New Thiazole Acetic Acid Derivatives: a Study to Screen Cardiovascular Activity Using Isolated Rat Hearts and Blood Vessels

Raghunatha, P.; Inamdar, M.N.; Asdaq, S.M.B.; Almuqbil, M.; Alzahrani, A.R.; Alaqel, S.I.; Kamal, M.; Alsubaie, F.H.; Alsanie, W.F.; Alamri, A.S.; Rabbani, S.I.; Attimarad, M.; Mohan, S.; Alhomrani, M.

Molecules 27(19)

2022


ISSN/ISBN: 1420-3049
PMID: 36234675
Accession: 080576483

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Abstract
Cardiovascular diseases are one of the major causes of mortalities worldwide. In the present research, new synthetic derivatives of thiazole were studied using isolated hearts and blood vessels of rats. The heart and thoracic aorta were tested with six new synthesized thiazole acetic acid derivatives (SMVA-10, SMVA-35, SMVA-40, SMVA-41, SMVA-42 and SMVA-60), and the data obtained were statistically analyzed and compared. Isolated rat hearts were used to record the changes in developed tension and heart rate, while thoracic aortas were used to measure the contractile response, before and after treatments. Analysis of the results indicated a significant (p < 0.01) increase in developed tension with the addition of SMVA-35, SMVA-40, SMVA-41 and SMVA-42, which was augmented in the presence of adrenaline without affecting the heart rate. On the other hand, acetylcholine significantly decreased the developed tension, which was significantly reversed (p < 0.01) in the presence of compounds (SMVA-35 and SMVA-60). However, in the presence of SMVA-35 and SMVA-40, acetylcholine-induced bradycardia was significantly (p < 0.01) reduced. Furthermore, only SMVA-42 induced a dose-dependent contractile response in the isolated blood vessel, which was abolished in the presence of prazosin. Therefore, it can be concluded that some of the new synthesized thiazole derivatives exhibited promising results by raising the developed tension without changing the heart rate or blood vessel function, which could be helpful in failing heart conditions. However, more research is required to fully comprehend the function, mechanism and effectiveness of the compounds.