tiled templates
, Nature Communications 5: 3305 (2014)

Design simulations of a horizontally deflecting high-heat-load monochromator
, Journal of Synchrotron Radiation 28(Pt 1): 91-103 (2021)

Design strategies and evolving role of biomaterial assisted treatment of osteosarcoma
, Materials Science and Engineering. C Materials for Biological Applications 121: 111875 (2021)

Design strategies for long-acting anti-HIV pharmaceuticals
, Current Opinion in Pharmacology 54: 158-165 (2020)

Design strategies for organic semiconductors beyond the molecular formula
, Nature Chemistry 4(9): 699-704 (2012)

Design strategy and interface chemistry of ageing stable AZO films as high quality transparent conducting oxide
, Journal of Colloid and Interface Science 582(Pt B): 1041-1057 (2021)

Design strategy for assessing multi-pathway exposure for children: the Minnesota Children's Pesticide Exposure Study (MNCPES)
, Journal of Exposure Analysis and Environmental Epidemiology 10(2): 145-158 (2000)

Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
, Nature Communications 10(1): 876 (2019)

Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high-anticoagulant thrombin-binding bivalent DNA aptamer-linked M08 with HD22
, Research and Practice in Thrombosis and Haemostasis 5(5): E12503 (2021)

Design study of a compact ultra-wide-angle high-spatial-resolution high-spectral-resolution snapshot imaging spectrometer
, Optics Express 29(2): 2893-2908 (2021)

Design study of a dedicated head and neck cancer PET system
, IEEE Transactions on Radiation and Plasma Medical Sciences 4(4): 489-497 (2020)

Design synthesis and evaluation of novel aldose reductase inhibitors: The case of indolyl-sulfonyl-phenols
, Bioorganic and Medicinal Chemistry 28(15): 115575 (2020)

Design the RNA aptamer of PCA3 long non-coding ribonucleic acid by the coarse-grained molecular mechanics
, Journal of Biomolecular Structure and Dynamics 2021: 1-15 (2021)

Design thinking in applied informatics: what can we learn from Project Health Design?
, Journal of the American Medical Informatics Association: Jamia 2021 (2021)

Design versus research in BME accreditation
, IEEE Engineering in Medicine and Biology Magazine: the Quarterly Magazine of the Engineering in Medicine and Biology Society 27(2): 80-85 (2008)

Design, Bioactivity and structure-activity of 3-Arylpropionate Derivatives as Potential High-Efficient Acaricides against Psoroptes Cuniculi
, Scientific Reports 8(1): 1797 (2018)

Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels
, Frontiers in Medicine 7: 456 (2020)

Design, Characterization, and Analysis of PZT Micromachined Piezoelectric Ultrasonic Transducers With Good Coupling to Solids
, IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 67(10): 2135-2141 (2020)

Design, Characterization, and Application of a pH-Triggered In Situ Gel for Ocular Delivery of Vinpocetine
, Aaps Pharmscitech 21(7): 253 (2020)

Design, Construction and Immunogenicity Assessment of pEGFP-N1-KMP11-GP96 (Fusion) as a DNA Vaccine Candidate against Leishmania major Infection in BALB/c Mice
, Iranian Journal of Parasitology 15(1): 11-21 (2020)

Design, Construction and Validation of an Electrical Impedance Probe with Contact Force and Temperature Sensors Suitable for in-vivo Measurements
, Scientific Reports 8(1): 14818 (2018)

Design, Control, and Simulation of a Neonatal Incubator
, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2020: 6018-6023 (2020)

Design, DFT studies, antimicrobial and antioxidant potential of Binuclear N-heterocyclic Carbene (NHCs) complexes, Probing the aspect of DNA interaction through In-vitro and In-silico approach
, Computational Biology and Chemistry 2021: 107591 (2021)

Design, Development and Optimization of a Functional Mammalian Cell-Free Protein Synthesis Platform
, Frontiers in Bioengineering and Biotechnology 8: 604091 (2020)

Design, Development, and Evaluation of a Telemedicine Platform for Patients With Sleep Apnea (Ognomy): Design Science Research Approach
, Jmir Formative Research 5(7): E26059 (2021)

Design, Evolution, and Characterization of a Xylose Biosensor in Escherichia coli Using the XylR/ xylO System with an Expanded Operating Range
, Acs Synthetic Biology 9(10): 2714-2722 (2020)

Design, Expression and Purification of Strongyloides stercoralis IgG4 Immunoreactive Protein (NIE) in Escherichia coli
, Iranian Journal of Parasitology 15(3): 341-348 (2020)

Design, Expression, Purification, and Characterization of a YFP-Tagged 2019-nCoV Spike Receptor-Binding Domain Construct
, Frontiers in Bioengineering and Biotechnology 8: 618615 (2020)

Design, Fabrication and Applications of Electrospun Nanofiber-Based Surface-Enhanced Raman Spectroscopy Substrate
, Critical Reviews in Analytical Chemistry 2021: 1-20 (2021)

Design, Fabrication, and Analysis of a Capillary Diode for Potential Application in Water-Oil Separation
, Acs Applied Materials and Interfaces 12(41): 45950-45960 (2020)

Design, Fabrication, and In Vitro Evaluation of Nanoceria-Loaded Nanostructured Lipid Carriers for the Treatment of Neurological Diseases
, Acs Biomaterials Science and Engineering 5(2): 670-682 (2019)

Design, Fabrication, and Mechanism of Nitrogen-Doped Graphene-Based Photocatalyst
, Advanced Materials 2021: E2003521 (2021)

Design, Fabrication, and Testing of a Novel Surgical Handwashing Machine
, Surgical Innovation 2020: 1553350620958241 (2020)

Design, Fabrication, and Validation of a Polymethyl Methacrylate Head Phantom for Dosimetric Verification of Cranial Radiotherapy Treatment Plans
, Journal of Medical Physics 45(2): 66-70 (2020)

Design, Formulation and In Vitro Evaluation of Sustained-release Tablet Formulations of Levosulpiride
, Turkish Journal of Pharmaceutical Sciences 15(3): 309-318 (2018)

Design, Formulation and Physicochemical Evaluation of Dimenhydrinate Orally Disintegrating Tablets
, Galen Medical Journal 7: E936 (2018)

Design, Hemiysnthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol
, Bioorganic Chemistry 115: 105165 (2021)

Design, Implementation, and Evaluation of Compliance With Pharmacy Workflow During a Pediatric Oncology Computerized Provider Order Entry (CPOE) Launch
, Journal of Pediatric Pharmacology and Therapeutics: Jppt: the Official Journal of Ppag 26(5): 491-496 (2021)

Design, Implementation, and Evaluation of a Distance Learning Framework to Adapt to the Changing Landscape of Anatomy Instruction in Medical Education During COVID-19 Pandemic: A Proof-of-Concept Study
, Frontiers in Public Health 9: 726814 (2021)

Design, Implementation, and Examination of a Remote Patient Monitoring System for Pediatric Obesity: Protocol for an Open Trial Pilot Study
, Jmir Research Protocols 10(7): E29858 (2021)

Design, Implementation, and Validation of a Pulsatile Heart Phantom Pump
, Journal of Digital Imaging 33(5): 1301-1305 (2020)

Design, Microstructure and Mechanical Properties of Cast Medium Entropy Aluminium Alloys
, Scientific Reports 9(1): 6792 (2019)

Design, Modeling, Control, and Application of Everting Vine Robots
, Frontiers in Robotics and Ai 7: 548266 (2020)

Design, Preparation and evaluation of various parameters of controlled release matrices of losartan potassium using polymers combination
, Pakistan Journal of Pharmaceutical Sciences 33(5(Supplementary): 2231-2237 (2020)

Design, Preparation, and Bioactivity Study of New Fusion Protein HB-NC4 in the Treatment of Osteoarthritis
, Frontiers in Bioengineering and Biotechnology 9: 700064 (2021)

Design, Recruitment, and Baseline Characteristics of a Virtual 1-Year Mental Health Study on Behavioral Data and Health Outcomes: Observational Study
, Jmir Mental Health 7(7): E17075 (2020)

Design, Simulation, and Development of a BioSensor for Viruses Detection Using FPGA
, IEEE Journal of Translational Engineering in Health and Medicine 9: 1700106 (2021)

Design, Simulation, and Environmental Assessment of an Adsorption-Based Treatment Process for the Removal of Polycyclic Aromatic Hydrocarbons (PAHs) from Seawater and Sediments in North Colombia
, Acs Omega 5(21): 12126-12135 (2020)

Design, Synthesis And In-vitro Evaluation Of Fluorinated Triazoles as Multi-Target Directed Ligands for Alzheimer Disease
, Bioorganic and Medicinal Chemistry Letters 2021: 127999 (2021)

Design, Synthesis and Activity Evaluation of New Phthalazinone PARP Inhibitors
, Chemical and Pharmaceutical Bulletin 69(7): 620-629 (2021)

Design, synthesis and analysis of novel sphingosine kinase-1 inhibitors to improve oral bioavailability
, Bioorganic and Medicinal Chemistry Letters 2021: 128329 (2021)

Design, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles
, Bioorganic and Medicinal Chemistry Letters 2021: 128307 (2021)

Design, Synthesis and Antifungal Activities of 6-Substituted 3-Butylphthalide Derivatives against Phytopathogenic Fungi
, Chemistry and Biodiversity 17(10): E2000435 (2020)

Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents
, Scientific Reports 6: 25387 (2016)

Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines
, Bioorganic and Medicinal Chemistry Letters 2021: 127987 (2021)

Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits
, Chemistryopen 10(9): 896-903 (2021)

Design, Synthesis and Biological Evaluation of 2-Aminoquinazolin-4(3H)-one Derivatives as Potential SARS-CoV-2 and MERS-CoV Treatments
, Bioorganic and Medicinal Chemistry Letters 2021: 127885 (2021)

Design, Synthesis and Biological Evaluation of 5-amino-3-aryl-1-(6'-chloropyridazin-3'-yl)pyrazoles and their Derivatives as Analgesic Agents
, Drug Research 70(11): 493-502 (2020)

Design, Synthesis and Biological Evaluation of New Thiazole Scaffolds as Potential TRPM8 Antagonists
, Bioorganic and Medicinal Chemistry Letters 2021: 128392 ( 2021)

Design, Synthesis and Biological Evaluation of Novel 4-(4-Methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines as Tubulin Polymerization Inhibitors
, Chemical and Pharmaceutical Bulletin 68(12): 1184-1192 (2020)

Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents
, Advanced Pharmaceutical Bulletin 10(3): 423-429 (2020)

Design, Synthesis and Biological Evaluation of Novel Pyrazole Sulfonamide Derivatives as Potential AHAS Inhibitors
, Chemical and Pharmaceutical Bulletin 66(4): 358-362 (2018)

Design, Synthesis and Biological Evaluation of Xanthone Derivatives for Possible Treatment of Alzheimer's Disease Based on Multi-Target Strategy
, Chemistry and Biodiversity 17(10): E2000442 (2020)

Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer
, Scientific Reports 7(1): 1665 (2017)

Design, Synthesis and Biological Evaluation of the Quinazoline Derivatives as L858R/T790M/C797S Triple Mutant Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
, Chemical and Pharmaceutical Bulletin 68(10): 971-980 (2020)

Design, Synthesis and Biological Screening of Novel 1,5-Diphenyl-3-(4-(trifluoromethyl)phenyl)-2-pyrazoline Derivatives
, Acta Chimica Slovenica 67(4): 1139-1147 (2020)

Design, Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives Containing Benzoic Acid Group as Potential AKR1C3 Inhibitors
, Chemistry and Biodiversity 17(12): E2000519 (2020)

Design, Synthesis and Evaluation of 2,4-Diaminoquinazoline Derivatives as Potential Tubulin Polymerization Inhibitors
, Chemmedchem 15(19): 1802-1812 (2020)

Design, Synthesis and Evaluation of Novel Isoxazolines/Oxime Sulfonates of 2'(2',6')-(Di)Chloropodophyllotoxins as Insecticidal Agents
, Scientific Reports 6: 33062 (2016)

Design, Synthesis and Evaluation of the Biological Activities of Some New Carbohydrazide and Urea Derivatives
, Turkish Journal of Pharmaceutical Sciences 15(3): 304-308 (2018)

Design, Synthesis and In Vitro Cytotoxic Activity of New 6,9-Disubstituted Purine Analogues
, Acta Chimica Slovenica 67(1): 70-82 (2020)

Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors
, Scientific Reports 5: 9769 (2015)

Design, Synthesis and Pharmacological Evaluation of Naphthofuran Derivatives as Potent SIRT1 Activators
, Frontiers in Pharmacology 12: 653233 (2021)

Design, Synthesis and Pharmacological Evaluation of Some C 3 Heterocyclic-Substituted Ciprofloxacin Derivatives as Chimeric Antitubercular Agents
, Chemical and Pharmaceutical Bulletin 68(12): 1170-1177 (2020)

Design, Synthesis and Structure-Activity Relationship Optimization of Lycorine Derivatives for HCV Inhibition
, Scientific Reports 5: 14972 (2015)

Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D
, European Journal of Medicinal Chemistry 214: 113226 (2021)

Design, Synthesis and in Vitro Evaluation of Tylophorine Derivatives as Possible Antitumor Agents
, Chemistry and Biodiversity 17(9): E2000066 (2020)

Design, Synthesis, Anticancer Evaluation, Enzymatic Assays, and a Molecular Modeling Study of Novel Pyrazole-Indole Hybrids
, Acs Omega 6(18): 12361-12374 (2021)

Design, Synthesis, Antiproliferative Evaluation, and Molecular Docking Studies of N -(3-Hydroxyindole)-Appended β-Carbolines/Tetrahydro-β-Carbolines Targeting Triple-Negative and Non-Triple-Negative Breast Cancer
, Acs Omega 5(45): 28907-28917 (2020)

Design, Synthesis, Antiviral Bioactivity, and Mechanism of the Ferulic Acid Ester-Containing Sulfonamide Moiety
, Acs Omega 5(31): 19721-19726 (2020)

Design, Synthesis, Biological Evaluation and Molecular Docking Studies of Some New Sulfonamides Possessing 1,4-Benzodioxane Nucleus
, Acta Chimica Slovenica 66(2): 294-307 (2019)

Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives
, Drug Design Development and Therapy 15: 3119-3129 (2021)

Design, Synthesis, Characterization, and Crystal Structure Studies of Nrf2 Modulators for Inhibiting Cancer Cell Growth In Vitro and In Vivo
, Acs Omega 6(15): 10054-10071 (2021)

Design, Synthesis, Conjugation, and Reactivity of Novel trans,trans -1,5-Cyclooctadiene-Derived Bioorthogonal Linkers
, Bioconjugate Chemistry 31(9): 2201-2210 (2020)

Design, Synthesis, Molecular Docking, and Biological Evaluation of New Emodin Anthraquinone Derivatives as Potential Antitumor Substances
, Chemistry and Biodiversity 17(9): E2000328 (2020)

Design, Synthesis, Molecular Modeling Study and Biological Evaluation of New N'-Arylidene-pyrido [2,3- d ]pyrimidine-5-carbohydrazide Derivatives as Anti-HIV-1 Agents
, Iranian Journal of Pharmaceutical Research: Ijpr 18(Suppl1): 237-248 (2019)

Design, Synthesis, Molecular Modeling, Anticancer Studies, and Density Functional Theory Calculations of 4-(1,2,4-Triazol-3-ylsulfanylmethyl)-1,2,3-triazole Derivatives
, Acs Omega 6(1): 301-316 (2021)

Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents
, Drug Design Development and Therapy 15: 385-397 (2021)

Design, Synthesis, Pharmacokinetics, and Biodistribution of a Series of Bone-Targeting EP4 Receptor Agonist Prodrugs for Treatment of Osteoporosis and Other Bone Conditions
, Acs Pharmacology and Translational Science 4(2): 908-925 (2021)

Design, Synthesis, Spectral and Theoretical Study of New Bile Acid-Sterol Conjugates Linked via 1,2,3-Triazole Ring
, Steroids 2021: 108934 (2021)

Design, Synthesis, and Activity Study of Water-Soluble, Rapid-Release Propofol Prodrugs
, Journal of Medicinal Chemistry 63(14): 7857-7866 (2020)

Design, synthesis, and antibacterial evaluation of vancomycin-LPS binding peptide conjugates
, Bioorganic and Medicinal Chemistry Letters 2021: 128122 (2021)

Design, Synthesis, and Anticancer Activity Evaluation of Hybrids of Azoles and Barbituric Acids
, Iranian Journal of Pharmaceutical Research: Ijpr 20(2): 144-155 (2021)

Design, Synthesis, and Antifungal Activity of Novel Longifolene-Derived Diacylhydrazine Compounds
, Acs Omega 6(13): 9104-9111 (2021)

Design, Synthesis, and Antimicrobial Evaluation of a New Series of N -Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes
, Acs Omega 5(18): 10401-10414 (2020)

Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides
, Frontiers in Chemistry 8: 616147 (2020)

Design, Synthesis, and Application of a Small Molecular NIR-II Fluorophore with Maximal Emission beyond 1200 nm
, Journal of the American Chemical Society 142(36): 15271-15275 (2020)

Design, Synthesis, and Biological Activity Studies of Istradefylline Derivatives Based on Adenine as A 2A Receptor Antagonists
, Acs Omega 6(6): 4386-4394 (2021)

Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin
, Acs Omega 5(36): 23164-23174 (2020)

Design, Synthesis, and Biological Activity of Novel Ferulic Amide Ac5c Derivatives
, Acs Omega 6(41): 27561-27567 (2021)

Design, Synthesis, and Biological Evaluation of 1,2,4-Thiadiazole-1,2,4-Triazole Derivatives Bearing Amide Functionality as Anticancer Agents
, Arabian Journal for Science and Engineering 2020: 1-8 (2020)

Design, synthesis, and biological evaluation of 1,3,6,7-tetrahydroxyxanthone derivatives as phosphoglycerate mutase 1 inhibitors
, Bioorganic and Medicinal Chemistry Letters 2021: 127820 (2021)

Design, Synthesis, and Biological Evaluation of Benzo[cd]indol-2(1H)-ones Derivatives as a Lysosome-Targeted Anti-metastatic Agent
, Frontiers in Oncology 11: 733589 (2021)

Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma
, Journal of Medicinal Chemistry 63(21): 12707-12724 (2020)

Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs
, Acs Medicinal Chemistry Letters 12(1): 82-87 (2021)

Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists
, Acs Medicinal Chemistry Letters 12(5): 768-773 (2021)

Design, Synthesis, and Biological Evaluation of Novel 1,3-Oxazole Sulfonamides as Tubulin Polymerization Inhibitors
, Acs Medicinal Chemistry Letters 12(6): 1030-1037 (2021)

Design, Synthesis, and Biological Evaluation of Novel 7 H -[1,2,4]Triazolo[3,4- b ][1,3,4]thiadiazine Inhibitors as Antitumor Agents
, Acs Omega 5(32): 20170-20186 (2020)

Design, Synthesis, and Biological Evaluation of Novel Acylhydrazone Derivatives as Potent Neuraminidase Inhibitors
, Acs Medicinal Chemistry Letters 11(9): 1745-1750 (2020)

Design, Synthesis, and Biological Evaluation of Novel Multifunctional Rolipram-Tranilast Hybrids As Potential Treatment for Traumatic Brain Injury
, Acs Chemical Neuroscience 11(15): 2348-2360 (2020)

Design, Synthesis, and Biological Evaluation of Novel Thiazolidinone-Containing Quinoxaline-1,4-di- N -oxides as Antimycobacterial and Antifungal Agents
, Frontiers in Chemistry 8: 598 (2020)

Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of 3-Hydroxymorphinan
, Scientific Reports 9(1): 2247 (2019)

Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector
, Oxidative Medicine and Cellular Longevity 2021: 4714649 (2021)

Design, Synthesis, and Biophysical Evaluation of Mechanism-Based Probes for Condensation Domains of Nonribosomal Peptide Synthetases
, Acs Chemical Biology 15(7): 1813-1819 (2020)

Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2
, Journal of Medicinal Chemistry 63(20): 12060-12072 ( 2020)

Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer
, Journal of Medicinal Chemistry 63(23): 14609-14625 (2020)

Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs
, Acs Medicinal Chemistry Letters 11(10): 1855-1862 (2020)

Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors
, Journal of Medicinal Chemistry 63(17): 9752-9772 (2020)

Design, Synthesis, and Evaluation of Novel Modular Bisubstrate Analogue Inhibitors of Farnesyltransferase
, Angewandte Chemie 38(13-14): 2032-2034 (1999)

Design, Synthesis, and Evaluation of a Series of Novel Super Long-Acting DPP-4 Inhibitors for the Treatment of Type 2 Diabetes
, Journal of Medicinal Chemistry 63(13): 7108-7126 (2020)

Design, Synthesis, and Functional Evaluation of a Novel Series of Phosphonate-Functionalized 1,2,3-Triazoles as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors
, Acs Chemical Neuroscience 11(17): 2688-2704 (2020)

Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Fluconazole-Based Compounds with Promising Antifungal Activities
, Acs Omega 6(38): 24981-25001 (2021)

Design, Synthesis, and Monoamine Oxidase Inhibitory Activity of (+)-Cinchonaminone and Its Simplified Derivatives
, Acs Medicinal Chemistry Letters 12(9): 1464-1469 (2021)

Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT 2A /mGlu 2 Receptor Complex
, Journal of Medicinal Chemistry 63(17): 9928-9949 (2020)

Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics
, Journal of Medicinal Chemistry 63(21): 12574-12594 (2020)

Design, Synthesis, and Pharmacological Evaluation of Analogues Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6
, Journal of Medicinal Chemistry 63(20): 11522-11547 (2020)

Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time
, Acs Medicinal Chemistry Letters 11(6): 1205-1212 (2020)

Design, Synthesis, and Photocatalytic Application of Moisture-Stable Hybrid Lead-Free Perovskite
, Acs Applied Materials and Interfaces 12(49): 54694-54702 (2020)

Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3- b ]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo
, Journal of Medicinal Chemistry 63(13): 7369-7391 (2020)

Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5- b ]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders
, Journal of Medicinal Chemistry 63(17): 9181-9196 (2020)

Design, Synthesis, and Preliminary Immunological Studies of MUC1-Based Antitumor Vaccines Adjuvanted with R - and S -FSL-1
, Acs Medicinal Chemistry Letters 11(7): 1371-1376 (2020)

Design, Synthesis, and Resolution of Spirocyclic Bisoxindole-Based C 2 -Symmetric Diols
, Journal of Organic Chemistry 85(16): 10584-10592 (2020)

Design, Synthesis, and Self-Assembly of Janus Bottlebrush Polymers
, Macromolecular Rapid Communications 41(20): E2000357 (2020)

Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists
, Journal of Medicinal Chemistry 63(23): 14989-15012 (2020)

Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase
, Journal of Medicinal Chemistry 63(20): 11498-11521 (2020)

Design, Synthesis, and Structure-Activity Relationships Study of N-Pyrimidyl/Pyridyl-2-thiazolamine Analogues as Novel Positive Allosteric Modulators of M 3 Muscarinic Acetylcholine Receptor
, Chemical and Pharmaceutical Bulletin 69(4): 360-373 (2021)

Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors
, Journal of Medicinal Chemistry 63(19): 11149-11168 (2020)

Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates
, Journal of Medicinal Chemistry 63(22): 13913-13950 (2020)

Design, Synthesis, and Temperature-Driven Molecular Conformation-Dependent Delayed Fluorescence Characteristics of Dianthrylboron-Based Donor-Acceptor Systems
, Frontiers in Chemistry 8: 541331 (2020)

Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities
, Acs Medicinal Chemistry Letters 11(10): 1965-1972 (2020)

Design, synthesis, and biological evaluation of 2,6,7-substituted pyrrolo[2,3-d]pyrimidines as cyclin dependent kinase inhibitor in pancreatic cancer cells
, Bioorganic and Medicinal Chemistry Letters 2020: 127725 (2020)

Design, Synthesis, and the Effects of ( E )-9-Oxooctadec-10-en-12-ynoic Acid Analogues to Promote Glucose Uptake
, Acs Omega 6(37): 24118-24127 ( 2021)

Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo[3,4-d]Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell apoptosis inducers
, Bioorganic Chemistry 116: 105325 (2021)

Design, Use, and Effects of Sex Dolls and Sex Robots: Scoping Review
, Journal of Medical Internet Research 22(7): E18551 (2020)

Design, Validation, and Reliability of an Observational Instrument for Technical and Tactical Actions in Singles Badminton
, Frontiers in Psychology 11: 582693 (2020)

Design, alignment, and calibration of a focused laser differential interferometer
, Applied Optics 60(26): 7903-7909 (2021)

Design, application, and evaluation of a novel method for determining optimal trajectory of thoracic pedicle screws
, Annals of Translational Medicine 8(16): 1012 (2020)

Design, application, and microbiome of sulfate-reducing bioreactors for treatment of mining-influenced water
, Applied Microbiology and Biotechnology 104(16): 6893-6903 (2020)

Design, assembly and validation of a low-cost, high-fidelity simulator for heart exploration
, Gaceta Medica de Mexico 157(1): 24-28 (2021)

Design, assembly, characterization, and operation of double-stranded interlocked DNA nanostructures
, Nature Protocols 14(10): 2818-2855 (2019)

Design, biological activity and NMR-solution structure of a DNA analogue of yeast tRNA(Phe) anticodon domain
, Nature Structural Biology 3(1): 38-44 (1996)

Design, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors
, Scientific Reports 6: 27571 (2016)

Design, calibration and application of broad-range optical nanosensors for determining intracellular pH
, Nature Protocols 9(12): 2841-2858 (2014)

Design, challenges, and the potential of transcriptomics to understand social behavior
, Current Zoology 66(3): 321-330 (2020)

Design, characterisation and drug release study of polymeric, drug-eluting single layer thin films on the surface of intraocular lenses
, Iet Nanobiotechnology 14(6): 501-507 (2020)

