+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Diagnosis of Dental Fluorosis Using Micro-Raman Spectroscopy Applying a Principal Component-Linear Discriminant Analysis

Diagnosis of Dental Fluorosis Using Micro-Raman Spectroscopy Applying a Principal Component-Linear Discriminant Analysis

International Journal of Environmental Research and Public Health 18(20)

PMID: 34682316

Dental fluorosis is an irreversible condition caused by excessive fluoride consumption during tooth formation and is considered a public health problem in several world regions. The objective of this study was to evaluate the capability of micro-Raman spectroscopy to classify teeth of different fluorosis severities, applying principal component analysis and linear discriminant analysis (PCA-LDA), and estimate the model cross-validation accuracy. Forty teeth of different fluorosis severities and a control group were analyzed. Ten spectra were captured from each tooth and a total of 400 micro-Raman spectra were acquired in the wavenumber range of 250 to 1200 cm-1, including the bands corresponding to stretching and bending internal vibrational modes ν1, ν2, ν3, and ν4 (PO43-). From the analysis of the micro-Raman spectra an increase in B-type carbonate ion substitution into the phosphate site of the hydroxyapatite as fluorosis severity increases was identified. The PCA-LDA model showed a sensitivity and specificity higher than 94% and 93% for the different fluorosis severity groups, respectively. The cross-validation accuracy was higher than 90%. Micro-Raman spectroscopy combined with PCA-LDA provides an adequate tool for the diagnosis of fluorosis severity. This is a non-invasive and non-destructive technique with promising applications in clinical and epidemiological fields.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 079375281

Download citation: RISBibTeXText

Related references

Early detection of dental fluorosis using Raman spectroscopy and principal component analysis. Lasers in Medical Science 30(6): 1675-1681, 2015

Multivariate analysis of micro-Raman spectra of thermoplastic polyurethane blends using principal component analysis and principal component regression. Applied Spectroscopy 66(11): 1269-1278, 2012

Discriminant analysis of Chinese patent medicines based on near-infrared spectroscopy and principal component discriminant transformation. Spectrochimica Acta. Part A Molecular and Biomolecular Spectroscopy 149: 985-990, 2015

Tracing the origin of paracetamol tablets by near-infrared, mid-infrared, and nuclear magnetic resonance spectroscopy using principal component analysis and linear discriminant analysis. Analytical and Bioanalytical Chemistry 413(11): 3107-3118, 2021

Improvements in Alzheimer's Disease Diagnosis using Principal Component Analysis (PCA) in Combination with Raman Spectroscopy. Diagnostic Optical Spectroscopy in Biomedicine: 662810.1-662810.10, 2007

Finger-based personal authentication: a comparison of feature-extraction methods based on principal component analysis, most discriminant features and regularised-direct linear discriminant analysis. Iet Signal Processing 3(4): 269-281, 2009

Kernel principal component analysis and differential non-linear feature extraction of pesticide residues on fruit surface based on surface-enhanced Raman spectroscopy. Frontiers in Plant Science 13: 956778, 2022

Multispectral magnetic resonance image analysis using principal component and linear discriminant analysis. Journal of Magnetic Resonance Imaging: Jmri 17(2): 261-269, 2003

Linear discriminant analysis and principal component analysis to predict coronary artery disease. Health Informatics Journal 26(3): 2181-2192, 2020

Comparative study of DNA microarray data analysis Principal Component Analysis verses Fisher Linear Discriminant Analysis. Toxicological Sciences 72(S-1): 92, 2003

Use of Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) in Gas Chromatographic (GC) Data in the Investigation of Gasoline Adulteration. Energy and Fuels 21(6): 3394-3400, 2007

Analysis of the molecular structure of human enamel with fluorosis using micro-Raman spectroscopy. Journal of Oral Science 54(1): 93-98, 2012

Comparison of principal component analysis and biochemical component analysis in Raman spectroscopy for the discrimination of apoptosis and necrosis in K562 leukemia cells. Optics Express 20(20): 22158-22171, 2012

Short prokaryotic DNA fragment binning using a hierarchical classifier based on linear discriminant analysis and principal component analysis. Journal of Bioinformatics and Computational Biology 8(6): 995-1011, 2010

Short Prokaryotic DNA Fragment Binning using a Hierarchical Classifier Based on Linear Discriminant Analysis and Principal Component Analysis. Journal of Bioinformatics and Computational Biology 8(6): 995-1011, 2010