Section 80
Chapter 79,576

Amphiphilic DTPA Multimer Assembled on Icosahedral Closo-Borane Motif as High-Performance MRi Blood Pool Contrast Agent

Goswami, L.N.; Chakravarty, S.; Cai, Q.-Y.; Shapiro, E.M.; Hawthorne, M.F.; Ma, L.

Acs Applied Bio Materials 4(9): 6658-6663


ISSN/ISBN: 2576-6422
PMID: 35006969
DOI: 10.1021/acsabm.1c00717
Accession: 079575506

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A multimeric MRI blood pool contrast agent based on the closo-borane motif is reported. Twelve copies of an amphiphilic DTPA chelate with amine end groups are appended on carbonate-functionalized closo-borane motif using carbamate linkages. The presence of peripheral phenyl groups on the modified DTPA chelates results in high human serum albumin binding, high relaxivity, and excellent contrast enhancement in vitro and in vivo.

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