Section 80
Chapter 79,828

Pharmacometrics Approaches and its Applications in Diabetes: An Overview

Aziz, S.; Harun, S.N.; Sulaiman, S.A.S.; Ghadzi, S.M.S.

Journal of Pharmacy and Bioallied Sciences 13(4): 335-340


ISSN/ISBN: 0976-4879
PMID: 35399800
Accession: 079827954

Download citation:  

Type 2 diabetes mellitus is the most prevalent and progressive in nature. As the time progress, the multifaceted complications and comorbidities associated to diabetes worsen in the form of macrovascular or microvascular or both. Pharmacometrics modeling is a step forward in minimizing the risk or at least understanding the factors associated to its progression with the passage of time. These models investigate diabetes treatments effects and the progression factors with different viewpoints incorporating insulin-glucose dynamics, dose-response and pharmacokinetics, and pharmacodynamics relationships. Pharmacometrics modeling is an innovative approach in a sense that it is taking us away from the conventional analysis by providing all the opportunities in improving the decision-making in health sector. It has been suggested that we can achieve greater statistical power for determining drug effects through model-based evaluation than through traditional evaluations. The main aim of this review was to evaluate pharmacometrics approaches used in modeling diabetes progression through time and also the integrated models describing glucose-insulin dynamics.

PDF emailed within 1 workday: $29.90