Thyroid Dysfunction of Zebrafish (Danio rerio) after Early-Life Exposure and Discontinued Exposure to Tetrabromobiphenyl (BB-80) and OH-BB-80

Zhang, X.; Sun, Y.; Gao, Y.; Liu, Z.; Ding, J.; Zhang, C.; Liu, W.; Zhang, H.; Zhuang, S.; Zhang, X; Sun, Y; Gao, Y; Liu, Z; Ding, J; Zhang, C; Liu, W; Zhang, H; Zhuang, S

doi:10.1021/acs.est.1c07767

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Thyroid Dysfunction of Zebrafish (Danio rerio) after Early-Life Exposure and Discontinued Exposure to Tetrabromobiphenyl (BB-80) and OH-BB-80

Zhang, X.; Sun, Y.; Gao, Y.; Liu, Z.; Ding, J.; Zhang, C.; Liu, W.; Zhang, H.; Zhuang, S.

Environmental Science and Technology 56(4): 2519-2528

2022

ISSN/ISBN: 1520-5851

PMID: 35075897

DOI: 10.1021/acs.est.1c07767
Accession: 079620985

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Summary

3,3',5,5'-Tetrabromobiphenyl (BB-80) was once used as additive flame retardants. Whether its early exposure and discontinued exposure alter thyroid function remains unknown. We investigate adverse effects after early-life exposure and discontinued exposure to BB-80 and hydroxylated BB-80 (OH-BB-80) on thyroid hormone (TH) levels, thyroid tissue, and transcriptome profiles in zebrafish larvae. BB-80 at 10 μg/L induces pathological changes of thyroid with reduced thyroid follicles in larvae (P < 0.05), whereas OH-BB-80 significantly increases T4 and T3 contents (1.8 and 2.5 times of the control, P < 0.05) at 14 days postfertilization (dpf) without morphological thyroid alterations. BB-80 and OH-BB-80 cause transcriptome aberrations with key differentially expressed genes involved in the disruption of TH synthesis and signal transduction (BB-80 at 14 dpf) or TH pathway activation (OH-BB-80 at 21 dpf). After 7 days of discontinued exposure, thyroglobulin (tg) and thyroid peroxidase (tpo) genes are downregulated (P < 0.05) by 52 and 48% for BB-80 and by 49 and 39% for OH-BB-80, respectively; however, the whole-body TH levels fail to fully recover, and the locomotor activity is impaired more by BB-80. Our results indicate significant adverse impacts of BB-80 and OH-BB-80 on TH homeostasis and thyroid function of zebrafish.

Thyroid Dysfunction of Zebrafish (Danio rerio) after Early-Life Exposure and Discontinued Exposure to Tetrabromobiphenyl (BB-80) and OH-BB-80

Zhang, X.; Sun, Y.; Gao, Y.; Liu, Z.; Ding, J.; Zhang, C.; Liu, W.; Zhang, H.; Zhuang, S.

Environmental Science and Technology 56(4): 2519-2528

2022

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