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Comparative Evaluation of Clinical Efficacy of Leukocyte-Rich Platelet-Rich Fibrin with Advanced Platelet-Rich Fibrin in Management of Gingival Recession Defects: a Randomized Controlled Trial

Tadepalli, A.; Chekurthi, S.; Kavassery Balasubramanian, S.; Parthasarathy, H.; Ponnaiyan, D.

Medical Principles and Practice: International Journal of the Kuwait University Health Science Centre 31(4): 376-383

2022


ISSN/ISBN: 1423-0151
PMID: 35728577
Accession: 080043141

The aim of this research was to determine and compare the clinical efficacy of leukocyte platelet rich fibrin (L-PRF) and advanced platelet rich fibrin (A-PRF) in combination with coronally advanced flap (CAF) in the treatment of gingival recession defects. Systemically healthy subjects presenting with 30 Miller's class I or II gingival recession defects in maxillary anteriors and premolars, were either treated with CAF+L-PRF or CAF+A-PRF. Clinical parameters such as recession height (RH), width (RW), probing pocket depth (PPD), clinical attachment level (CAL), keratinized tissue height (KTH) and width of attached gingiva (WAG) were measured at baseline, 3 and 6 months. Gingival biotype was evaluated at baseline and 6 months post-surgery. Mean root coverage percentage (MRC%) was evaluated at 3 and 6 months. Statistically significant reduction in mean RH was observed from baseline (2.53±0.74 mm), (2.63±0.82mm) to 6 months (0.87±0.834mm), (0.53±0.915mm) in CAF+L-PRF and CAF+A-PRF group respectively. The MRC% achieved at 6 months was 67.20±32.81 in CAF+L-PRF group and 81.66±28.21 in CAF+A-PRF group. Statistically significant gain in CAL, WAG and KTH were observed in both therapeutic groups (p<0.05). Intergroup analysis revealed no statistical significant differences among study parameters between groups at any time point (p value>0.05). Based on the findings of this study, both L-PRF and A-PRF may be suggested as viable treatment options for the management of gingival recession in maxilla.

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