EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease


The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease



Nature Medicine 17(4): 439-447



ISSN/ISBN: 1078-8956

PMID: 21475241

DOI: 10.1038/nm.2333

The term spreading depolarization describes a wave in the gray matter of the central nervous system characterized by swelling of neurons, distortion of dendritic spines, a large change of the slow electrical potential and silencing of brain electrical activity (spreading depression). In the clinic, unequivocal electrophysiological evidence now exists that spreading depolarizations occur abundantly in individuals with aneurismal subarachnoid hemorrhage, delayed ischemic stroke after subarachnoid hemorrhage, malignant hemispheric stroke, spontaneous intracerebral hemorrhage or traumatic brain injury. Spreading depolarization is induced experimentally by various noxious conditions including chemicals such as potassium, glutamate, inhibitors of the sodium pump, status epilepticus, hypoxia, hypoglycemia and ischemia, but it can can also invade healthy, naive tissue. Resistance vessels respond to it with tone alterations, causing either transient hyperperfusion (physiological hemodynamic response) in healthy tissue or severe hypoperfusion (inverse hemodynamic response, or spreading ischemia) in tissue at risk for progressive damage, which contributes to lesion progression. Therapies that target spreading depolarization or the inverse hemodynamic response may potentially treat these neurological conditions.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 072749587

Download citation: RISBibTeXText

Related references

Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury. Geroscience 42(1): 57-80, 2020

Oxygen free radical production measured online during cortical spreading depression Spreading hyperemia vs spreading ischemia. Society for Neuroscience Abstracts 21(1-3): 224, 1995

Cilostazol decreases duration of spreading depolarization and spreading ischemia after aneurysmal subarachnoid hemorrhage. Annals of Neurology 84(6): 873-885, 2018

Correlates of Spreading Depolarization, Spreading Depression, and Negative Ultraslow Potential in Epidural Versus Subdural Electrocorticography. Frontiers in Neuroscience 13: 373, 2019

Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiological Reviews 81(3): 1065-1096, 2001

Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury?. Glia 64(1): 5-20, 2016

Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia. Stroke 36(6): 1270-1277, 2005

Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia. Stroke (1970) 36(6): 1270-1277, 2005

Cortical spreading ischemia A novel phenomenon induced by cortical spreading depression , NOS inhibition and elevated extracellular potassium. Society for Neuroscience Abstracts 21(1-3): 225, 1995

Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain: a Journal of Neurology 135(Part 1): 259-275, 2012

Exploring the role of microglia in cortical spreading depression in neurological disease. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 37(4): 1182-1191, 2017

Spreading rate, spreading obliquity, and melt supply at the ultraslow spreading Southwest Indian Ridge. Geochemistry, Geophysics, Geosystems - G (super 3) 9(4): (Citation Q04002, 2008

Spreading of spray mixtures on leaf surfaces ii. cohesive interaction parameters as predictors of spreading and the effect of molar volume and roughness on spreading. Pesticide Science 28(4): 431-448, 1990

Plasmatocyte spreading peptide induces spreading of plasmatocytes but represses spreading of granulocytes. Archives of Insect Biochemistry and Physiology 42(3): 213-223, 1999

Selective block of reversal memory by physostigmine injection hippocampal spreading depression or cortical spreading depression. Federation Proceedings: 389, 1971