EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Effects of Maternal Deprivation on Anxiety, Depression, and Empathy in Male and Female Offspring of Wistar Rats in the Face of Novel Objects


Effects of Maternal Deprivation on Anxiety, Depression, and Empathy in Male and Female Offspring of Wistar Rats in the Face of Novel Objects



Galen Medical Journal 8: E1093



ISSN/ISBN: 2322-2379

PMID: 34466461

Early life stress (ELS) models such as maternal deprivation (MD) are used to investigate behavioral changes in rodents under stressful situations. MD is a situation in which rat pups are separated from the dam; MD has different paradigms. The purpose of this research is to evaluate the effects of maternal deprivation on anxiety, depression, and empathy in adult Wistar rats. MD was applied to pups as per specifically designed protocol to compare rats of the control group with maternal deprivation rats and also the group, which faced novel objects. Each group consisted of eight rats. In this study, separation started from postnatal day (PND) 14 for various periods up to PND 60. EPM test was undertaken to measure anxiety; moreover, FST was used to indicate levels of depression. Also, changes in the empathy ratio were also demonstrated. One-way analysis of variance (ANOVA), Tukey's post hoc analysis, and t-test were applied to analyze the results. MD-treated rats showed a significant decrease in anxiety and empathy indexes compared with those in the control group (P<0.05). However, MD significantly increased depression in both male and female rats (P<0.05). Finally, exposure to novel objects decreased depression but did not have any effect on anxiety and empathy levels in MD rats (P<0.05). ELS may lead to various states of mood and behavior in adulthood. According to the findings of this study, depression increases due to MD, though both anxiety and empathy decrease in both male and female Wistar rats. Moreover, exposure to novel objects decreases depression, while anxiety and empathy do not change significantly with exposure to novel objects.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 071665355

Download citation: RISBibTeXText

Related references

Effects of lipopolysaccharide administration and maternal deprivation on anxiety and depressive symptoms in male and female Wistar rats: Neurobehavioral and biochemical assessments. Behavioural Brain Research 362: 46-55, 2019

Maternal exposure to Bonny Light Crude Oil Altered Reproductive indices in Male and Female offspring of Wistar rats. Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria 36(1): 49-55, 2021

Transgenerational influence of parental morphine exposure on pain perception, anxiety-like behavior and passive avoidance memory among male and female offspring of Wistar rats. Excli Journal 18: 1019-1036, 2019

Effects of maternal hypothyroidism in the gastrointestinal system of male young offspring from Wistar rats. Journal of Developmental Origins of Health and Disease 12(2): 286-292, 2021

Effects of Oral Maternal Administration of Caffeine on Reproductive Functions of Male Offspring of Wistar Rats. Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria 30(1-2): 51-58, 2015

Maternal high fat feeding does not have long-lasting effects on body composition and bone health in female and male Wistar rat offspring at young adulthood. Molecules 18(12): 15094-15109, 2013

Fluoxetine normalizes the effects of prenatal maternal stress on depression- and anxiety-like behaviors in mouse dams and male offspring. Behavioural Brain Research 311: 354-367, 2016

Effects of early weaning on anxiety and prefrontal cortical and hippocampal myelination in male and female Wistar rats. Developmental Psychobiology 50(4): 332-342, 2008

Maternal Deprivation Increases Anxiety- and Depressive-Like Behaviors in an Age-Dependent Fashion and Reduces Neuropeptide Y Expression in the Amygdala and Hippocampus of Male and Female Young Adult Rats. Frontiers in Behavioral Neuroscience 12: 159, 2018

Effects of maternal deprivation on melatonin production and cognition in adolescent male and female rats. Neuro Endocrinology Letters 26(5): 555-560, 2005

Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. Plos one 4(1): E3675, 2009

Maternal deprivation effects on brain plasticity and recognition memory in adolescent male and female rats. Neuropharmacology 68: 223-231, 2013

Predation threat exerts specific effects on rat maternal behaviour and anxiety-related behaviour of male and female offspring. Physiology and Behavior 96(4-5): 693-702, 2009

Interaction of lithium and sleep deprivation on memory performance and anxiety-like behavior in male Wistar rats. Behavioural Brain Research 428: 113890, 2022

Older maternal age is associated with depression, anxiety, and stress symptoms in young adult female offspring. Journal of Abnormal Psychology 125(1): 1-10, 2016