Section 73

EurekaMag Full Text Articles Chapter 72,638


Matsumae, G.; Shimizu, T.; Tian, Y.; Takahashi, D.; Ebata, T.; Alhasan, H.; Yokota, S.; Kadoya, K.; Terkawi, M.A.; Iwasaki, N. 2021: Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis. Bioengineering and Translational Medicine 6(3): E10232
Sperotto, N.D.d.M.; Silva, R.B.M.; Perelló, M.A.; Borsoi, A.F.áv.; da Silva Dadda, A.; Roth, C.D.; Freitas, R.D.S.; de Souza, A.P.D.; Freitas, D.d.N.d.; Picada, J.N.; de Sousa, J.T.; Nabinger, D.éb.D.; Altenhofen, S.; Bonan, C.D.; Rodrigues-Junior, V.ês.S.; Bizarro, C.V.; Basso, L.A.; Machado, P. 2021: Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts. Biomedicine and PharmacoTherapy 139: 111672
Leserman, L.D.; Barbet, J.; Kourilsky, F.; Weinstein, J.N. 1980: Targeting to cells of fluorescent liposomes covalently coupled with monoclonal antibody or protein A. Nature 288(5791): 602-604
Hoppe, H.C.; Ngô, H.M.; Yang, M.; Joiner, K.A. 2000: Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms. Nature Cell Biology 2(7): 449-456
Zeng, W.; Zhang, C.; Cheng, H.; Wu, Y-Long.; Liu, J.; Chen, Z.; Huang, J-Gang.; Ericksen, R.Erick.; Chen, L.; Zhang, H.; Wong, A.Sze.Tsai.; Zhang, X-Kun.; Han, W.; Zeng, J-Zhang. 2017: Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma. Scientific Reports 7(1): 348
La Spada, A.R.; Weydt, P. 2005: Targeting toxic proteins for turnover. Nature Medicine 11(10): 1052-1053
Bushweller, J.H. 2019: Targeting transcription factors in cancer - from undruggable to reality. Nature Reviews. Cancer 19(11): 611-624
Mapp, A.K.; Pricer, R.; Sturlis, S. 2015: Targeting transcription is no longer a quixotic quest. Nature Chemical Biology 11(12): 891-894
Floros, K.V.; Jacob, S.; Kurupi, R.; Fairchild, C.K.; Hu, B.; Puchalapalli, M.; E Koblinski, J.; Dozmorov, M.G.; Boikos, S.A.; Scaltriti, M.; Faber, A.C. 2021: Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors. Cell Death and Disease 12(2): 179
Kwiatkowski, N.; Zhang, T.; Rahl, P.B.; Abraham, B.J.; Reddy, J.; Ficarro, S.B.; Dastur, A.; Amzallag, A.; Ramaswamy, S.; Tesar, B.; Jenkins, C.E.; Hannett, N.M.; McMillin, D.; Sanda, T.; Sim, T.; Kim, N.Doo.; Look, T.; Mitsiades, C.S.; Weng, A.P.; Brown, J.R.; Benes, C.H.; Marto, J.A.; Young, R.A.; Gray, N.S. 2014: Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature 511(7511): 616-620
Lohmann, G.; Vasyutina, E.; Bloehdorn, J.; Reinart, N.; Schneider, J.I.; Babu, V.; Knittel, G.; Crispatzu, G.; Mayer, P.; Prinz, C.; Muenzner, J.K.; Biersack, B.; Efremov, D.G.; Chessa, L.; Herling, C.D.; Stilgenbauer, S.; Hallek, M.; Schobert, R.; Reinhardt, H.C.; Schumacher, B.; Herling, M. 2017: Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia. Leukemia 31(5): 1177-1186
Johnsen, K.Bendix.; Burkhart, A.; Melander, F.; Kempen, P.Joseph.; Vejlebo, J.Bruun.; Siupka, P.; Nielsen, M.Schallburg.; Andresen, T.Lars.; Moos, T. 2017: Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma. Scientific Reports 7(1): 10396
Chen, J.; Ding, Z.-Y.; Li, S.; Liu, S.; Xiao, C.; Li, Z.; Zhang, B.-X.; Chen, X.-P.; Yang, X. 2021: Targeting transforming growth factor-β signaling for enhanced cancer chemotherapy. Theranostics 11(3): 1345-1363
Zhang, J.; Jasutkar, H.G.; Mouradian, M.M. 2021: Targeting transglutaminase 2 as a potential disease modifying therapeutic strategy for synucleinopathies. Neural Regeneration Research 16(8): 1560-1561
