Overhydration and low serum prealbumin predict peritoneal dialysis-related peritonitis in continuous ambulatory peritoneal dialysis patients

Dao Bui Quy, Q.; Pham Ngoc Huy, T.; Nguyen Duc, L.; Pham Van, M.; Nguyen Huu, D.; Nguyen Duy, T.; Tran Viet, T.; Do, Q.; Le Viet, T.

Bmc Nephrology 21(1): 512


ISSN/ISBN: 1471-2369
PMID: 33238904
DOI: 10.1186/s12882-020-02178-w
Accession: 072265925

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In this study, we focused on the role of overhydration (OH) and low serum prealbumin concentration in predicting peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients over a 3-year period. We measured serum prealbumin concentration and OH by body composition monitor in 278 CAPD patients (159 males and 119 females) with a mean age of 46 years and a median peritoneal dialysis (PD) duration of 21 months. Cases of PD-related peritonitis were collected over 3 years. After the 3-year follow-up, 44 patients were diagnosed with PD-related peritonitis (15.8%). Low education, serum glucose, prealbumin, and OH were independent risk factors for predicting peritonitis over 36 months in CAPD patients. Based on the ROC curve model and Kaplan-Meier analysis, we realized that low prealbumin and high OH were independent predictors of 3-year peritonitis in CAPD patients (Prealbumin: AUC = 0.838, cut-off value = 32.5 mg/dL, Se = 90.9%, Sp = 32.9%; OH: AUC = 0.851, cut-off value = 1.33 L, Se = 79.5%, Sp = 85.5%; and log-rank test p <  0.001, respectively). Overhydration and low serum prealbumin were the independent predictors of PD-related peritonitis in CAPD patients.