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Parasitemia Evaluation in Mice Infected with Schistosoma mansoni


Parasitemia Evaluation in Mice Infected with Schistosoma mansoni



Bio-Protocol11(10):E4017



ISSN/ISBN: 2331-8325

PMID: 34150924

Schistosomiasis is a neglected tropical disease. Its treatment relies on the use of a single drug, praziquantel. Due to treatment limitations, an alternative for schistosomiasis chemotherapy is required; thus, a better understanding of parasite biology and host-parasite interactions is valuable to aid the identification of new anti-Schistosoma drugs. The parasite has a complex life cycle, which results in challenges regarding the evaluation of Schistosoma mansoni development and mammalian infection establishment. Accordingly, this protocol describes methodologies to evaluate: (1) adult worm growth; (2) reproduction; and (3) granuloma formation; and consequently allows more comprehensive knowledge of S. mansoni development in a natural biological system.

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Accession: 072279937

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