Nayak, S.; Calvo, J.A.; Cantor, S.B. 2021: Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability. Expert Opinion on Therapeutic Targets 2021: 1-10
Yates, D. 2020: Targeting transport in CNS oedema. Nature Reviews. Neuroscience 21(7): 350-351
Miller, D.R.; Ingersoll, M.A.; Teply, B.A.; Lin, M.-F. 2021: Targeting treatment options for castration-resistant prostate cancer. American Journal of Clinical and Experimental Urology 9(1): 101-120
Chou, Y.-T.; Lin, C.-Y.; Wen, J.-W.; Hung, L.-C.; Chang, Y.-F.; Yang, C.-M.; Wu, L.-C.; Ho, J.-A.A. 2021: Targeting triple-negative breast cancer with an aptamer-functionalized nanoformulation: a synergistic treatment that combines photodynamic and bioreductive therapies. Journal of Nanobiotechnology 19(1): 89
Gelmon, K.; Dent, R.; Mackey, J.R.; Laing, K.; McLeod, D.; Verma, S. 2012: Targeting triple-negative breast cancer: optimising therapeutic outcomes. Annals of Oncology: Official Journal of the European Society for Medical Oncology 23(9): 2223-2234
Lalaoui, N.; Merino, D.; Giner, G.; Vaillant, Fçois.; Chau, D.; Liu, L.; Kratina, T.; Pal, B.; Whittle, J.R.; Etemadi, N.; Berthelet, J.; Gräsel, J.; Hall, C.; Ritchie, M.E.; Ernst, M.; Smyth, G.K.; Vaux, D.L.; Visvader, J.E.; Lindeman, G.J.; Silke, J. 2020: Targeting triple-negative breast cancers with the Smac-mimetic birinapant. Cell Death and Differentiation 27(10): 2768-2780
Ray, A.; Song, Y.; Du, T.; Tai, Y-Tzu.; Chauhan, D.; Anderson, K.C. 2020: Targeting tryptophan catabolic kynurenine pathway enhances antitumor immunity and cytotoxicity in multiple myeloma. Leukemia 34(2): 567-577
Clendening, J.W.; Penn, L.Z. 2012: Targeting tumor cell metabolism with statins. Oncogene 31(48): 4967-4978
Feng, H.; Liu, K.; Shen, X.; Liang, J.; Wang, C.; Qiu, W.; Cheng, X.; Zhao, R. 2020: Targeting tumor cell-derived CCL2 as a strategy to overcome Bevacizumab resistance in ETV5 + colorectal cancer. Cell Death and Disease 11(10): 916
Guo, H.; Zhang, J.; Inal, C.; Nguyen, T.; Fruehauf, J.H.; Keates, A.C.; Li, C.J. 2011: Targeting tumor gene by shRNA-expressing Salmonella-mediated RNAi. Gene Therapy 18(1): 95-105
Mudassar, F.; Shen, H.; O'Neill, G.; Hau, E. 2020: Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas. Journal of Experimental and Clinical Cancer Research: Cr 39(1): 208
Lin, Z.; Xiang, X.; Lu, D.; Xu, X. 2020: Targeting tumor microenvironment as a treatment strategy for hepatocellular carcinoma. Hepatobiliary Surgery and Nutrition 9(6): 794-796
Woolf, N.; Pearson, B.E.; Bondzie, P.A.; Meyer, R.D.; Lavaei, M.; Belkina, A.C.; Chitalia, V.; Rahimi, N. 2017: Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy. Oncogenesis 6(9): E378
Gerard, L.; Duvivier, L.; Gillet, J.-P. 2021: Targeting tumor resistance mechanisms. Faculty Reviews 10: 6
Breitbach, C.J.; De Silva, N.S.; Falls, T.J.; Aladl, U.; Evgin, L.; Paterson, J.; Sun, Y.Yang.; Roy, D.G.; Rintoul, J.L.; Daneshmand, M.; Parato, K.; Stanford, M.M.; Lichty, B.D.; Fenster, A.; Kirn, D.; Atkins, H.; Bell, J.C. 2011: Targeting tumor vasculature with an oncolytic virus. Molecular Therapy: the Journal of the American Society of Gene Therapy 19(5): 886-894
Rendo, V.; Stoimenov, I.; Sjöblom, T. 2020: Targeting tumor vulnerabilities associated with loss of heterozygosity. Molecular and Cellular Oncology 7(4): 1759390
Loeuillard, E.; Yang, J.; Buckarma, E.; Wang, J.; Liu, Y.; Conboy, C.; Pavelko, K.D.; Li, Y.; O'Brien, D.; Wang, C.; Graham, R.P.; Smoot, R.L.; Dong, H.; Ilyas, S. 2020: Targeting tumor-associated macrophages and granulocytic myeloid-derived suppressor cells augments PD-1 blockade in cholangiocarcinoma. Journal of Clinical Investigation 130(10): 5380-5396
