Novel Chitosan Dermal Filler with Enhanced Moldability and Elasticity

Kim, J.Y.; Kim, S.H.; Choi, M.-H.; Lee, S.H.; Cha, M.; Park, J.-U.; Kim, J.Y; Kim, S.H; Choi, M.-H; Lee, S.H; Cha, M; Park, J.-U

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Novel Chitosan Dermal Filler with Enhanced Moldability and Elasticity

Kim, J.Y.; Kim, S.H.; Choi, M.-H.; Lee, S.H.; Cha, M.; Park, J.-U.

Macromolecular Bioscience 22(8): E2200081

2022

ISSN/ISBN: 1616-5195

PMID: 35698278

Accession: 080024587

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Summary

Currently, dermal fillers are largely based on commercialized cross-linked hyaluronic acid (HA) injections, which require a large injection force. Additionally, HA can be easily decomposed by enzymes, and HA-treated tissues present a risk of developing granuloma. In this study, a chitosan-based dermal filler is presented that operates on a liquid-to-gel transition and allows the injection force to be kept ≈4.7 times lower than that required for HA injections. Evaluation of the physical properties of the chitosan filler indicates high viscoelasticity and recovery rate after gelation at 37 °C. Furthermore, in an in vivo evaluation, the liquid injection-type chitosan filler transitions to a gel state within 5 min after injection into the body, and exhibits a compressive strength that is ≈2.4 times higher than that of cross-linked HA. The filler also exhibits higher moldability and maintains a constant volume in the skin for a longer time than the commercial HA filler. Therefore, it is expected that the chitosan filler will be clinically applicable as a novel material for dermal tissue restoration and supplementation.