High-flow nasal cannula oxygen therapy to treat patients with hypoxemic acute respiratory failure consequent to SARS-CoV-2 infection

Vianello, A.; Arcaro, G.; Molena, B.; Turato, C.; Sukthi, A.; Guarnieri, G.; Lugato, F.; Senna, G.; Navalesi, P.

Thorax 75(11): 998-1000

2020


ISSN/ISBN: 1468-3296
PMID: 32703883
DOI: 10.1136/thoraxjnl-2020-214993
Accession: 071877966

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Abstract
This observational study aims to assess the outcome and safety of O2-therapy by high-flow nasal cannula (HFNC) in 28 consecutive patients with severe hypoxemic acute respiratory failure (hARF) consequent to SARS-CoV-2 infection, unresponsive to conventional O2-therapy. Nineteen patients had a positive response. Nine patients required escalation of treatment to non-invasive ventilation (five subsequently intubated). None of the staff had a positive swab testing during the study period and the following 14 days. Severity of hypoxemia and C reactive protein level were correlated with HFNC failure. These data suggest HFNC to be a safe treatment for less severe patients with SARS-CoV-2 hARF and efficacy will need to be assessed as part of a clinical trial.