Effects of anti-histaminics on histamine intracutaneous reaction

Uchi, C.; Uchi, C

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Effects of anti-histaminics on histamine intracutaneous reaction

Uchi, C.

Shikoku Acta Med 16(5): 78-88

1960

Accession: 024573972

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Summary

In consideration of the pharmacodynamic action of histamine, histamine contributes significantly to the preservation of health. Making erythematous-reaction as provoked by the intracutaneous injection of 0.1 cc 10.000 fold diluent of histamine hydrochloride. Respectively 10 healthy males and females (11-14 yrs. old) were subjected to this experiment and the results were analyzed. (1) Intracutaneous injection of histamine solution mixed with 5 kinds of antihistaminics made reaction roughly 50% weaker and retarded the time necessary to reach at the reactional zenith. (2) Controlling effect of histamine reaction provoked by the subcutaneous injection of anti-histaminics 20-30 minutes after procedure, this effect continued 50 minutes after procedure (roughly 20%). (3) Individually, 5 different anti-histaminics and histamine injected subcutaneously, showed very little difference; while anti-histamine-histamine injected in combination, showed marked individual differences.