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Cytochromes P450, P420 and mixed-function oxidases as biomarkers of polychlorinated biphenyl (PCB) exposure in harbour seals (Phoca vitulina)

Troisi, G.M.; Mason, C.F.

Chemosphere 35(9): 1933-1946

1997

ISSN/ISBN: 0045-6535
PMID: 9353910
DOI: 10.1016/s0045-6535(97)00268-3
Accession: 045693701

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Summary
Hepatic microsomal cytochrome P450, EROD and ECOD activity were investigated as biomarkers of PCB exposure in harbour seals (Phoca vitulina). Due to the difficulty of obtaining undegraded seal liver samples, standard spectrophotometric methodology was adapted to investigate P420 (degraded P450) as a PCB biomarker with partially degraded samples. Total PCB burdens in both blubber and liver had positive correlations with P450, P420 and MFO activity levels. The use of P420 biomarkers in this study supports the inclusion of samples from by-caught marine mammals for future biomonitoring studies. P450 isozymes CYP1A (P4501A) and CYP2B (P4502B) in conjunction with MFO activity were investigated as "specific" biomarkers of PCB exposure. They were found to reliably reflect levels of [MC] and [PB]-type PCB exposure in harbour seal liver.

References

Boon, J.P.; Reijnders, P.J.H.; Dols, J.; Wensvoort, P.; Hillebrand, M.T.J. 1987: The kinetics of individual polychlorinated biphenyl congeners in female harbour seals phoca vitulina with evidence for structure related metabolism Aquatic Toxicology (Amsterdam) 10(5-6): 307-324
Noël, M.; Dangerfield, N.; Jeffries, S.; Lambourn, D.; Lance, M.; Helbing, C.; Lebeuf, M.; Ross, P.S. 2017: Polychlorinated Biphenyl-Related Alterations of the Expression of Essential Genes in Harbour Seals (Phoca vitulina) from Coastal Sites in Canada and the United States Archives of Environmental Contamination and Toxicology 73(2): 310-321
Hammill, M.O.; Stenson, G.B. 2000: Estimated prey consumption by harp seals (Phoca groenlandica), hooded seals (Cystophora cristata), grey seals (Halichoerus grypus) and harbour seals (Phoca vitulina) in Atlantic Canada Journal of Northwest Atlantic Fishery Science 26: 1-23
Storr-Hansen, E.; Spliid, H.; Boon, J.P. 1994: Chlorinated biphenyl congeners in harbour seals (Phoca vitulina) and in their food. Statistical comparison of the patterns Organohalogen Compounds 20: 225-228
Henriksen, G. 2000: Harbour seals Phoca vitulina along the Skagerrak coast, southern Norway Steinkobbe Phoca vitulina langs Skagerrakkysten Fauna (Oslo): 534: 199-217
Bernhoft, A.; Skaare, J.U. 1994: Levels of selected individual polychlorinated biphenyls in different tissues of harbour seals (Phoca vitulina) from the southern coast of Norway Environmental Pollution (1987) 86(1): 99-107
Bernhoft, A.; Skaare, J.U. 1994: Levels of selected individual polychlorinated biphenyls in different tissues of harbour seals (phoca vitulina) from the Southern coast of Norway Environmental Pollution 86(1): 99-107
Harder, T.C.; Willhaus, T.; Leibold, W.; Liess, B. 1992: Investigations on course and outcome of phocine distemper virus infection in harbour seals phoca vitulina exposed to polychlorinated biphenyls Journal of Veterinary Medicine Series B 39(1): 19-31
Storr-Hansen, E.; Spliid, H. 1993: Coplanar polychlorinated biphenyl congener levels and patterns and the identification of separate populations of harbor seals (Phoca vitulina) in Denmark Archives of Environmental Contamination and Toxicology 24(1): 44-58
Kershaw, J.L.; Stubberfield, E.J.; Foster, G.; Brownlow, A.; Hall, A.J.; Perrett, L.L. 2017: Exposure of harbour seals Phoca vitulina to Brucella in declining populations across Scotland Diseases of Aquatic Organisms 126(1): 13-23
Sonne, C.; Vorkamp, K.; Galatius, A.; Kyhn, L.; Teilmann, J.; Bossi, R.; Søndergaard, J.; Eulaers, I.; Desforges, J.-P.; Siebert, U.; Dietz, R. 2019: Human exposure to Pfos and mercury through meat from baltic harbour seals (Phoca vitulina) Environmental Research 175: 376-383
Sonne, C.; Vorkamp, K.; Galatius, A.; Kyhn, L.; Teilmann, J.; Bossi, R.; Søndergaard, J.; Eulaers, I.; Desforges, J.-P.; Siebert, U.; Dietz, R. 2019: Human exposure to PFOS and mercury through meat from baltic harbour seals (Phoca vitulina) Environmental Research 175: 376-383
Addison, R.F.; Ikonomou, M.G.; Smith, T.G. 2005: PCDD/F and PCB in harbour seals (Phoca vitulina) from British Columbia: response to exposure to pulp mill effluents Marine Environmental Research 59(2): 165-176
Ross, P.S.; Jeffries, S.J.; Yunker, M.B.; Addison, R.F.; Ikonomou, M.G.; Calambokidis, J.C. 2004: Harbor seals (Phoca vitulina) in British Columbia, Canada, and Washington State, USA, reveal a combination of local and global polychlorinated biphenyl, dioxin, and furan signals Environmental Toxicology and Chemistry 23(1): 157-165
Cronin, M.; Zuur, A.; Rogan, E.; McConnell, B. 2009: Using mobile phone telemetry to investigate the haul-out behaviour of harbour seals Phoca vitulina vitulina Endangered Species Research 10: 255-267
Reder, S.; Lydersen, C.; Arnold, W.; Kovacs, K.M. 2003: Haulout behaviour of High Arctic harbour seals (Phoca vitulina vitulina) in Svalbard, Norway Polar Biology 27(1): 6-16
Wilson, S.C.; Armstrong, M.J.; Pierce, G.J.; Corpe, H.M. 1996: The diet of harbour seals (Phoca vitulina vitulina) from Dundrum Bay, Co. Down Environment and Heritage Service Research and Development Series, 9713: i, 7.1-7.14
Reed, J.Z.; Butler, P.J.; Fedak, M.A. 1994: The metabolic characteristics of the locomotory muscles of grey seals (Halichoerus grypus), harbour seals (Phoca vitulina) and Antarctic fur seals (Arctocephalus gazella) Journal of Experimental Biology 194: 33-46
Wilson, S.C. 1996: The scanning levels of moulting groups of harbour seals (Phoca vitulina vitulina) in Co. Down, in disturbed and undisturbed contexts Environment and Heritage Service Research and Development Series, 9713: i, 5.1-5.9
Harder, T.C.; Willhaus, T.; Leibold, W.; Liess, B. 1992: Investigations on course and outcome of phocine distemper virus infection in harbour seals (Phoca vitulina) exposed to polychlorinated biphenyls. Virological and serological investigations Zentralblatt für Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B 39(1): 19-31