Design, characterization and anti-tumour cytotoxicity of a panel of recombinant, mammalian ribonuclease-based immunotoxins
, British Journal of Cancer 77(4): 537-546 (1998)

Design, characterization and in vitro evaluation of thin films enriched by tannic acid complexed by Fe(III) ions
, Progress in Biomaterials 9(4): 249-257 (2020)

Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends
, Scientific Reports 8(1): 7417 (2018)

Design, characterization, and adsorption properties of Padina gymnospora/zeolite nanocomposite for Congo red dye removal from wastewater
, Scientific Reports 11(1): 21058 (2021)

Design, characterization, and fabrication of 90-degree viewing angle catadioptric retroreflector floating device using in 3D floating light-field display system
, Optics Express 28(17): 24854-24873 (2020)

Design, characterization, and modeling of a chitosan microneedle patch for transdermal delivery of meloxicam as a pain management strategy for use in cattle
, Materials Science and Engineering. C Materials for Biological Applications 118: 111544 (2021)

Design, conduct, and analysis of clinical trials in disease due to methicillin-resistant Staphylococcus aureus
, Clinical Pharmacology and Therapeutics 86(3): 244-247 (2009)

Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis
, Scientific Reports 9(1): 12944 (2019)

Design, construction and characterisation of a portable gamma-ray spectrometer for low-level natural occurring radioactive material ex-situ measurement
, Journal of Environmental Radioactivity 225: 106415 (2020)

Design, construction and in vitro testing of zinc finger nucleases
, Nature Protocols 1(3): 1329-1341 (2006)

Design, construction, and expression of recombinant human interferon beta gene in CHO-s cell line using EBV-based expression system
, Research in Pharmaceutical Sciences 15(2): 144-153 (2020)

Design, construction, and testing of an accurate low-cost humidistat for laboratory-scale applications
, European Physical Journal. E Soft Matter 44(4): 48 (2021)

Design, creation and in vitro testing of a reduced immunogenicity humanized anti-CD25 monoclonal antibody that retains functional activity
, Protein Engineering Design and Selection: Peds 32(12): 543-554 (2019)

Design, crystal structure determination, molecular dynamic simulation and MMGBSA calculations of novel p38-alpha MAPK inhibitors for combating Alzheimer's disease
, Journal of Biomolecular Structure and Dynamics 2021: 1-14 (2021)

Design, data linkage, and implementation considerations in the first cooperative group led study assessing financial outcomes in cancer patients and their informal caregivers
, Contemporary Clinical Trials 95: 106037 (2020)

Design, development and assessment of an essential oil based slow release vaporizer against mosquitoes
, Acta Tropica 210: 105573 (2020)

Design, development and deployment of a web-based interoperable registry for inherited retinal dystrophies in Portugal: the IRD-PT
, Orphanet Journal of Rare Diseases 15(1): 304 (2020)

Design, development and evaluation of a resistor-based multiplexing circuit for a 20×20 SiPM array
, Nuclear Instruments and Methods in Physics Research. Section A Accelerators Spectrometers Detectors and Associated Equipment 816: 40-46 (2016)

Design, development and in-vitro/in-vivo evaluation of intranasally delivered Rivastigmine and N-Acetyl Cysteine loaded bifunctional niosomes for applications in combinative treatment of Alzheimer's disease
, European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 2021 (2021)

Design, development and optimization of sustained release floating, bioadhesive and swellable matrix tablet of ranitidine hydrochloride
, Plos one 16(6): E0253391 (2021)

Design, development and performance evaluation of transportation container for sapota fruit
, Journal of Food Science and Technology (Mysore) 58(10): 4024-4033 (2021)

Design, development, and characterization of an idebenone-loaded poly-ε-caprolactone intravitreal implant as a new therapeutic approach for LHON treatment
, European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 2021 (2021)

Design, development, and deployment of an indication- and kidney function-based decision support tool to optimize treatment and reduce medication dosing errors
, Jamia Open 4(2): Ooab039 (2021)

Design, development, and evaluation of an interactive training simulator for teaching hospital information systems
, Journal of Education and Health Promotion 10: 205 (2021)

Design, development, and evaluation of the efficacy of a nucleic acid-free version of a bacterial ghost candidate vaccine against avian pathogenic E. coli (APEC) O78:K80 serotype
, Veterinary Research 51(1): 144 (2020)

Design, development, and evaluation of visual aids for communicating prescription drug instructions to nonliterate patients in rural Cameroon
, Patient Education and Counseling 31(3): 245-261 (1997)

Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis
, Biomaterials Science 8(16): 4467-4480 (2020)

Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors
, European Journal of Medicinal Chemistry 202: 112495 (2020)

Design, docking, and DFT investigations of 2,6-bis(3,4-dihydroxyphenyl)-3-phenethylpiperidin-4-one
, Heliyon 7(2): E06127 (2021)

Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers
, Bioorganic Chemistry 104: 104255 (2020)

Design, evaluation, and optimization of 3D printed truss scaffolds for bone tissue engineering
, Journal of the Mechanical Behavior of Biomedical Materials 120: 104594 (2021)

Design, execution, and analysis of CRISPR-Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans
, Nature Protocols 14(3): 955-975 (2019)

Design, expression, and purification of a multi-epitope vaccine against Helicobacter Pylori based on Melittin as adjuvant
, Microbial Pathogenesis 2021: 104970 (2021)

Design, expression, purification and crystallization of human 14-3-3ζ protein chimera with phosphopeptide from proapoptotic protein BAD
, Protein Expression and Purification 175: 105707 (2020)

Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment
, Nature Protocols 15(8): 2728-2757 (2020)

Design, fabrication and characterisation of drug-loaded vaginal films: State-of-the-art
, Journal of Controlled Release: Official Journal of the Controlled Release Society 327: 477-499 (2020)

Design, fabrication and characterization of Computer Generated Holograms for anti-counterfeiting applications using OAM beams as light decoders
, Scientific Reports 7(1): 18011 (2017)

Design, fabrication and control of soft robots
, Nature 521(7553): 467-475 (2015)

Design, fabrication and measurement of highly-dispersive mirrors with total internal reflection
, Optics Express 28(20): 29230-29238 (2020)

Design, fabrication, and characterisation of a silicon microneedle array for transdermal therapeutic delivery using a single step wet etch process
, European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 2021 (2021)

Design, fabrication, and characterization of broad beam transducers for fragmenting large renal calculi with burst wave lithotripsy
, Journal of the Acoustical Society of America 148(1): 44 (2020)

Design, fabrication, and characterization of graft co-polymer assisted ocular insert: a state of art in reducing post-operative pain
, Drug Development and Industrial Pharmacy 2020: 1-12 (2020)

Design, fabrication, and optical characterization of one-dimensional photonic crystals based on porous silicon assisted by in-situ photoacoustics
, Scientific Reports 9(1): 14732 (2019)

Design, fabrication, and optimization of a dual function three-layer scaffold for controlled release of metformin hydrochloride to alleviate fibrosis and accelerate wound healing
, Acta Biomaterialia 113: 144-163 (2020)

Design, fabrication, and validation of patient-specific electron tissue compensators for postmastectomy radiation therapy
, Physics and Imaging in Radiation Oncology 8: 38-43 (2018)

Design, formulation and evaluation of Chasmanthera dependens Hochst and Chenopodium ambrosioides Linn based gel for its analgesic and anti-inflammatory activities
, Heliyon 6(9): E04894 (2020)

Design, formulation and optimization of topical ethosomes using full factorial design: in-vitro and ex-vivo characterization
, Journal of Liposome Research 2021: 1-9 (2021)

Design, function and structure of a monomeric ClC transporter
, Nature 468(7325): 844-847 (2010)

Design, green synthesis, antioxidant activity screening, and evaluation of protective effect on cerebral ischemia reperfusion injury of novel monoenone monocarbonyl curcumin analogs
, Bioorganic Chemistry 114: 105080 (2021)

Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors
, Bioorganic Chemistry 104: 104350 (2020)

Design, implement, and diffuse scalable and sustainable solutions for dementia care
, Journal of the American Geriatrics Society 69(7): 1755-1762 (2021)

Design, implementation and characterization of a quantum-dot-based volumetric display
, Scientific Reports 5: 8472 (2015)

Design, implementation and evaluation of an education course to promote professional self-efficacy for breastfeeding care
, Nurse Education in Practice 45: 102799 (2020)

Design, implementation and evaluation of novel work-based clinical assessment tool: An e-portfolio with embedded Entrustable Professional Activities
, Nurse Education Today 107: 105101 (2021)

Design, implementation, and evaluation of a PRECEDE-PROCEED model-based intervention for oral and dental health among primary school students of Rafsanjan city: a mixed method study
, Bmc Public Health 21(1): 1609 (2021)

Design, in vitro bioactivity and in vivo influence on oxidative stress and matrix metalloproteinases of bioglasses in experimental skin wound
, Journal of Trace Elements in Medicine and Biology: Organ of the Society for Minerals and Trace Elements 68: 126846 (2021)

Design, manufacture and initial tests of a drug-eluting coronary stent
, Gaceta Medica de Mexico 156(4): 279-285 (2020)

Design, methodology, and baseline of whole city-million scale children and adolescents myopia survey (CAMS) in Wenzhou, China
, Eye and Vision 8(1): 31 (2021)

Design, methods, and baseline characteristics of a pilot, randomized, controlled trial of the effects of an electronic monitoring device on medication adherence in children with asthma
, Contemporary Clinical Trials Communications 21: 100706 (2021)

Design, microwave assisted synthesis, and molecular modeling study of some new 1,3,4-thiadiazole derivatives as potent anticancer agents and potential VEGFR-2 inhibitors
, Bioorganic Chemistry 112: 104923 (2021)

Design, microwave synthesis, and molecular docking studies of catalpol crotonates as potential neuroprotective agent of diabetic encephalopathy
, Scientific Reports 10(1): 20415 (2020)

Design, modeling, and performance analysis of a new dispensing system based on compliant mechanism
, Science Progress 103(2): 36850420923892 (2020)

Design, modification of phyllanthone derivatives as anti-diabetic and cytotoxic agents
, Natural Product Research 2020: 1-8 (2020)

Design, molecular docking analysis of an anti-inflammatory drug, computational analysis and intermolecular interactions energy studies of 1-benzothiophene-2-carboxylic acid
, Computational Biology and Chemistry 88: 107348 (2020)

Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma
, Bioorganic Chemistry 2020: 104532 (2020)

Design, optimization and analysis of large DNA and RNA nanostructures through interactive visualization, editing and molecular simulation
, Nucleic Acids Research 48(12): E72 (2020)

Design, optimization and evaluation of a microemulsion-based hydrogel with high malleability for enhanced transdermal delivery of levamisole
, International Journal of Pharmaceutics 2021: 120829 (2021)

Design, optimization and evaluation of co-surfactant free microemulsion-based hydrogel with low surfactant for enhanced transdermal delivery of lidocaine
, International Journal of Pharmaceutics 586: 119415 (2020)

Design, optimization and fabrication of a 28.3 THz nano-rectenna for infrared detection and rectification
, Scientific Reports 4: 4270 (2014)

Design, optimization, and in-vivo hypoglycaemic effect of nanosized glibenclamide for inhalation delivery
, Journal of Liposome Research 2020: 1-35 (2020)

Design, organisation and impact of treatment optimisation studies in breast, lung and colorectal cancer: The experience of the European Organisation for Research and Treatment of Cancer
, European Journal of Cancer 151: 221-232 (2021)

Design, organocatalytic synthesis, and bioactivity evaluation of enantiopure fluorinated LpxC inhibitors
, Organic and Biomolecular Chemistry 18(30): 5867-5878 (2020)

Design, preparation, characterization and formation mechanism of a novel kinetic CL-20-based cocrystal
, Acta Crystallographica Section B Structural Science Crystal Engineering and Materials 75(Pt 3): 310-317 (2019)

Design, preparation, characterization, and application of Mn x Cu 1-x O y /γ-Al 2 O 3 catalysts in ozonation to achieve simultaneous organic carbon and nitrogen removal in pyridine wastewater
, Science of the Total Environment 774: 145189 (2021)

Design, prototype development and pre-clinical validation of a novel instrument with a compliant steerable tip to facilitate endoscopic ear surgery
, Journal of Medical Engineering and Technology 2020: 1-13 (2020)

Design, quality, safety and efficacy of extensively hydrolyzed formula for management of cow's milk protein allergy: What are the challenges?
, Advances in Food and Nutrition Research 93: 147-204 (2020)

Design, rationale and analysis plan for the Stand Up for Health trial in contact centres: a stepped wedge feasibility study
, Pilot and Feasibility Studies 6: 139 (2020)

Design, rationale, and baseline characteristics of a pilot randomized clinical trial of nicotine treatment for pulmonary sarcoidosis
, Contemporary Clinical Trials Communications 20: 100669 (2020)

Design, reliability, and validity of a portable electronic device based on ergonomics for early screening of adolescent scoliosis
, Journal of Orthopaedic Translation 28: 83-89 (2021)

