MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment

Zhang, L.; Sankaran, V.G.; Lodish, H.F.

Leukemia 26(11): 2310-2316

2012


ISSN/ISBN: 0887-6924
PMID: 22617791
DOI: 10.1038/leu.2012.137
Accession: 072128897

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Abstract
MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that modulate the expression of their target genes through either mRNA degradation or inhibition of protein translation. In recent years, miRNAs have been shown to be critical regulators of hematopoiesis and have important roles in the differentiation of specific lineages. Here, we summarize our current understanding of miRNAs involved in hematopoiesis with a focus on the role of miRNAs in regulating erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment.