Peroxidation of human plasma lipoproteins induced by hypochlorite anion

Evgina, S.A.; Panasenko, O.M.; Sergienko, V.I.; Vladimirov, Y.A.; Evgina, S.A; Panasenko, O.M; Sergienko, V.I; Vladimirov, Y.A

Home

>

Section

>

Chapter

Peroxidation of human plasma lipoproteins induced by hypochlorite anion

Evgina, S.A.; Panasenko, O.M.; Sergienko, V.I.; Vladimirov, Y.A.

Biologicheskie Membrany 9(9): 946-953

1992

ISSN/ISBN: 0233-4755

Accession: 009175301

Full-Text Article emailed within 1 workday

Payments are secure & encrypted

Summary

Oxidation of human plasma lipoproteins (LP) was studied in the presence of exogenous OCl- (hypochlorite-anion) or OCl- generated in the system of "myeloperoxidase + H-2O-2 + Cl-". OCl- was shown to catalyze peroxidation of lipids being part of LP. It was judged by accumulation of secondary (thiobarbituric acid reactive substances) products of lipid peroxidation (LPO) in LP after incubation with myeloperoxidase or exogenous OCl-. Very low density and low density lipoproteins which are known to be classified as atherogenic appeared to be more sensitive to OCl--induced LPO than highly density lipoproteins. The results allowed us to make the hypothesis suggesting that OCl- secreted by activated neutrophils and monocyte-macrophages can be in vivo the reason of oxidative modification of LP that is the important risk factor in the development of atherosclerosis.