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The use and limitations of current 'standard' toxicological data packages in the setting of acute reference doses

Dewhurst, I.C.

Food Additives and Contaminants 17(7): 611-615

2000

ISSN/ISBN: 0265-203X
PMID: 10983585
DOI: 10.1080/026520300412528
Accession: 003596545

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Summary
To perform risk assessments for short term dietary intakes of pesticides it is necessary to determine an acceptable level of exposure from the available toxicity studies. This type of assessment is a relatively new development in regulatory toxicology and often the studies currently available are not optimal for such uses. The strengths and weaknesses of currently performed study types are presented. Consideration of the entire toxicity data base is essential.

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