Design, scope and mechanism of highly active and selective chiral NHC-iridium catalysts for the intramolecular hydroamination of a variety of unactivated aminoalkenes
, Chemical Science 12(10): 3751-3767 (2021)

Design, screening and antibacterial activity evaluation of the novel antibacterial peptide KR-1
, Nan Fang Yi Ke da Xue Xue Bao 41(6): 923-930 (2021)

Design, simulation and analysis of micro electro-mechanical system microneedle for micropump in drug delivery systems
, IET Nanobiotechnology 15(5): 484-491 (2021)

Design, simulation and characterization of integrated photonic spectrographs for astronomy: generation-I AWG devices based on canonical layouts
, Optics Express 29(16): 24947-24971 (2021)

Design, simulation, and laboratory test of a single sludge drainage pipe for wastewater treatment sedimentation tank
, Water Science and Technology: a Journal of the International Association on Water Pollution Research 82(5): 905-917 (2020)

Design, structure and stability of a hyperthermophilic protein variant
, Nature Structural Biology 5(6): 470-475 (1998)

Design, structure-activity relationship study and biological evaluation of the thieno[3,2-c]isoquinoline scaffold as a potential anti-cancer agent
, Bioorganic and Medicinal Chemistry Letters 2021: 128327 (2021)

Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD)
, Bioorganic and Medicinal Chemistry Letters 30(22): 127601 (2020)

Design, synthesis ADMET and molecular docking of new imidazo[4,5-b]pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors
, Bioorganic Chemistry 102: 104105 (2020)

Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFR L858R/T790M
, Bioorganic and Medicinal Chemistry 28(19): 115680 (2020)

Design, synthesis and SAR study of novel C2-pyrazolopyrimidine amides and amide isosteres as allosteric integrase inhibitors
, Bioorganic and Medicinal Chemistry Letters 30(21): 127516 (2020)

Design, synthesis and SARs of novel telomerase inhibitors based on BIBR1532
, Bioorganic Chemistry 102: 104077 (2020)

Design, synthesis and agricultural evaluation of derivatives of N-Acyl-N-(m-fluoro-benzyl)-6-amino-coumarin
, Natural Product Research 2020: 1-7 (2020)

Design, synthesis and anti-HIV evaluation of 5-alkyl- 6-(benzo[d][1,3]dioxol-5-alkyl)-2-mercaptopyrimidin-4(3H)-ones as potent HIV-1 NNRTIs
, Bioorganic Chemistry 102: 104041 (2020)

Design, synthesis and anti-cancer activity of pyrrole-imidazole polyamides through target-downregulation of c-kit gene expression
, European Journal of Medicinal Chemistry 207: 112704 (2020)

Design, synthesis and anti-fibrosis evaluation of imidazo[1,2-a]pyridine derivatives as potent ATX inhibitors
, Bioorganic and Medicinal Chemistry 46: 116362 (2021)

Design, synthesis and anti-inflammatory activity of 3-amino acid derivatives of ocotillol-type sapogenins
, European Journal of Medicinal Chemistry 202: 112507 (2020)

Design, synthesis and anti-inflammatory activity of imidazol-5-yl pyridine derivatives as p38α/MAPK14 inhibitor
, Bioorganic and Medicinal Chemistry 31: 115969 (2020)

Design, synthesis and anti-influenza virus activity of furan-substituted spirothiazolidinones
, Bioorganic Chemistry 112: 104958 (2021)

Design, synthesis and anti-rheumatoid arthritis evaluation of double-ring conjugated enones
, Bioorganic Chemistry 109: 104701 (2021)

Design, synthesis and anti-tumor activities of carbamate derivatives of cinobufagin
, Steroids 164: 108749 (2020)

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists
, European Journal of Medicinal Chemistry 226: 113812 (2021)

Design, synthesis and antibacterial activity evaluation of pleuromutilin derivatives according to twin drug theory
, Journal of Asian Natural Products Research 2021: 1-17 (2021)

Design, synthesis and antibacterial activity of a novel alkylide: 3-O-(3-aryl-propenyl)clarithromycin derivatives
, Journal of Antibiotics 62(11): 605-611 (2009)

Design, synthesis and antibacterial activity of chalcones against MSSA and MRSA planktonic cells and biofilms
, Bioorganic Chemistry 116: 105279 (2021)

Design, synthesis and antibacterial activity of novel ketolides bearing an aryltetrazolyl-substituted alkyl side chain
, Journal of Antibiotics 64(8): 571-581 (2011)

Design, synthesis and antibacterial evaluation of novel C-11, C-9 or C-2'-substituted 3-O-descladinosyl-3-ketoclarithromycin derivatives
, Bioorganic and Medicinal Chemistry Letters 2021: 128110 (2021)

Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety
, Bioorganic and Medicinal Chemistry Letters 32: 127660 (2020)

Design, synthesis and anticancer activity of 2-amidomethoxy-1,4-naphthoquinones and its conjugates with Biotin/polyamine
, Bioorganic and Medicinal Chemistry Letters 2020: 127685 (2020)

Design, synthesis and anticancer activity of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-1,2,3-thiadiazoles as microtubule-destabilizing agents
, Bioorganic Chemistry 2020: 104199 (2020)

Design, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles
, Bioorganic and Medicinal Chemistry Letters 49: 128307 (2021)

Design, synthesis and anticancer evaluation of new 4-anilinoquinoline-3-carbonitrile derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers
, Bioorganic Chemistry 114: 105200 (2021)

Design, synthesis and anticancer/antiestrogenic activities of novel indole-benzimidazoles
, Bioorganic Chemistry 100: 103929 (2020)

Design, synthesis and anticonvulsant activity of new imidazolidindione and imidazole derivatives
, Bioorganic Chemistry 101: 104020 (2020)

Design, synthesis and antihypertensive evaluation of novel codrugs with combined angiotensin type 1 receptor antagonism and neprilysin inhibition
, European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 2021: 105731 (2021)

Design, synthesis and antimicrobial activity of novel 2-aminothiophene containing cyclic and heterocyclic moieties
, Bioorganic and Medicinal Chemistry Letters 2021: 128117 (2021)

Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives
, European Journal of Medicinal Chemistry 202: 112513 (2020)

Design, synthesis and antimicrobial studies of some polymyxin analogues
, Journal of Antibiotics 73(3): 158-166 (2020)

Design, synthesis and antimycobacterial activity of new benzothiazinones inspired by rifampicin/rifapentine
, Bioorganic Chemistry 102: 104135 (2020)

Design, synthesis and antimycobacterial evaluation of novel adamantane and adamantanol analogues effective against drug-resistant tuberculosis
, Bioorganic Chemistry 2020: 104486 (2020)

Design, synthesis and antiproliferative activity evaluation of fluorine-containing chalcone derivatives
, Journal of Biomolecular Structure and Dynamics 2020: 1-26 (2020)

Design, synthesis and antiproliferative activity of novel 2,4-diamino-5-methyleneaminopyrimidine derivatives as potential anticancer agents
, Bioorganic and Medicinal Chemistry Letters 2021: 128213 (2021)

Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity
, Bioorganic Chemistry 105: 104446 (2020)

Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives
, Bioorganic Chemistry 100: 103933 (2020)

Design, synthesis and antitumor activities of thiazole-containing mitochondrial targeting agents
, Bioorganic Chemistry 115: 105271 (2021)

Design, synthesis and antitumor activity evaluation of Chrysamide B derivatives
, Bioorganic Chemistry 111: 104828 (2021)

Design, synthesis and antitumor activity evaluation of novel HDAC inhibitors with tetrahydrobenzothiazole as the skeleton
, Bioorganic Chemistry 108: 104652 (2021)

Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives
, Bioorganic and Medicinal Chemistry Letters 2021: 128268 (2021)

Design, synthesis and antitumor activity of icotinib derivatives
, Bioorganic Chemistry 105: 104421 (2020)

Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations
, European Journal of Medicinal Chemistry 203: 112511 (2020)

Design, synthesis and antitumor activity of phthalazine-1,4-dione-based menaquinone analogs
, Bioorganic and Medicinal Chemistry Letters 2021: 128065 (2021)

Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA
, European Journal of Medicinal Chemistry 2020: 112951 (2020)

Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives as potential c-Met inhibitors
, Bioorganic Chemistry 104: 104356 (2020)

Design, synthesis and antitumour evaluation of novel anthraquinone derivatives
, Bioorganic Chemistry 2020: 104395 (2020)

Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives
, European Journal of Medicinal Chemistry 202: 112516 (2020)

Design, synthesis and application of a dual-functional fluorescent probe for reactive oxygen species and viscosity
, Spectrochimica Acta. Part A Molecular and Biomolecular Spectroscopy 246: 119059 (2021)

Design, synthesis and application of carbazole macrocycles in anion sensors
, Beilstein Journal of Organic Chemistry 16: 1901-1914 (2020)

Design, synthesis and application of near-infrared fluorescence probe IR-780-Crizotinib in detection of ALK positive tumors
, Protein Expression and Purification 187: 105952 (2021)

Design, synthesis and bioactive evaluation of geniposide derivatives for antihyperuricemic and nephroprotective effects
, Bioorganic Chemistry 116: 105321 (2021)

Design, synthesis and bioactivity evaluation of fisetin derivatives as potential anti-inflammatory agents against LPS-induced acute lung injury
, Bioorganic and Medicinal Chemistry 49: 116456 (2021)

Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors
, European Journal of Medicinal Chemistry 205: 112645 (2020)

Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity
, Bioorganic and Medicinal Chemistry Letters 2021: 127853 (2021)

Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ
, Bioorganic Chemistry 116: 105342 (2021)

Design, synthesis and bioactivity study of evodiamine derivatives as multifunctional agents for the treatment of hepatocellular carcinoma
, Bioorganic Chemistry 114: 105154 (2021)

Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell
, European Journal of Medicinal Chemistry 216: 113336 (2021)

Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII
, Bioorganic and Medicinal Chemistry 44: 116279 (2021)

Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors
, European Journal of Medicinal Chemistry 226: 113826 (2021)

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core
, European Journal of Medicinal Chemistry 2020: 112959 (2020)

Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors
, European Journal of Medicinal Chemistry 204: 112637 (2020)

Design, synthesis and biological activities of benzo[d]imidazo[1,2-a]imidazole derivatives as TRPM2-specfic inhibitors
, European Journal of Medicinal Chemistry 225: 113750 (2021)

Design, synthesis and biological activities of novel pleuromutilin derivatives with a substituted triazole moiety as potent antibacterial agents
, European Journal of Medicinal Chemistry 204: 112604 (2020)

Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists
, European Journal of Medicinal Chemistry 207: 112774 (2020)

Design, synthesis and biological activity evaluation of novel 4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl) oxy) pyridine-2-yl) amino derivatives as potent transforming growth factor-β (TGF-β) type I receptor inhibitors
, Bioorganic and Medicinal Chemistry Letters 30(16): 127339 (2020)

Design, synthesis and biological activity evaluation of novel scopoletin-NO donor derivatives against MCF-7 human breast cancer in vitro and in vivo
, European Journal of Medicinal Chemistry 224: 113701 (2021)

Design, synthesis and biological activity of 1,4-quinone moiety attached to betulin derivatives as potent DT-diaphorase substrate
, Bioorganic Chemistry 2020: 104478 (2020)

Design, synthesis and biological activity of N-(amino)piperazine-containing benzothiazinones against Mycobacterium tuberculosis
, European Journal of Medicinal Chemistry 218: 113398 (2021)

Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors
, Bioorganic and Medicinal Chemistry 28(23): 115811 (2020)

Design, synthesis and biological activity of bis-sulfonyl-BODIPY probes for tumor cell imaging
, Bioorganic and Medicinal Chemistry Letters 2021: 128292 (2021)

Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors
, Bioorganic and Medicinal Chemistry 28(15): 115600 (2020)

Design, synthesis and biological activity of protaxols
, Nature 364(6436): 464-466 (1993)

Design, synthesis and biological assessment of acridine derivatives containing 1,3,4-thiadiazole moiety as novel selective acetylcholinesterase inhibitors
, Bioorganic Chemistry 105: 104457 (2020)

Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4 H )-yl)methyl) pyridin-1-ium derivatives (BOPs) as potential dual inhibitors of acetylcholinesterase and butyrylcholinesterase
, Heliyon 7(4): E06683 (2021)

Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety
, European Journal of Medicinal Chemistry 2020: 112918 (2020)

Design, synthesis and biological assessment of novel CDK4 inhibitor with potent anticancer activity
, Bioorganic Chemistry 109: 104717 (2021)

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1 H -tetrazols as novel microtubule destabilizers
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 549-560 (2021)

Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors
, European Journal of Medicinal Chemistry 220: 113482 (2021)

Design, synthesis and biological evaluation of 2,3-dihydro-[1,4]dioxino[2,3-f]quinazoline derivatives as EGFR inhibitors
, Bioorganic Chemistry 110: 104743 (2021)

Design, synthesis and biological evaluation of 2,3-dihydroimidazo[2,1-b]thiazoles as dual EGFR and IGF1R inhibitors
, Bioorganic Chemistry 115: 105151 (2021)

