+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Parasite-specific immune response in adult Drosophila melanogaster: a genomic study

Parasite-specific immune response in adult Drosophila melanogaster: a genomic study

Embo Reports 5(2): 207-212

ISSN/ISBN: 1469-221X

PMID: 14749722

DOI: 10.1038/sj.embor.7400073

Insects of the order Diptera are vectors for parasitic diseases such as malaria, sleeping sickness and leishmania. In the search for genes encoding proteins involved in the antiparasitic response, we have used the protozoan parasite Octosporea muscaedomesticae for oral infections of adult Drosophila melanogaster. To identify parasite-specific response molecules, other flies were exposed to virus, bacteria or fungi in parallel. Analysis of gene expression patterns after 24 h of microbial challenge, using Affymetrix oligonucleotide microarrays, revealed a high degree of microbe specificity. Many serine proteases, key intermediates in the induction of insect immune responses, were uniquely expressed following infection of the different organisms. Several lysozyme genes were induced in response to Octosporea infection, while in other treatments they were not induced or downregulated. This suggests that lysozymes are important in antiparasitic defence.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 072279935

Download citation: RISBibTeXText

Related references

Immune response of Drosophila melanogaster to infection with the flagellate parasite Crithidia spp. Insect Biochemistry and Molecular Biology 31(2): 129-137, 2001

Age-specific variation in immune response in Drosophila melanogaster has a genetic basis. Genetics 191(3): 989-1002, 2012

Naturally occurring genetic variation in the age-specific immune response of Drosophila melanogaster. Aging Cell 5(4): 293-295, 2006

Sex-specific variation in the emphasis, inducibility and timing of the post-mating immune response in Drosophila melanogaster. Proceedings. Biological Sciences 276(1659): 1109-1117, 2009

Sex-Specific Variation in the Emphasis, Inducibility and Timing of the Post-Mating Immune Response in Drosophila melanogaster. Proceedings: Biological Sciences 276(1659): 1109-1117, 2009

Fungal peptide Destruxin a plays a specific role in suppressing the innate immune response in Drosophila melanogaster. Journal of Biological Chemistry 282(12): 8969-8977, 2007

The Effects of Parasite-Derived Immune-Suppressive Factors on the Cellular Innate Immune and Autoimmune Responses of Drosophila melanogaster. The Journal of Parasitology 90(5): 1139-1149, 2004

The effects of parasite-derived immune-suppressive factors on the cellular innate immune and autoimmune responses of Drosophila melanogaster. Journal of Parasitology 90(5): 1139-1149, 2004

Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster. Dna and Cell Biology 29(9): 473-485, 2010

Genomic imprinting absent in Drosophila melanogaster adult females. Cell Reports 2(1): 69-75, 2012

Identification of methylated sequences in genomic DNA of adult Drosophila melanogaster. Biochemical and Biophysical Research Communications 322(2): 465-469, 2004

Identification of a regulatory allele of teashirt (tsh) in Drosophila melanogaster that affects wing hinge development. An adult-specific tsh enhancer in Drosophila. Mechanisms of Development 105(1-2): 145-151, 2001

Immune-deficient Drosophila melanogaster: a model for the innate immune response to human fungal pathogens. Journal of Immunology 172(9): 5622-5628, 2004

Parasite-induced enhancement of hemolymph tyrosinase activity in a selected immune reactive strain of Drosophila melanogaster. Archives of Insect Biochemistry and Physiology 18(3): 159-168, 1991

Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster. Philosophical Transactions of the Royal Society of London. Series B Biological Sciences 375(1795): 20190341, 2020