A quantitative LC-MS/MS method for simultaneous determination of deuvortioxetine, vortioxetine and their carboxylic acid metabolite in rat plasma, and its application to a toxicokinetic study

Qin, M.; Qiao, H.; Yuan, Y.; Shao, Q.

Analytical Methods 10(9): 1023-1031

2018


ISSN/ISBN: 1759-9660
Accession: 081361039

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Abstract
A rapid, simple, efficient and stable method based on LC-MS/MS for simultaneous determination of deuvortioxetine, vortioxetine and their carboxylic acid metabolite in rat plasma has been established and validated.