Design, synthesis and biological evaluation of 2-indolinone derivatives as PAK1 inhibitors in MDA-MB-231 cells
, Bioorganic and Medicinal Chemistry Letters 30(17): 127355 (2020)

Design, synthesis and biological evaluation of 2-methyl-(1,1'-biphenyl)-pyrimidine conjugates
, Bioorganic and Medicinal Chemistry Letters 30(16): 127328 (2020)

Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents
, Rsc Advances 11(8): 4555-4571 (2021)

Design, synthesis and biological evaluation of 2-styryl-5-hydroxy-4-pyrone derivatives and analogues as multiple functional agents with the potential for the treatment of Alzheimer's disease
, Bioorganic and Medicinal Chemistry 44: 116306 (2021)

Design, synthesis and biological evaluation of 2-substituted-6-[(4-substituted-1-piperidyl)methyl]-1H-benzimidazoles as inhibitors of ebola virus infection
, European Journal of Medicinal Chemistry 214: 113211 (2021)

Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors
, European Journal of Medicinal Chemistry 221: 113526 (2021)

Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H 2 S) donors as potent EGFR inhibitors against L858R resistance mutation
, European Journal of Medicinal Chemistry 202: 112522 (2020)

Design, synthesis and biological evaluation of 4-aryl-5-aminoalkyl-thiazole-2-amines derivatives as ROCK II inhibitors
, Bioorganic and Medicinal Chemistry 28(19): 115683 (2020)

Design, synthesis and biological evaluation of 7-(5-((substituted - amino)-methyl)-thiophen-2-yl)-spiro-[chroman-2,4'-piperidin]-4-one hydrochloride analogues as anticancer agents
, Bioorganic Chemistry 112: 104865 (2021)

Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents
, European Journal of Medicinal Chemistry 200: 112405 (2020)

Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidine derivatives containing 1,8-naphthyridine-4-one fragment
, European Journal of Medicinal Chemistry 215: 113273 (2021)

Design, synthesis and biological evaluation of N-anthraniloyl tryptamine derivatives as pleiotropic molecules for the therapy of malignant glioma
, European Journal of Medicinal Chemistry 222: 113564 (2021)

Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands
, Acta Pharmacologica Sinica 36(7): 887-894 (2015)

Design, synthesis and biological evaluation of Tozadenant analogues as adenosine A 2A receptor ligands
, European Journal of Medicinal Chemistry 214: 113214 (2021)

Design, synthesis and biological evaluation of a new thieno[2,3- d ]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell lines
, Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1641-1656 (2020)

Design, synthesis and biological evaluation of a novel N-aminoacyl derivative of amphotericin B methyl ester as an antifungal agent
, European Journal of Medicinal Chemistry 211: 113104 (2020)

Design, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-β probes
, Scientific Reports 9(1): 13187 (2019)

Design, synthesis and biological evaluation of a series of iron and copper chelating deferiprone derivatives as new agents active against Candida albicans
, Bioorganic and Medicinal Chemistry Letters 2021: 128087 (2021)

Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors
, European Journal of Medicinal Chemistry 226: 113845 (2021)

Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway
, Bioorganic Chemistry 111: 104872 (2021)

Design, synthesis and biological evaluation of anticholinesterase peptides: Fragment-based vs. template-based peptide design
, Bioorganic Chemistry 105: 104351 (2020)

Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases
, European Journal of Medicinal Chemistry 227: 113904 (2021)

Design, synthesis and biological evaluation of bivalent ligands against A(1)-D(1) receptor heteromers
, Acta Pharmacologica Sinica 34(3): 441-452 (2013)

Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction
, European Journal of Medicinal Chemistry 218: 113383 (2021)

Design, synthesis and biological evaluation of cinnamamide-quinazoline derivatives as potential EGFR inhibitors to reverse T790M mutation
, Bioorganic Chemistry 117: 105420 (2021)

Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents
, Rsc Medicinal Chemistry 12(8): 1374-1380 (2021)

Design, synthesis and biological evaluation of coumarin-based N-hydroxycinnamamide derivatives as novel histone deacetylase inhibitors with anticancer activities
, Bioorganic Chemistry 101: 104023 (2020)

Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis
, European Journal of Medicinal Chemistry 206: 112538 (2020)

Design, synthesis and biological evaluation of dihydrofurocoumarin derivatives as potent neuraminidase inhibitors
, Bioorganic and Medicinal Chemistry Letters 2021: 127839 (2021)

Design, synthesis and biological evaluation of dipeptides as novel non-covalent 20S proteasome inhibitors
, Journal of Asian Natural Products Research 2021: 1-13 (2021)

Design, synthesis and biological evaluation of double fatty chain-modified glucagon-like peptide-1 conjugates
, Bioorganic and Medicinal Chemistry 44: 116291 (2021)

Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold
, Bioorganic and Medicinal Chemistry Letters 2021: 128215 (2021)

Design, synthesis and biological evaluation of dual mTOR/HDAC6 inhibitors in MDA-MB-231 cells
, Bioorganic and Medicinal Chemistry Letters 2021: 128204 (2021)

Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer's disease
, Bioorganic Chemistry 103: 104109 (2020)

Design, synthesis and biological evaluation of edaravone derivatives bearing the N -benzyl pyridinium moiety as multifunctional anti-Alzheimer's agents
, Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1596-1605 (2020)

Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors
, European Journal of Medicinal Chemistry 223: 113631 (2021)

Design, synthesis and biological evaluation of glycolamide, glycinamide, and β-amino carbonyl 1,2,4-triazole derivatives as DPP-4 inhibitors
, Bioorganic Chemistry 114: 105049 (2021)

Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease
, European Journal of Medicinal Chemistry 222: 113554 (2021)

Design, synthesis and biological evaluation of hybrid of ubenimex-fluorouracil for hepatocellular carcinoma therapy
, Bioorganic Chemistry 116: 105343 (2021)

Design, synthesis and biological evaluation of hybrids of β-carboline and salicylic acid as potential anticancer and apoptosis inducing agents
, Scientific Reports 6: 36238 (2016)

Design, synthesis and biological evaluation of imidazole and triazole-based carbamates as novel aromatase inhibitors
, European Journal of Medicinal Chemistry 211: 113115 (2020)

Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors
, Bioorganic Chemistry 103: 104124 (2020)

Design, synthesis and biological evaluation of imidazolopyridone derivatives as novel BRD4 inhibitors
, Bioorganic and Medicinal Chemistry 2020: 115857 (2020)

Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors
, Bioorganic and Medicinal Chemistry 40: 116186 (2021)

Design, synthesis and biological evaluation of indanone-chalcone hybrids as potent and selective hCES2A inhibitors
, European Journal of Medicinal Chemistry 209: 112856 (2020)

Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors
, European Journal of Medicinal Chemistry 208: 112780 (2020)

Design, synthesis and biological evaluation of indole-based [1,2,4]triazolo[4,3-a] pyridine derivatives as novel microtubule polymerization inhibitors
, European Journal of Medicinal Chemistry 223: 113629 (2021)

Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors
, Bioorganic and Medicinal Chemistry Letters 2021: 128409 (2021)

Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors
, Bioorganic Chemistry 102: 104064 (2020)

Design, synthesis and biological evaluation of mono- and bisquinoline methanamine derivatives as potential antiplasmodial agents
, Bioorganic and Medicinal Chemistry Letters 2021: 127855 (2021)

Design, synthesis and biological evaluation of naphthalene-derived (arylalkyl)azoles containing heterocyclic linkers as new anticonvulsants: A comprehensive in silico, in vitro, and in vivo study
, European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 2021: 105974 (2021)

Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease
, Bioorganic and Medicinal Chemistry Letters 2021: 128316 (2021)

Design, synthesis and biological evaluation of new Myo-inositol derivatives as potential RAS inhibitors
, Bioorganic and Medicinal Chemistry Letters 30(16): 127290 (2020)

Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease
, European Journal of Medicinal Chemistry 212: 113124 (2020)

Design, synthesis and biological evaluation of new bivalent quinazoline analogues as IAP antagonists
, Bioorganic and Medicinal Chemistry Letters 2020: 127676 (2020)

Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant EGFR (L858R and T790M)
, Bioorganic Chemistry 105: 104274 (2020)

Design, synthesis and biological evaluation of novel (E)-2-benzylidene-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)hydrazine-1-carboxamide derivatives as α-glucosidase inhibitors
, Bioorganic and Medicinal Chemistry Letters 2021: 128413 (2021)

Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM)
, Bioorganic Chemistry 103: 104189 (2020)

Design, synthesis and biological evaluation of novel 1,2,3-triazole analogues of Imidazo-[1,2-a]-pyridine-3-carboxamide against Mycobacterium tuberculosis
, Toxicology in Vitro: An International Journal Published in Association with Bibra 2021: 105137 (2021)

Design, synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as anti-glioblastoma agents targeting the AKT pathway
, Bioorganic Chemistry 105: 104362 (2020)

Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway
, Bioorganic and Medicinal Chemistry 43: 116265 (2021)

Design, synthesis and biological evaluation of novel 2-(4-(1H-indazol-6-yl)-1H-pyrazol-1-yl)acetamide derivatives as potent VEGFR-2 inhibitors
, European Journal of Medicinal Chemistry 213: 113192 (2021)

Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs
, Bioorganic Chemistry 101: 104013 (2020)

Design, synthesis and biological evaluation of novel 3 1 -hexyloxy chlorin e 6 -based 15 2 - or 13 1 -amino acid derivatives as potent photosensitizers for photodynamic therapy
, European Journal of Medicinal Chemistry 207: 112715 (2020)

Design, synthesis and biological evaluation of novel 4-(pyrrolo[2,3-d]pyrimidine-4-yloxy)benzamide derivatives as potential antitumor agents
, Bioorganic and Medicinal Chemistry Letters 2020: 127740 (2020)

Design, synthesis and biological evaluation of novel 4-phenoxypyridine based 3-oxo-3,4-dihydroquinoxaline-2-carboxamide derivatives as potential c-Met kinase inhibitors
, Bioorganic Chemistry 105: 104371 (2020)

Design, synthesis and biological evaluation of novel 5-(imidazolyl-methyl) thiazolidinediones as antidiabetic agents
, Bioorganic Chemistry 115: 105162 (2021)

Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors
, Bioorganic and Medicinal Chemistry 28(15): 115601 (2020)

Design, synthesis and biological evaluation of novel 7H-benzo [c] [1, 3] dioxolo [4, 5-f] chromen-7-one derivatives with potential anti-tumor activity
, Bioorganic Chemistry 105: 104381 (2020)

Design, synthesis and biological evaluation of novel FXIa inhibitors with 2-phenyl-1H-imidazole-5-carboxamide moiety as P1 fragment
, European Journal of Medicinal Chemistry 220: 113437 (2021)

Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer
, European Journal of Medicinal Chemistry 205: 112648 (2020)

Design, synthesis and biological evaluation of novel N-sulfonylamidine-based derivatives as c-Met inhibitors via Cu-catalyzed three-component reaction
, European Journal of Medicinal Chemistry 200: 112470 (2020)

Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities
, Bioorganic and Medicinal Chemistry 46: 116376 (2021)

Design, synthesis and biological evaluation of novel arylpropionic esters for the treatment of acute kidney injury
, Bioorganic Chemistry 105: 104455 (2020)

Design, synthesis and biological evaluation of novel benzodioxole derivatives as COX inhibitors and cytotoxic agents
, Bmc Chemistry 14(1): 54 (2020)

Design, synthesis and biological evaluation of novel benzofuran derivatives as potent LSD1 inhibitors
, European Journal of Medicinal Chemistry 220: 113501 (2021)

Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis
, European Journal of Medicinal Chemistry 213: 113171 (2021)

Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents
, Bioorganic Chemistry 111: 104882 (2021)

Design, synthesis and biological evaluation of novel c-Met/HDAC dual inhibitors
, Bioorganic and Medicinal Chemistry Letters 30(23): 127610 (2020)

Design, synthesis and biological evaluation of novel carbohydrate-based sulfonamide derivatives as antitumor agents
, Bioorganic Chemistry 104: 104237 (2020)

Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors
, Bioorganic and Medicinal Chemistry 2020: 115853 (2020)

Design, synthesis and biological evaluation of novel chroman derivatives as non-selective acetyl-CoA carboxylase inhibitors
, Bioorganic Chemistry 101: 103943 (2020)

Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease
, Bioorganic and Medicinal Chemistry Letters 2021: 128212 (2021)

Design, synthesis and biological evaluation of novel diazaspirodecanone derivatives containing piperidine-4-carboxamide as chitin synthase inhibitors and antifungal agents
, Bioorganic Chemistry 114: 105108 (2021)

Design, synthesis and biological evaluation of novel estrone phosphonates as high affinity organic anion-transporting polypeptide 2B1 (OATP2B1) inhibitors
, Bioorganic Chemistry 112: 104914 (2021)

Design, synthesis and biological evaluation of novel fluoro-substituted benzimidazole derivatives with anti-hypertension activities
, Bioorganic Chemistry 101: 104042 (2020)

Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents
, Bioorganic and Medicinal Chemistry 28(16): 115608 (2020)

Design, synthesis and biological evaluation of novel heptamethine cyanine dye-erlotinib conjugates as antitumor agents
, Bioorganic and Medicinal Chemistry Letters 30(23): 127557 (2020)

Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma
, European Journal of Medicinal Chemistry 225: 113824 (2021)

Design, synthesis and biological evaluation of novel imidazole-chalcone derivatives as potential anticancer agents and tubulin polymerization inhibitors
, Bioorganic Chemistry 112: 104904 (2021)

Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents
, Bioorganic and Medicinal Chemistry 32: 115960 (2021)

Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors
, Bioorganic and Medicinal Chemistry Letters 2021: 128169 (2021)

Design, synthesis and biological evaluation of novel naphthoquinone-4-aminobenzensulfonamide/carboxamide derivatives as proteasome inhibitors
, European Journal of Medicinal Chemistry 209: 112890 (2020)

Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo
, European Journal of Medicinal Chemistry 227: 113888 (2021)

Design, synthesis and biological evaluation of novel osthole-based derivatives as potential neuroprotective agents
, Bioorganic and Medicinal Chemistry Letters 30(24): 127633 (2020)

Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome
, Bioorganic and Medicinal Chemistry 38: 116138 (2021)

Design, synthesis and biological evaluation of novel pleuromutilin derivatives containing piperazine and 1,2,3-triazole linker
, Bioorganic Chemistry 105: 104398 (2020)

Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition
, Bioorganic Chemistry 104: 104208 (2020)

Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy
, European Journal of Medicinal Chemistry 201: 112428 (2020)

Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors
, Bioorganic and Medicinal Chemistry Letters 30(16): 127329 (2020)

Design, synthesis and biological evaluation of novel pyrazolopyrimidone derivatives as potent PDE1 inhibitors
, Bioorganic Chemistry 114: 105104 (2021)

Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors
, Bioorganic Chemistry 115: 105268 (2021)

Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier
, Bioorganic and Medicinal Chemistry 28(12): 115544 (2020)

Design, synthesis and biological evaluation of novel pyxinol derivatives with anti-heart failure activity
, Biomedicine and PharmacoTherapy 133: 111050 (2021)

Design, synthesis and biological evaluation of novel scaffold benzo[4,5]imidazo [1,2-a]pyrazin-1-amine: Towards adenosine A 2A receptor (A 2A AR) antagonist
, European Journal of Medicinal Chemistry 210: 113040 (2020)

Design, synthesis and biological evaluation of novel tetrahydrothieno [2,3-c]pyridine substitued benzoyl thiourea derivatives as PAK1 inhibitors in triple negative breast cancer
, Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1524-1538 (2020)

Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors
, Bioorganic and Medicinal Chemistry 29: 115878 (2020)

Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells
, Bioorganic Chemistry 114: 105015 (2021)

Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 1694-1702 (2021)

Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
, Bioorganic and Medicinal Chemistry 31: 115953 (2020)

Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells
, European Journal of Medicinal Chemistry 2020: 112970 (2020)

Design, synthesis and biological evaluation of novel triaryldimethylaminobutan-2-ol derivatives against Mycobacterium tuberculosis
, Bioorganic Chemistry 102: 104054 (2020)

Design, synthesis and biological evaluation of pleuromutilin-Schiff base hybrids as potent anti-MRSA agents in vitro and in vivo
, European Journal of Medicinal Chemistry 223: 113624 (2021)

Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation
, Bioorganic and Medicinal Chemistry Letters 30(16): 127327 (2020)

Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects
, Bioorganic Chemistry 2020: 104564 (2020)

Design, synthesis and biological evaluation of pyrazole-aromatic containing carboxamides as potent SDH inhibitors
, European Journal of Medicinal Chemistry 214: 113230 (2021)

Design, synthesis and biological evaluation of pyrazolo[3,4- d ]pyridazinone derivatives as covalent FGFR inhibitors
, Acta Pharmaceutica Sinica. B 11(3): 781-794 (2021)

Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors
, European Journal of Medicinal Chemistry 205: 112638 (2020)

Design, synthesis and biological evaluation of pyridinylmethylenepiperidine derivatives as potent 5-HT 1F receptor agonists for migraine therapy
, European Journal of Medicinal Chemistry 225: 113782 (2021)

Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors
, European Journal of Medicinal Chemistry 225: 113794 (2021)

Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease
, European Journal of Medicinal Chemistry 202: 112475 (2020)

Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors
, Bioorganic and Medicinal Chemistry Letters 30(21): 127459 (2020)

Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
, European Journal of Medicinal Chemistry 209: 112857 (2020)

Design, synthesis and biological evaluation of selective histone deacetylase 6 (HDAC6) inhibitors bearing benzoindazole or pyrazoloindazole scaffold as surface recognition motif
, Bioorganic Chemistry 111: 104910 (2021)

Design, synthesis and biological evaluation of selective hybrid coumarin-thiazolidinedione aldose reductase-II inhibitors as potential antidiabetics
, Bioorganic Chemistry 114: 104970 (2021)

Design, synthesis and biological evaluation of some new 2-Pyrazoline derivatives as potential anticancer agents
, Bioorganic Chemistry 102: 104063 (2020)

Design, synthesis and biological evaluation of sphingosine-1-phosphate receptor 2 antagonists as potent 5-FU-resistance reversal agents for the treatment of colorectal cancer
, European Journal of Medicinal Chemistry 225: 113775 (2021)

Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors
, European Journal of Medicinal Chemistry 216: 113300 (2021)

Design, synthesis and biological evaluation of tanshinone IIA-based analogues: Potent inhibitors of microtubule formation and angiogenesis
, European Journal of Medicinal Chemistry 224: 113708 (2021 )

Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition
, Bioorganic Chemistry 104: 104197 (2020)

Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity
, European Journal of Medicinal Chemistry 209: 112912 (2021)

Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors
, Bioorganic and Medicinal Chemistry Letters 30(21): 127508 (2020)

Design, synthesis and biological evaluation of triazole-oxadiazole conjugates for the management of cognitive dysfunction
, Bioorganic Chemistry 103: 104151 (2020)

Design, synthesis and biological evaluation of tyrosinase-targeting PROTACs
, European Journal of Medicinal Chemistry 226: 113850 (2021)

Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors
, European Journal of Medicinal Chemistry 207: 112716 (2020)

Design, synthesis and biological evaluation of vortioxetine derivatives as new COX-1/2 inhibitors in human monocytes
, Bioorganic and Medicinal Chemistry 28(23): 115760 (2020)

Design, synthesis and biological evaluation of water soluble and non-aggregated silicon phthalocyanines, naphthalocyanines against A549, SNU-398, SK-MEL128, DU-145, BT-20 and HFC cell lines as potential anticancer agents
, Bioorganic Chemistry 107: 104637 (2021)

Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1
, European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 152: 105455 (2020)

Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects
, Journal of Controlled Release: Official Journal of the Controlled Release Society 2021 (2021)

Design, synthesis and biological evaluations of a series of Pyrido[1,2-a]pyrimidinone derivatives as novel selective FGFR inhibitors
, European Journal of Medicinal Chemistry 220: 113499 (2021)

Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors
, Bioorganic Chemistry 109: 104736 (2021)

Design, synthesis and biomedical evaluation of mostotrin, a new water soluble tryptanthrin derivative
, International Journal of Molecular Medicine 46(4): 1335-1346 (2020)

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin
, Biochemical and Biophysical Research Communications 533(3): 559-564 (2020)

Design, synthesis and characterization of lysozyme-gentisic acid dual-functional conjugates with antibacterial/antioxidant activities
, Food Chemistry 370: 131032 (2021)

Design, synthesis and characterization of novel gamma‑aminobutyric acid type A receptor ligands
, Arkivoc: Free Online Journal of Organic Chemistry 2020(Pt 7): 242-256 (2020)

Design, synthesis and characterization of structurally dynamic cyclic N,S-acetals
, Chemical Communications 56(64): 9118-9121 (2020)

Design, synthesis and comparative analysis of triphenyl-1,2,3-triazoles as anti-proliferative agents
, European Journal of Medicinal Chemistry 207: 112813 (2020)

Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents
, Scientific Reports 11(1): 7846 (2021)

Design, synthesis and drug resistance reversal potential of novel curcumin mimics Van D: Synergy potential of curcumin mimics
, Bioorganic Chemistry 2020: 104454 (2020)

Design, synthesis and evaluation of 1-benzyl-1H-imidazole-5-carboxamide derivatives as potent TGR5 agonists
, Bioorganic and Medicinal Chemistry 32: 115972 (2020)

Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents
, European Journal of Medicinal Chemistry 226: 113852 (2021)

Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y 14 R antagonists with potential high efficiency against acute gouty arthritis
, European Journal of Medicinal Chemistry 216: 113313 (2021)

Design, synthesis and evaluation of PD-L1 peptide antagonists as new anticancer agents for immunotherapy
, Bioorganic and Medicinal Chemistry 30: 115951 (2020)

Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis
, Bioorganic and Medicinal Chemistry 28(20): 115697 (2020)

Design, synthesis and evaluation of a tripodal receptor for phosphatidylinositol phosphates
, Scientific Reports 10(1): 18450 (2020)

Design, synthesis and evaluation of anti-proliferative activity of 2-aryl-4-aminoquinazoline derivatives as EGFR inhibitors
, Bioorganic Chemistry 112: 104848 (2021)

Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles
, Bioorganic Chemistry 104: 103909 (2020)

Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents
, Bioorganic Chemistry 101: 103960 (2020)

Design, synthesis and evaluation of calix[4]arene-based carbonyl amide derivatives with antitumor activities
, European Journal of Medicinal Chemistry 2020: 112984 (2020)

Design, synthesis and evaluation of carbamate-linked uridyl-based inhibitors of human ST6Gal I
, Bioorganic and Medicinal Chemistry 28(14): 115561 (2020)

Design, synthesis and evaluation of carbazole derivatives as potential antimicrobial agents
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 295-306 (2021)

Design, synthesis and evaluation of cholinesterase hybrid inhibitors using a natural steroidal alkaloid as precursor
, Bioorganic Chemistry 111: 104893 (2021)

Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer's disease
, Bioorganic Chemistry 112: 104879 (2021)

Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents
, European Journal of Medicinal Chemistry 208: 112773 (2020)

Design, synthesis and evaluation of dihydropyranoindole derivatives as potential cholinesterase inhibitors against Alzheimer's disease
, Bioorganic Chemistry 110: 104770 (2021)

Design, synthesis and evaluation of enzyme-responsive fluorogenic probes based on pyridine-flanked diketopyrrolopyrrole dyes
, Spectrochimica Acta. Part A Molecular and Biomolecular Spectroscopy 2020: 119179 (2020)

Design, synthesis and evaluation of heteroaryldihydropyrimidine analogues bearing spiro ring as hepatitis B virus capsid protein inhibitors
, European Journal of Medicinal Chemistry 225: 113780 (2021)

Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs
, Nature Protocols 11(4): 781-794 (2016)

Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity
, European Journal of Medicinal Chemistry 222: 113609 (2021)

Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi
, European Journal of Medicinal Chemistry 225: 113740 (2021)

Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents
, European Journal of Medicinal Chemistry 221: 113480 (2021)

Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFR T790M mutant cell lines
, European Journal of Medicinal Chemistry 213: 113173 (2021)

Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease
, European Journal of Medicinal Chemistry 216: 113310 (2021)

Design, synthesis and evaluation of novel enzalutamide analogues as potential anticancer agents
, Heliyon 7(3): E06227 (2021)

Design, synthesis and evaluation of novel indirubin-based N-hydroxybenzamides, N-hydroxypropenamides and N-hydroxyheptanamides as histone deacetylase inhibitors and antitumor agents
, Bioorganic and Medicinal Chemistry Letters 30(22): 127537 (2020)

Design, synthesis and evaluation of novel levoglucosenone derivatives as promising anticancer agents
, Bioorganic and Medicinal Chemistry Letters 30(14): 127247 (2020)

Design, synthesis and evaluation of novel β-carboline ester analogues as potential anti-leishmanial agents
, Journal of Biomolecular Structure and Dynamics 2021: 1-16 (2021)

Design, synthesis and evaluation of pyrazolopyrimidinone derivatives as novel PDE9A inhibitors for treatment of Alzheimer's disease
, Bioorganic and Medicinal Chemistry Letters 30(14): 127254 (2020)

Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR)
, Bioorganic Chemistry 115: 105202 (2021)

Design, synthesis and evaluation of tetrahydrocarbazole derivatives as potential hypoglycemic agents
, Bioorganic Chemistry 115: 105172 (2021)

Design, synthesis and evaluation of β-lactam antigenic peptide hybrids; unusual opening of the β-lactam ring in acidic media
, Organic and Biomolecular Chemistry 8(23): 5345-5353 (2010)

Design, synthesis and herbicidal activities of p -menth-3-en-1-amine thiourea derivatives
, Natural Product Research 2021: 1-8 (2021)

Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
, European Journal of Medicinal Chemistry 204: 112599 (2020)

Design, synthesis and imaging of a novel mitochondrial fluorescent nanoprobe based on distyreneanthracene-substituted triphenylphosphonium salt
, Analytical Biochemistry 2021: 114424 (2021)

Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities
, Bioorganic Chemistry 107: 104569 (2020)

Design, synthesis and in vitro anticancer research of novel tetrandrine and fangchinoline derivatives
, Bioorganic Chemistry 109: 104694 (2021)

Design, synthesis and in vitro antitumor evaluation of novel pyrazole-benzimidazole derivatives
, Bioorganic and Medicinal Chemistry Letters 2021: 128097 (2021)

Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol
, Bioorganic Chemistry 114: 105095 (2021)

Design, synthesis and in vivo anticancer activity of novel parthenolide and micheliolide derivatives as NF-κB and STAT3 inhibitors
, Bioorganic Chemistry 111: 104973 (2021)

Design, synthesis and inhibitory activity of novel 2, 3-dihydroquinolin-4(1H)-one derivatives as potential succinate dehydrogenase inhibitors
, European Journal of Medicinal Chemistry 214: 113246 (2021)

Design, synthesis and investigation of the mechanism of action underlying anti-leukemic effects of the quinolinequinones as LY83583 analogs
, Bioorganic Chemistry 114: 105160 (2021)

Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 940-953 (2021)

Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NH-acetamide moieties at C-4
, European Journal of Medicinal Chemistry 206: 112706 (2020)

Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway
, European Journal of Medicinal Chemistry 204: 112658 (2020)

Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)
, European Journal of Medicinal Chemistry 205: 112533 (2020)

Design, synthesis and lipid-lowering activities of penipyridone derivatives
, Bioorganic and Medicinal Chemistry 40: 116192 (2021)

Design, synthesis and mechanistic study of new 1,2,4-triazole derivatives as antimicrobial agents
, Bioorganic Chemistry 111: 104841 (2021)

Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics
, Journal of Antibiotics 70(1): 65-72 (2017)

Design, synthesis and molecular docking of new pyrazole-thiazolidinones as potent anti-inflammatory and analgesic agents with TNF-α inhibitory activity
, Bioorganic Chemistry 111: 104827 (2021)

Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells
, Bioorganic and Medicinal Chemistry 38: 116136 (2021)

Design, synthesis and molecular docking study of α-triazolylsialosides as non-hydrolyzable and potent CD22 ligands
, European Journal of Medicinal Chemistry 208: 112707 (2020)

Design, synthesis and molecular modeling of new quinazolin-4(3H)-one based VEGFR-2 kinase inhibitors for potential anticancer evaluation
, Bioorganic Chemistry 109: 104695 (2021)

Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors
, Bioorganic Chemistry 105: 104439 (2020)

Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity
, Bioorganic Chemistry 103: 104148 (2020)

Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers
, Bioorganic Chemistry 105: 104358 (2020)

Design, synthesis and molecular modeling studies of novel mesalamine linked coumarin for treatment of inflammatory bowel disease
, Bioorganic and Medicinal Chemistry Letters 2021: 128029 (2021)

Design, synthesis and nematicidal activitives of trifluorobutene amide derivatives against Meloidogyne incognita
, Bioorganic and Medicinal Chemistry Letters 2021: 127917 (2021)

Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents
, Bioorganic Chemistry 101: 104010 (2020)

Design, synthesis and pharmacological assessment of new pyrazole compounds
, Inflammopharmacology 28(4): 915-928 (2020)

Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy
, Acta Pharmaceutica Sinica. B 10(8): 1453-1475 (2020)

Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS G12C inhibitors
, European Journal of Medicinal Chemistry 2020: 113082 (2020)

Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular K Ca 1.1 channel stimulators
, Bioorganic Chemistry 105: 104404 (2020)

Design, synthesis and pharmacological evaluation of novel Artemisinin-Thymol
, Natural Product Research 2021: 1-9 (2021)

Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists
, Bioorganic Chemistry 110: 104782 (2021)

Design, synthesis and pharmacological screening of novel renoprotective methionine-based peptidomimetics: Amelioration of cisplatin-induced nephrotoxicity
, Bioorganic Chemistry 114: 105100 (2021)

Design, synthesis and photophysical properties of novel star-shaped truxene-based heterocycles utilizing ring-closing metathesis, Clauson-Kaas, Van Leusen and Ullmann-type reactions as key tools
, Beilstein Journal of Organic Chemistry 17: 1374-1384 (2021)

Design, synthesis and photophysical studies of BODIPY-o, m, p-phenylenediamine-based probes: Insights into their responsiveness under different pH conditions
, Spectrochimica Acta. Part A Molecular and Biomolecular Spectroscopy 262: 120118 (2021)

Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents
, Bioorganic and Medicinal Chemistry Letters 2021: 128269 (2021)

Design, synthesis and screening of benzimidazole containing compounds with methoxylated aryl radicals as cytotoxic molecules on (HCT-116) colon cancer cells
, European Journal of Medicinal Chemistry 2020: 112870 (2020)

Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L
, Bioorganic and Medicinal Chemistry 29: 115827 (2020)

Design, synthesis and structure-activity relationship studies of 4-indole-2-arylaminopyrimidine derivatives as anti-inflammatory agents for acute lung injury
, European Journal of Medicinal Chemistry 225: 113766 (2021)

Design, synthesis and structure-activity relationship studies of novel partial FXR agonists for the treatment of fatty liver
, Bioorganic Chemistry 104: 104262 (2020)

Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer
, European Journal of Medicinal Chemistry 209: 112866 (2020)

Design, synthesis and structure-activity relationship study of piperazinone-containing thieno[3,2-d]pyrimidine derivatives as new PI3Kδ inhibitors
, Bioorganic and Medicinal Chemistry Letters 30(20): 127479 (2020)

Design, synthesis and the structure-activity relationship of agonists targeting on the ALDH2 catalytic tunnel
, Bioorganic Chemistry 104: 104166 (2020)

Design, synthesis biological activity, and docking of novel fluopyram derivatives containing guanidine group
, Bioorganic and Medicinal Chemistry 2020: 115846 (2020)

Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity
, Bioorganic Chemistry 101: 103971 (2020)

Design, synthesis of Cinnamyl-paeonol derivatives with 1, 3-Dioxypropyl as link arm and screening of tyrosinase inhibition activity in vitro
, Bioorganic Chemistry 2020: 104512 (2020)

Design, synthesis of new phenyl acetylene and isoxazole analogues of arjunolic acid as potent tyrosinase and alpha glucosidase inhibitors
, Natural Product Research 2021: 1-6 (2021)

Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus
, Bioorganic and Medicinal Chemistry 28(21): 115729 (2020)

Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1α pathway
, European Journal of Medicinal Chemistry 220: 113474 (2021)

Design, synthesis of pyridine coupled pyrimidinone/pyrimidinthione as anti-MRSA agent: Validation by molecular docking and dynamics simulation
, Journal of Biomolecular Structure and Dynamics 2021: 1-12 (2021)

Design, synthesis, DFT calculations, molecular docking and antimicrobial activities of novel cobalt, chromium metal complexes of heterocyclic moiety-based 1,3,4-oxadiazole derivatives
, Journal of Biomolecular Structure and Dynamics 2021: 1-14 (2021)

Design, synthesis, DNA binding studies and evaluation of anticancer potential of novel substituted biscarbazole derivatives against human glioma U87 MG cell line
, Bioorganic Chemistry 100: 103911 (2020)

Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 1553-1563 (2021)

Design, synthesis, and SAR study of isopropoxy allylbenzene derivatives as 15-lipoxygenase inhibitors
, Iranian Journal of Basic Medical Sciences 23(8): 984-989 (2020)

Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis
, European Journal of Medicinal Chemistry 225: 113743 (2021)

Design, synthesis, and Structure-Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors
, European Journal of Medicinal Chemistry 203: 112552 (2020)

Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 1488-1499 (2021)

Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors
, Bioorganic and Medicinal Chemistry 2020: 115872 (2020)

Design, synthesis, and anti-tumor activities of novel Brevinin-1BYa peptidomimetics
, Bioorganic and Medicinal Chemistry Letters 2021: 127831 (2021)

Design, synthesis, and antibacterial evaluation of PFK-158 derivatives as potent agents against drug-resistant bacteria
, Bioorganic and Medicinal Chemistry Letters 2021: 127980 (2021)

Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV
, Bioorganic Chemistry 112: 104920 (2021)

Design, synthesis, and antibacterial evaluation of novel derivatives of NPS-2143 for the treatment of methicillin-resistant S. aureus (MRSA) infection
, Journal of Antibiotics 72(7): 545-554 (2019)

Design, synthesis, and anticancer activity evaluation of curcumol derivatives
, Journal of Asian Natural Products Research 2021: 1-13 (2021)

Design, synthesis, and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors
, Bioorganic Chemistry 104: 104265 (2020)

Design, synthesis, and anticancer evaluation of novel andrographolide derivatives bearing an α,β-unsaturated ketone moiety
, Bioorganic Chemistry 112: 104941 (2021 )

Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H 3 receptor antagonists/inverse agonists containing triazole moiety
, Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1310-1321 (2020)

Design, synthesis, and antiproliferative effect of 2,9-bis[4-(pyridinylalkylaminomethyl)phenyl]-1,10-phenanthroline derivatives on human leukemic cells by targeting G-quadruplex
, Archiv der Pharmazie 2021: e2000450 (2021)

Design, synthesis, and antitumor activity evaluation of steroidal oximes
, Bioorganic and Medicinal Chemistry 46: 116360 (2021)

Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects
, Bioorganic Chemistry 101: 104019 (2020)

Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors
, Bioorganic and Medicinal Chemistry 32: 116000 (2021)

Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors
, Bioorganic and Medicinal Chemistry 48: 116414 (2021)

Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP
, Bioorganic Chemistry 116: 105353 (2021)

Design, synthesis, and application of a protein A mimetic
, Nature Biotechnology 16(2): 190-195 (1998)

Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase
, Research in Pharmaceutical Sciences 16(5): 482-492 (2021)

Design, synthesis, and bioassay of 4-thiazolinone derivatives as influenza neuraminidase inhibitors
, European Journal of Medicinal Chemistry 213: 113161 (2021)

Design, synthesis, and biodistribution studies of new analogues of marine alkaloids: Potent in vitro and in vivo fungicidal agents against Candida spp
, European Journal of Medicinal Chemistry 210: 113048 (2020)

Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities
, European Journal of Medicinal Chemistry 202: 112519 (2020)

Design, synthesis, and biological activity evaluation of a series of novel sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia
, Bioorganic Chemistry 111: 104849 (2021)

Design, synthesis, and biological activity of novel semicarbazones as potent Ryanodine receptor1 inhibitors of Alzheimer's disease
, Bioorganic and Medicinal Chemistry 29: 115891 (2020)

Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists
, European Journal of Medicinal Chemistry 200: 112410 (2020)

Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-containing pyrazolo[3,4-b]pyridinones as a new series of AMPKɑ1β1γ1 activators
, Archiv der Pharmazie 2021: e2000458 (2021)

Design, synthesis, and biological evaluation of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction
, Bioorganic Chemistry 114: 105034 (2021)

Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities
, European Journal of Medicinal Chemistry 222: 113573 (2021)

Design, synthesis, and biological evaluation of 3-(1-benzotriazole)-nor-β-lapachones as NQO1-directed antitumor agents
, Bioorganic Chemistry 113: 104995 (2021)

Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors
, European Journal of Medicinal Chemistry 215: 113281 (2021)

Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents
, European Journal of Medicinal Chemistry 198: 112396 (2020)

Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1 H -Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 1436-1453 (2021)

Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators
, European Journal of Medicinal Chemistry 204: 112608 (2020)

Design, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation
, Acta Pharmaceutica Sinica. B 11(5): 1315-1328 (2021)

Design, synthesis, and biological evaluation of F-18-labelled 2, 4-diaminopyrimidine-type FAK-targeted inhibitors as potential tumour imaging agents
, Bioorganic and Medicinal Chemistry Letters 30(19): 127452 (2020)

Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors
, European Journal of Medicinal Chemistry 227: 113928 (2021)

Design, synthesis, and biological evaluation of N-(4-substituted)-3-phenylisoxazolo[5,4-d]pyrimidin-4-amine derivatives as apoptosis-inducing cytotoxic agents
, Bioorganic and Medicinal Chemistry Letters 2021: 128294 (2021)

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers
, Bioorganic and Medicinal Chemistry Letters 30(24): 127613 (2020)

Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms
, European Journal of Medicinal Chemistry 218: 113388 (2021)

Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor
, Bioorganic Chemistry 105: 104401 (2020)

Design, synthesis, and biological evaluation of aryl piperazines with potential as antidiabetic agents via the stimulation of glucose uptake and inhibition of NADH:ubiquinone oxidoreductase
, European Journal of Medicinal Chemistry 202: 112416 (2020)

Design, synthesis, and biological evaluation of benzo[d]imidazole-2-carboxamides as new anti-TB agents
, Bioorganic Chemistry 2020: 104538 (2020)

