Top Buy Now Summary References
Home
>
Section
>
Chapter

Duration and timing of bisphosphonate treatment as factors determining osteoblast mineralization

Patntirapong, S.

Journal of Oral Biology and Craniofacial Research 12(5): 575-579

2022

ISSN/ISBN: 2212-4268
PMID: 35957942
DOI: 10.1016/j.jobcr.2022.07.011
Accession: 080186880

Full-Text Article emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Summary
Alendronate is a drug for the treatment of excessive bone resorption. Alendronate reduces osteoblast viability and mineralization in a dose-dependent manner. Other views of alendronate could affect mineralization. Therefore, the effects of timing and duration of alendronate treatment on mineralization were investigated. MC3T3 cells were treated with alendronate at different time periods ranging from 1 to 3 weeks. Mineralization was quantified using image analysis. Cell viability was measured by Thiazolyl Blue Tetrazolium Bromide assay. At low concentration (1 μM), 2-3 weeks of alendronate addition decreased mineralized area and staining intensity. Longer exposure to alendronate had more effect than short exposure. At moderate to high concentrations (5-10 μM), every alendronate treatment timing inhibited mineralization. Week 3 treatment of alendronate showed less reduction of mineralization than other time treatments. Furthermore, 10 μM alendronate reduced osteoblast viability at week 1, week 1-2, and week 1-3. Timing and duration of alendronate addition inhibited total mineralization. Longer period of treatment reduced mineralization more than short period of treatment. In addition, reduction of total mineralization depended upon both osteoblast viability and function.

References

Beuvelot, J.; Portet, D.; Lecollinet, G.ég.; Moreau, M.-F.ço.; Baslé, M.F.él.; Chappard, D.; Libouban, H.él.èn. 2009: In vitro kinetic study of growth and mineralization of osteoblast-like cells (Saos-2) on titanium surface coated with a RGD functionalized bisphosphonate Journal of Biomedical Materials Research. Part B Applied Biomaterials 90(2): 873-881
Portillo, M.T.; Marwah, A.; Kraemer, M.U.G.; Thomas-Bachli, A.; Khan, K.; Bogoch, I.I. 2024: Potential for international spread of Oropouche virus via commercial air travel Journal of Travel Medicine 31(8): taae128
Manzano-Moreno, F.J.; Ramos-Torrecillas, J.; Melguizo-Rodríguez, L.; Illescas-Montes, R.; Ruiz, C.ón.; García-Martínez, O. 2018: Bisphosphonate Modulation of the Gene Expression of Different Markers Involved in Osteoblast Physiology: Possible Implications in Bisphosphonate-Related Osteonecrosis of the Jaw International Journal of Medical Sciences 15(4): 359-367
Farlay, D.; Rizzo, S.éb.; Ste-Marie, L.-G.; Michou, L.ët.; Morin, S.N.; Qiu, S.; Chavassieux, P.; Chapurlat, R.D.; Rao, S.D.; Brown, J.P.; Boivin, G. 2021: Duration-Dependent Increase of Human Bone Matrix Mineralization in Long-Term Bisphosphonate Users with Atypical Femur Fracture Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research 36(6): 1031-1041
Schoephoerster, J.; Roston, S.; Lunos, S.; Ramel, S.E.; Anderson, J.; Georgieff, M.K.; Ingolfsland, E.C. 2023: Identification of clinical factors associated with timing and duration of spontaneous regression of retinopathy of prematurity not requiring treatment Journal of Perinatology: Official Journal of the California Perinatal Association 43(6): 702-708
Lewchuk, M.T.; Symons, D.T.A. 1995: Paleomagnetic analysis of several MVT ore districts using Bingham statistics; further evidence for the timing and duration of mineralization International Union of Geodesy and Geophysics, General Assembly 21, Week B: 120
Seth, A. 2000: Ets transcription factors and targets in osteoblast differentiation and matrix mineralization Journal of Bone and Mineral Research 15(Suppl 1): S342
Ryota Sekine; Eiji Izawa; Koichiro Watanabe 2002: Timing of Fracture Formation and Duration of Mineralization at the Hishikari Deposit, Southern Kyushu, Japan Resource Geology 52(4): 395-404
Vary, C.P.; Li, V.; Raouf, A.; Kitching, R.; Kola, I.; Franceschi, C.; Venanzoni, M.; Seth, A. 2000: Involvement of Ets transcription factors and targets in osteoblast differentiation and matrix mineralization Experimental Cell Research 257(1): 213-222
Rizzoli, R.é 2004: Duration of treatment against osteoporosis using bisphosphonate Revue Medicale de la Suisse Romande 124(2): 105-107
Al-Jallad, H.F.; Nakano, Y.; Chen, J.L.Y.; McMillan, E.; Lefebvre, C.él.; Kaartinen, M.T. 2006: Transglutaminase activity regulates osteoblast differentiation and matrix mineralization in MC3T3-E1 osteoblast cultures Matrix Biology: Journal of the International Society for Matrix Biology 25(3): 135-148
Yang, H.M.; Shin, H.-K.; Kang, Y.-H.; Kim, J.-K. 2009: Cuscuta chinensis extract promotes osteoblast differentiation and mineralization in human osteoblast-like MG-63 cells Journal of Medicinal Food 12(1): 85-92
Harada, S.; Matsumoto, T.; Ogata, E. 1990: Prostate derived growth factors with stimulatory effects on proliferation and mineralization in osteoblast like cells Calcified Tissue International 46(Suppl 2): A41
Burdick, J.A.; Mason, M.N.; Hinman, A.D.; Thorne, K.; Anseth, K.S. 2002: Delivery of osteoinductive growth factors from degradable PEG hydrogels influences osteoblast differentiation and mineralization Journal of Controlled Release: Official Journal of the Controlled Release Society 83(1): 53-63
Daci, E.; Torrekens, S.; Bouillon, R.; Carmeliet, G. 2000: Deficiency of the plasminogen activators enhances osteoblast proliferation, in vitro mineralization and expression of osteoblast specific markers Journal of Bone and Mineral Research 15(Suppl 1): S349
Reinholz, G.G.; Getz, B.; Spelsberg, T.C. 2001: Inhibition of human osteoblast proliferation and mineralization by breast cancer cell-derived paracrine factors Breast Cancer Research and Treatment 69(3): 314
Vuorimies, I.; Arponen, H.; Valta, H.; Tiesalo, O.; Ekholm, M.; Ranta, H.; Evälahti, M.; Mäkitie, O.; Waltimo-Sirén, J. 2017: Timing of dental development in osteogenesis imperfecta patients with and without bisphosphonate treatment Bone 94: 29-33