Gazzaniga, S.; Bravo, A.I.; Guglielmotti, A.; van Rooijen, N.; Maschi, F.; Vecchi, A.; Mantovani, A.; Mordoh, Jé.; Wainstok, R. 2007: Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft. Journal of Investigative Dermatology 127(8): 2031-2041
Cheng, N.; Bai, X.; Shu, Y.; Ahmad, O.; Shen, P. 2021: Targeting tumor-associated macrophages as an antitumor strategy. Biochemical Pharmacology 183: 114354
Shu, Y.; Cheng, P. 2020: Targeting tumor-associated macrophages for cancer immunotherapy. Biochimica et Biophysica Acta. Reviews on Cancer 1874(2): 188434
Zhou, K.; Cheng, T.; Zhan, J.; Peng, X.; Zhang, Y.; Wen, J.; Chen, X.; Ying, M. 2020: Targeting tumor-associated macrophages in the tumor microenvironment. Oncology Letters 20(5): 234
Xiang, X.; Wang, J.; Lu, D.; Xu, X. 2021: Targeting tumor-associated macrophages to synergize tumor immunotherapy. Signal Transduction and Targeted Therapy 6(1): 75
Rampias, T.; Favicchio, R.; Stebbing, J.; Giamas, G. 2016: Targeting tumor-stroma crosstalk: the example of the NT157 inhibitor. Oncogene 35(20): 2562-2564
Ratcliffe, P.J.; Pugh, C.W.; Maxwell, P.H. 2000: Targeting tumors through the HIF system. Nature Medicine 6(12): 1315-1316
Golding, J.P.; Wardhaugh, T.; Patrick, L.; Turner, M.; Phillips, J.B.; Bruce, J.I.; Kimani, S.G. 2013: Targeting tumour energy metabolism potentiates the cytotoxicity of 5-aminolevulinic acid photodynamic therapy. British Journal of Cancer 109(4): 976-982
Dobbelstein, M.; Moll, U. 2014: Targeting tumour-supportive cellular machineries in anticancer drug development. Nature Reviews. Drug Discovery 13(3): 179-196
Sadelain, M.; Rivière, I.; Brentjens, R. 2003: Targeting tumours with genetically enhanced T lymphocytes. Nature Reviews. Cancer 3(1): 35-45
Greenhill, C. 2018: Targeting two pathways to treat obesity and T2DM. Nature Reviews. Endocrinology 15(1): 4
Chen, C.; Wang, X.; Xiong, X.; Liu, Q.; Huang, Y.; Xu, Q.; Hu, J.; Ge, G.; Ling, K. 2015: Targeting type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasis. Oncogene 34(35): 4635-4646
Zhou, X.; Sun, S-Cong. 2021: Targeting ubiquitin signaling for cancer immunotherapy. Signal Transduction and Targeted Therapy 6(1): 16
Khanna, M.; Agrawal, N.; Chandra, R.; Dhawan, G. 2021: Targeting unfolded protein response: a new horizon for disease control. Expert Reviews in Molecular Medicine 23: E1
Ton, J.; Kolber, M.R. 2020: Targeting uric acid levels in treating gout. Canadian Family Physician Medecin de Famille Canadien 66(9): 671
Chung, S.H.; Frick, S.L.; Yiu, G. 2021: Targeting vascular endothelial growth factor using retinal gene therapy. Annals of Translational Medicine 9(15): 1277
Huchting, J. 2020: Targeting viral genome synthesis as broad-spectrum approach against RNA virus infections. Antiviral Chemistry and ChemoTherapy 28: 2040206620976786
Clatworthy, A.E.; Pierson, E.; Hung, D.T. 2007: Targeting virulence: a new paradigm for antimicrobial therapy. Nature Chemical Biology 3(9): 541-548
Allen, R.C.; Popat, R.; Diggle, S.P.; Brown, S.P. 2014: Targeting virulence: can we make evolution-proof drugs?. Nature Reviews. Microbiology 12(4): 300-308
Peng, K-W.; Holler, P.D.; Orr, B.A.; Kranz, D.M.; Russell, S.J. 2004: Targeting virus entry and membrane fusion through specific peptide/MHC complexes using a high-affinity T-cell receptor. Gene Therapy 11(15): 1234-1239
