Section 81
Chapter 80,283

Click chemistry aided synthesis of 1,4-substituted 1,2,3-triazole based N-Fmoc protected epsilon-amino acids: isolation, characterization and synthesis of novel triazole based unnatural amino acids

Sureshbabu, V.V.; Narendra, N.; Hemantha, H.P.; Chennakrishnareddy, G.

Protein and Peptide Letters 17(4): 499-506


ISSN/ISBN: 1875-5305
PMID: 19961431
Accession: 080282232

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A new class of 1,4-substituted 1,2,3-triazole-based unnatural amino acids is demonstrated by employing click reaction between N-Fmoc amino alkyl azides and propiolic acid. The resulting unnatural amino acids were isolated and then subjected to Fmoc deprotection to isolate 1,2,3-triazole based amino acids as stable solids. These new class of molecules were also used for chain extension from both N- and C-terminals to synthesize dipeptidomimetics bearing 1,2,3-triazole moiety in the backbone.

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