Level of Coagulation Function Indexes and its Clinical Significance in Patients with Lymphoplasmacytic Lymphoma
Liang, X.-P.; Wang, H.-D.; Shao, M.-M.; Li, N.; Han, W.-X.
Zhongguo Shi Yan Xue Ye Xue Za Zhi 28(4): 1205-1209
To analyze the level of coagulation function indexes in patients with lymphoplasmacytic lymphoma (LPL) and its clinical significance. The clinical data of 32 patients with initial LPL (LPL group) and physical examination data of 25 healthy persons (control group) who underwent physical examination in our hospital during the same period were collected. The differences of platelet (Plt), D-Dimer (D-D), fibrinogen (Fib), thrombin time (TT), prothrombin time (PT) and activated partial thrombin time (APTT) between the two groups were compared. The Plt count in LPL group [ (137.06±40.14)×109/L] was significantly lower than that in control group [ (215.07±33.25)×109/L], D-D [ (1.01±0.16) mg/L, PT [ (13.01±1.37) s] and APTT [ (40.96±7.24) s] in LPL group were significantly higher than those in control group [ (0.37±0.09) mg/L, (11.96±0.87) s, (25.07±5.13) s] (P＜0.01); there was no significant difference in TT and Fib levels between the two groups (P＞0.05). There was no significant difference in Plt, D-D, Fib, AP, TT and APTT among LPL patients secreting different types of immunoglobulin (Ig) (P＞0.05). After treatment, the coagulation function of LPL patients returned to normal, and no death cases occurred due to hemorrhage or thrombosis. LPL patients have hypercoagulable state blood and abnormal coagulation function, but which not closely relates to with the type of Ig secreted by patients. 淋巴浆细胞样淋巴瘤患者凝血功能指标水平及其临床意义. 分析淋巴浆细胞样淋巴瘤（lymphoplasmacytic lymphoma，LPL）患者凝血功能指标水平及其临床意义. 收集本院32例初发LPL患者（LPL病例组）的临床资料，另同期收集25例于本院体检健康的人员（对照组）的资料。比较2组凝血功能指标血小板（Plt）、D-二聚体（D-D）、纤维蛋白原（Fib）、凝血酶时间（TT）、凝血酶原时间（PT）和活化部分凝血酶原时间（APTT）等的差异. LPL组Plt [ (137.06±40.14)×109/L]较对照组[ (215.07±33.25)×109/L]显著下降，D-D [ (1.01±0.16) mg/L]、PT [ (13.01±1.37) s]和APTT [ (40.96±7.24) s]较对照组[ (0.37±0.09) mg/L、(11.96±0.87) s、(25.07±5.13) s]显著升高（P＜0.01）；2组TT和Fib水平的比较，并无显著性差异（P＞0.05）。分泌不同免疫球蛋白（Ig）类型的LPL患者Plt、D-D、Fib、AP、TT及APTT与对照组比较，并无显著性差异（P＞0.05）。LPL患者经治疗后，凝血功能恢复正常，且未出现因出血、血栓形成而死亡的病例. LPL患者体内存在血液高凝状态，出现凝血功能异常，且这与患者分泌的Ig类型并无密切关系.