Zamponi, G.W. 2016: Targeting voltage-gated calcium channels in neurological and psychiatric diseases. Nature Reviews. Drug Discovery 15(1): 19-34
Groeneveld, D.J.; Poole, L.G.; Luyendyk, J.P. 2021: Targeting von Willebrand factor in liver diseases: a novel therapeutic strategy?. Journal of Thrombosis and Haemostasis: Jth 19(6): 1390-1408
Z Papadakis, G.; Kochiadakis, G.; Lazopoulos, G.; Marias, K.; Klapsinos, N.; Hannah-Shmouni, F.; G Igoumenaki, G.; Konstantinos Nikolouzakis, T.; Kteniadakis, S.; A Spandidos, D.; H Karantanas, A. 2020: Targeting vulnerable atherosclerotic plaque via PET-tracers aiming at cell-surface overexpression of somatostatin receptors. Biomedical Reports 13(3): 9
Wang, N.; Xu, J.; Ma, M.; Shan, L.; Jiao, M.; Xia, Q.; Tian, W.; Zhang, X.; Liu, L.; Hao, Y.; Gao, L.; Wu, Q.; Li, Y. 2020: Targeting vulnerable groups of health poverty alleviation in rural China- what is the role of the new Rural Cooperative Medical Scheme for the middle age and elderly population?. International Journal for Equity in Health 19(1): 161
Wong, G.S.; Zhou, J.; Liu, J.Bin.; Wu, Z.; Xu, X.; Li, T.; Xu, D.; Schumacher, S.E.; Puschhof, J.; McFarland, J.; Zou, C.; Dulak, A.; Henderson, L.; Xu, P.; O'Day, E.; Rendak, R.; Liao, W-Li.; Cecchi, F.; Hembrough, T.; Schwartz, S.; Szeto, C.; Rustgi, A.K.; Wong, K-Kin.; Diehl, J.Alan.; Jensen, K.; Graziano, F.; Ruzzo, A.; Fereshetian, S.; Mertins, P.; Carr, S.A.; Beroukhim, R.; Nakamura, K.; Oki, E.; Watanabe, M.; Baba, H.; Imamura, Y.; Catenacci, D.; Bass, A.J. 2018: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nature Medicine 24(7): 968-977
Holzhauer, C.G.; Epstein, E.E.; Smelson, D.A.; Mattocks, K. 2021: Targeting women veteran's stress-induced drinking with cognitive reappraisal: Mechanisms and moderators of change. Journal of Substance Abuse Treatment 130: 108408
Kwatra, S.G. 2011: Targeting x-linked inhibitor of apoptosis protein for melanoma therapy: the need for more homogeneous samples and the importance of cell lines. Journal of Investigative Dermatology 131(3): 797
Doboszewska, U.; Wlaź, P.; Nowak, G.; Młyniec, K. 2020: Targeting zinc metalloenzymes in coronavirus disease 2019. British journal of pharmacology 177(21): 4887-4898
Lemos, M.; Venezia, S.; Refolo, V.; Heras-Garvin, A.; Schmidhuber, S.; Giese, A.; Leonov, A.; Ryazanov, S.; Griesinger, C.; Galabova, G.; Staffler, G.; Wenning, G.K.; Stefanova, N. 2020: Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance. Translational Neurodegeneration 9(1): 38
Byrareddy, S.N.; Kallam, B.; Arthos, J.; Cicala, C.; Nawaz, F.; Hiatt, J.; Kersh, E.N.; McNicholl, J.M.; Hanson, D.; Reimann, K.A.; Brameier, M.; Walter, L.; Rogers, K.; Mayne, A.E.; Dunbar, P.; Villinger, T.; Little, D.; Parslow, T.G.; Santangelo, P.J.; Villinger, F.; Fauci, A.S.; Ansari, A.A. 2014: Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection. Nature Medicine 20(12): 1397-1400
Moon, J-Hee.; Hong, S-Woo.; Kim, J.Eun.; Shin, J-Sik.; Kim, J-Sun.; Jung, S-A.; Ha, S.Hee.; Lee, S.; Kim, J.; Lee, D.Hee.; Park, Y.Sun.; Kim, D.Min.; Park, S-Soo.; Hong, J.Ki.; Kim, D.Yeon.; Kim, E.Ho.; Jung, J.; Kim, M.Jin.; Kim, S-Mi.; Deming, D.A.; Kim, K.; Kim, T.Won.; Jin, D-Hoon. 2019: Targeting β-catenin overcomes MEK inhibition resistance in colon cancer with KRAS and PIK3CA mutations. British Journal of Cancer 120(9): 941-951