Design, synthesis, and biological evaluation of diosgenin-indole derivatives as dual-functional agents for the treatment of Alzheimer's disease
, European Journal of Medicinal Chemistry 219: 113426 (2021)

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1
, European Journal of Medicinal Chemistry 200: 112338 (2020)

Design, synthesis, and biological evaluation of furosemide analogs as therapeutics for the proteopathy and immunopathy of Alzheimer's disease
, European Journal of Medicinal Chemistry 222: 113565 (2021)

Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity
, European Journal of Medicinal Chemistry 211: 113107 (2020)

Design, synthesis, and biological evaluation of imidazopyridine-linked thiazolidinone as potential anticancer agents
, Archiv der Pharmazie 353(10): e2000071 (2020)

Design, synthesis, and biological evaluation of indazole derivatives as selective and potent FGFR4 inhibitors for the treatment of FGF19-driven hepatocellular cancer
, European Journal of Medicinal Chemistry 214: 113219 (2021)

Design, synthesis, and biological evaluation of indole-based hydroxamic acid derivatives as histone deacetylase inhibitors
, European Journal of Medicinal Chemistry 227: 113893 (2021)

Design, synthesis, and biological evaluation of isoquinolin-1(2 H )-one derivates as tankyrase-1/2 inhibitors
, Die Pharmazie 76(4): 132-137 (2021)

Design, synthesis, and biological evaluation of ligustrazine/resveratrol hybrids as potential anti-ischemic stroke agents
, Chinese Journal of Natural Medicines 18(8): 633-640 (2020)

Design, synthesis, and biological evaluation of multiple targeting antimalarials
, Acta Pharmaceutica Sinica. B 11(9): 2900-2913 (2021)

Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents
, Bioorganic Chemistry 104: 104218 (2020)

Design, synthesis, and biological evaluation of new pyrazoloquinazoline derivatives as dual COX-2/5-LOX inhibitors
, Archiv der Pharmazie 353(11): e2000027 (2020)

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile
, Bioorganic Chemistry 111: 104890 (2021)

Design, synthesis, and biological evaluation of new raloxifene analogues of improved antagonist activity and endometrial safety
, Bioorganic Chemistry 2020: 104482 (2020)

Design, synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors
, Bioorganic Chemistry 2020: 104522 (2020)

Design, synthesis, and biological evaluation of new urolithin amides as multitarget agents against Alzheimer's disease
, Archiv der Pharmazie 2021: e2000467 (2021)

Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation
, European Journal of Medicinal Chemistry 217: 113359 (2021)

Design, synthesis, and biological evaluation of novel 5,6,7-trimethoxy quinolines as potential anticancer agents and tubulin polymerization inhibitors
, Iranian Journal of Basic Medical Sciences 23(12): 1527-1537 (2020)

Design, synthesis, and biological evaluation of novel 6-(pyridin-3-yl) quinazolin-4(3H)-one derivatives as potential anticancer agents via PI3K inhibition
, Bioorganic and Medicinal Chemistry 46: 116346 (2021)

Design, synthesis, and biological evaluation of novel Bcr-Abl T315I inhibitors incorporating amino acids as flexible linker
, Bioorganic and Medicinal Chemistry 48: 116398 (2021)

Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity
, Bioorganic Chemistry 112: 104960 (2021)

Design, synthesis, and biological evaluation of novel FXR agonists based on auraptene
, Bioorganic Chemistry 115: 105198 (2021)

Design, synthesis, and biological evaluation of novel arylcarboxamide derivatives as anti-tubercular agents
, Rsc Advances 10(13): 7523-7540 (2020)

Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor
, Archiv der Pharmazie 2021: e2100080 (2021)

Design, synthesis, and biological evaluation of novel bifunctional thyrointegrin antagonists for neuroblastoma
, Bioorganic and Medicinal Chemistry 42: 116250 (2021)

Design, synthesis, and biological evaluation of novel dual PPARα/δ agonists for the treatment of T2DM
, Bioorganic Chemistry 101: 103963 (2020)

Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer
, European Journal of Medicinal Chemistry 220: 113453 (2021)

Design, synthesis, and biological evaluation of novel imidazole derivatives possessing terminal sulphonamides as potential BRAF V600E inhibitors
, Bioorganic Chemistry 2020: 104508 (2020)

Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents
, European Journal of Medicinal Chemistry 198: 112360 (2020)

Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPARγ and PPARδ
, European Journal of Medicinal Chemistry 159: 267-276 (2018)

Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists
, European Journal of Medicinal Chemistry 226: 113805 (2021)

Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis
, Bioorganic and Medicinal Chemistry 49: 116424 (2021)

Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPARγ with potential anti-diabetic efficacy
, European Journal of Medicinal Chemistry 222: 113542 (2021)

Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives to reduce SREBPs expression for the treatment of hyperlipidemia
, European Journal of Medicinal Chemistry 221: 113522 (2021)

Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease
, European Journal of Medicinal Chemistry 213: 113154 (2021)

Design, synthesis, and biological evaluation of potent 1,2,3,4-tetrahydroisoquinoline derivatives as anticancer agents targeting NF-κB signaling pathway
, Bioorganic and Medicinal Chemistry 46: 116371 (2021)

Design, synthesis, and biological evaluation of pyrazole-linked aloe emodin derivatives as potential anticancer agents
, Rsc Medicinal Chemistry 12(5): 791-796 (2021)

Design, synthesis, and biological evaluation of quinazolin-4(3 H )-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy
, Acta Pharmaceutica Sinica. B 11(1): 156-180 (2021)

Design, synthesis, and biological evaluation of spiroindolines as novel inducers of oligodendrocyte progenitor cell differentiation-Use of a conformation-based hypothesis to facilitate compound design
, Bioorganic and Medicinal Chemistry Letters 30(16): 127299 (2020)

Design, synthesis, and biological evaluation of stapled ascaphin-8 peptides
, Bioorganic and Medicinal Chemistry 40: 116158 (2021 )

Design, synthesis, and biological evaluation of symmetrical azine derivatives as novel tyrosinase inhibitors
, Bmc Chemistry 15(1): 54 (2021)

Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
, European Journal of Medicinal Chemistry 2020: 113004 (2020)

Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain
, Bioorganic Chemistry 101: 103991 (2020)

Design, synthesis, and biological evaluations of novel 3-amino-4-ethynyl indazole derivatives as Bcr-Abl kinase inhibitors with potent cellular antileukemic activity
, European Journal of Medicinal Chemistry 207: 112710 (2020)

Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist
, European Journal of Medicinal Chemistry 211: 113106 (2020)

Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity
, Bioorganic and Medicinal Chemistry Letters 2021: 128306 (2021)

Design, synthesis, and computational validation of novel compounds selectively targeting HER2-expressing breast cancer
, Bioorganic and Medicinal Chemistry Letters 30(24): 127658 (2020)

Design, synthesis, and cytotoxic activity of novel 2H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidine derivatives
, Bioorganic Chemistry 109: 104711 (2021)

Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells)
, Bioorganic Chemistry 101: 103995 (2020)

Design, synthesis, and cytotoxicity screening of new synthesized imidazolidine-2-thiones as VEGFR-2 enzyme inhibitors
, Archiv der Pharmazie 353(11): e2000121 (2020)

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation
, European Journal of Medicinal Chemistry 205: 112669 (2020)

Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B
, Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1513-1523 (2020)

Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer's disease agents
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 1607-1621 (2021)

Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors
, Journal of Venomous Animals and Toxins Including Tropical Diseases 27: E20200066 (2021)

Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions
, Bioorganic Chemistry 116: 105313 (2021)

Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer's disease
, Bioorganic Chemistry 111: 104922 (2021)

Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent
, Bioorganic and Medicinal Chemistry 28(12): 115551 (2020)

Design, synthesis, and evaluation of a novel prodrug, a S-trityl- l -cysteine derivative targeting kinesin spindle protein
, European Journal of Medicinal Chemistry 215: 113288 (2021)

Design, synthesis, and evaluation of amphiphilic sofalcone derivatives as potent Gram-positive antibacterial agents
, European Journal of Medicinal Chemistry 202: 112596 (2020)

Design, synthesis, and evaluation of cytotoxic activities of arylnaphthalene lignans and aza-analogs
, Archiv der Pharmazie 2021: e2000479 (2021)

Design, synthesis, and evaluation of liver-specific gemcitabine prodrugs for potential treatment of hepatitis C virus infection and hepatocellular carcinoma
, European Journal of Medicinal Chemistry 213: 113135 (2021)

Design, synthesis, and evaluation of new 2-oxoquinoline arylaminothiazole derivatives as potential anticancer agents
, Bioorganic Chemistry 2020: 104469 (2020)

Design, synthesis, and evaluation of novel (E)-N'-(3-allyl-2-hydroxy)benzylidene-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as antitumor agents
, Archiv der Pharmazie 2021: e2100216 (2021)

Design, synthesis, and evaluation of novel N' -substituted-1-(4-chlorobenzyl)-1 H -indol-3-carbohydrazides as antitumor agents
, Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1854-1865 (2020)

Design, synthesis, and evaluation of novel coumarin-dithiocarbamate derivatives (IDs) as anti-colorectal cancer agents
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 593-604 (2021)

Design, synthesis, and evaluation of novel l-phenylglycine derivatives as potential PPARγ lead compounds
, Bioorganic and Medicinal Chemistry 26(14): 4153-4167 (2018)

Design, synthesis, and evaluation of novel racecadotril-tetrazole-amino acid derivatives as new potent analgesic agents
, Research in Pharmaceutical Sciences 16(4): 341-357 (2021)

Design, synthesis, and evaluation of peptide-imidazo[1,2-a]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525
, Journal of Peptide Science 2021: e3353 (2021)

Design, synthesis, and evaluation of positron emission tomography/fluorescence dual imaging probes for targeting facilitated glucose transporter 1 (GLUT1)
, Organic and Biomolecular Chemistry 19(14): 3241-3254 (2021)

Design, synthesis, and evaluation of proliferation inhibitory activity of novel L-shaped ortho-quinone analogs as anticancer agents
, Bioorganic Chemistry 117: 105383 (2021)

Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity
, European Journal of Medicinal Chemistry 205: 112537 (2020)

Design, synthesis, and evaluation of substituted 2-acylamide-1,3-benzo[d]zole analogues as agents against MDR- and XDR-MTB
, European Journal of Medicinal Chemistry 2020: 112898 (2020)

Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B
, Bioorganic and Medicinal Chemistry Letters 32: 127723 (2020)

Design, synthesis, and evaluation of transition-state analogs as inhibitors of the bacterial quorum sensing autoinducer synthase CepI
, Bioorganic and Medicinal Chemistry Letters 2021: 127873 (2021)

Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B
, Bioorganic and Medicinal Chemistry Letters 2021: 128265 (2021)

Design, synthesis, and in vitro biological evaluation of novel thiazolopyrimidine derivatives as antileishmanial compounds
, Archiv der Pharmazie 353(8): e1900325 (2020)

Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents
, Bioorganic Chemistry 111: 104895 (2021)

Design, synthesis, and in vitro evaluation of novel triazole analogues featuring isoxazole moieties as antifungal agents
, Bioorganic Chemistry 101: 103982 (2020)

Design, synthesis, and insecticidal activities of propargyloxy-naphthalene-sulfonamide derivatives
, Journal of Asian Natural Products Research 2021: 1-10 (2021)

Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold
, European Journal of Medicinal Chemistry 211: 113083 (2020)

Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition
, Journal of Enzyme Inhibition and Medicinal Chemistry 36(1): 410-424 (2021)

Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors
, Journal of Enzyme Inhibition and Medicinal Chemistry 35(1): 1387-1402 (2020)

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors
, European Journal of Medicinal Chemistry 226: 113848 (2021)

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability
, European Journal of Medicinal Chemistry 227: 113903 (2021)

Design, synthesis, and molecular docking of novel 3,5-disubstituted-1,3,4-oxadiazole derivatives as iNOS inhibitors
, Archiv der Pharmazie 2021: e2000469 (2021)

Design, synthesis, and molecular docking studies of thiazolidinediones as PPAR-γ agonists and thymidylate synthase inhibitors
, Archiv der Pharmazie 2021: e2100021 (2021)

Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors
, Archiv der Pharmazie 353(8): e2000060 (2020)

Design, synthesis, and molecular docking study of novel quinoline-based bis-chalcones as potential antitumor agents
, Archiv der Pharmazie 2021: e2100094 (2021)

Design, synthesis, and molecular docking study of some 2-((7-chloroquinolin-4-yl) amino) benzohydrazide Schiff bases as potential Eg5 inhibitory agents
, Bioorganic Chemistry 116: 105381 (2021)

Design, synthesis, and molecular dynamics simulation studies of quinoline derivatives as protease inhibitors against SARS-CoV-2
, Journal of Biomolecular Structure and Dynamics 2021: 1-24 (2021)

Design, synthesis, and molecular simulation studies of N-phenyltetrahydroquinazolinones as protoporphyrinogen IX oxidase inhibitors
, Bioorganic and Medicinal Chemistry 39: 116165 (2021)