Section 72
Chapter 71,700

Endothelin stimulates PDGF secretion in cultured human mesangial cells

Jaffer, F.E.; Knauss, T.C.; Poptic, E.; Abboud, H.E.

Kidney International 38(6): 1193-1198


ISSN/ISBN: 0085-2538
PMID: 2074661
DOI: 10.1038/ki.1990.333
Accession: 071699311

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Endothelin, a 17-DKa peptide originally described as a potent vasoconstrictor, also stimulates the release of important regulators of glomerular hemodynamics such as atrial natriuretic factor and renin. In the present study we investigated the role of endothelin in the release of another potent vasoconstrictor and mitogen of human mesangial cells, the platelet-derived growth factor. Endothelin stimulated PDGF release at 12 hours and the effect was sustained for 36 hours. This effect was associated with the enhanced induction of mRNAs encoding PDGF A- and B-chain. Endothelin also induced mitogenesis in human mesangial cells which was accompanied by activation of phospholipase C with increased inositol phosphate turnover. These data suggest a mechanism by which endothelin may regulate mesangial cell function in disease states.

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