Jiang, X.; Cao, Y.; Li, F.; Su, Y.; Li, Y.; Peng, Y.; Cheng, Y.; Zhang, C.; Wang, W.; Ning, G. 2014: Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours. Nature Communications 5: 5809
Starling, S. 2019: Targeting β-cell senescence. Nature Reviews. Endocrinology 15(8): 438-439
Lin, Y-F.; Lee, Y-F.; Liang, P-H. 2012: Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation. Cell Death and Disease 3: E434
Rozo, M.; Li, L.; Fan, C-Ming. 2016: Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice. Nature Medicine 22(8): 889-896
Sibarita, J-Baptiste.; Heilemann, M. 2012: Targeting, resolving and quantifying cellular structures by single-molecule localization microscopy. Embo Reports 13(12): 1043-1045
Feng, X.-D. 2021: Targeting-YAP/TAZ therapies for head and neck cancer, directly or indirectly?. Hua Xi Kou Qiang Yi Xue Za Zhi 39(5): 493-500
Ahmed, A.; Werbel, T.; De Benedetto, A.; Motaparthi, K. 2021: Targetoid clinical morphology as a diagnostic clue of the lichenoid histopathologic subtype of pigmented purpuric dermatosis. Jaad Case Reports 13: 81-85
Faraji, M.; Gutierrez, E.; Glotser, A.; Thaker, J.; Gammarano, C. 2020: Targets and Combs: a Case of Lupus Enteritis. Cureus 12(4): E7892
Liu, Y.; An, T.; Wan, D.; Yu, B.; Fan, Y.; Pei, X. 2020: Targets and Mechanism Used by Cinnamaldehyde, the Main Active Ingredient in Cinnamon, in the Treatment of Breast Cancer. Frontiers in Pharmacology 11: 582719
Veluthambi, K.; Sunitha, S. 2021: Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2. Frontiers in Microbiology 12: 645419
Bostan, M.; Ataman, M.; Bostan, I.Stefania.; Bleotu, C. 2020: Targets and assay types for COVID-19 diagnosis. Journal of Immunoassay and Immunochemistry 41(6): 946-959
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Yang, Y.; Zhang, J-Liang.; Zhou, Q. 2020: Targets and mechanisms of dietary anthocyanins to combat hyperglycemia and hyperuricemia: a comprehensive review. Critical Reviews in Food Science and Nutrition 2020: 1-25
Malik, J.A.; Mulla, A.H.; Farooqi, T.; Pottoo, F.H.; Anwar, S.; Rengasamy, K.R.R. 2021: Targets and strategies for vaccine development against SARS-CoV-2. Biomedicine and PharmacoTherapy 137: 111254
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Daou, B.J.; Koduri, S.; Pandey, A.S. 2021: Targets for Payment Reform in Mechanical Thrombectomy. World Neurosurgery 145: 510-511
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Wang, H.; Xie, Y.; Guan, L.; Elkin, K.; Xiao, J. 2021: Targets identified from exercised heart: killing multiple birds with one stone. Npj Regenerative Medicine 6(1): 23
Coker, M.Austin.; Glaser, Z.A.; Gordetsky, J.B.; Thomas, J.V.; Rais-Bahrami, S. 2018: Targets missed: predictors of MRI-targeted biopsy failing to accurately localize prostate cancer found on systematic biopsy. Prostate Cancer and Prostatic Diseases 21(4): 549-555
Grifoni, A.; Weiskopf, D.; Ramirez, S.I.; Mateus, J.; Dan, J.M.; Moderbacher, C.R.; Rawlings, S.A.; Sutherland, A.; Premkumar, L.; Jadi, R.S.; Marrama, D.; de Silva, A.M.; Frazier, A.; Carlin, A.F.; Greenbaum, J.A.; Peters, B.; Krammer, F.; Smith, D.M.; Crotty, S.; Sette, A. 2020: Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell 181(7): 1489-1501.E15
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Fardouly, J.; Pinkus, R.T.; Vartanian, L.R. 2021: Targets of comparison and body image in women's everyday lives: the role of perceived attainability. Body Image 38: 219-229
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