Top Buy Now Summary References
Home
>
Section
>
Chapter

Transforming growth factor-beta 1: a new factor reducing hepatic SHBG production in liver fibrosis

Briansó-Llort, L.; Fuertes-Rioja, L.; Ramos-Perez, L.; Salcedo-Allende, M.T.; Hernandez, C.; Simó, R.; Selva, D.M.

Journal of Cellular Physiology 237(9): 3598-3613

2022

ISSN/ISBN: 1097-4652
PMID: 35762039
Accession: 080453840

Full-Text Article emailed within 1 workday
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Summary
Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represents a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different nonalcoholic fatty liver disease mouse models. In the present work, we are interested in elucidating the molecular mechanisms reducing SHBG plasma levels in liver fibrosis. For this purpose, in vivo studies were performed using the human SHBG transgenic mice developing liver fibrosis induced by carbon tetrachloride (CCl4 ). Our results clearly showed that CCl4 induced liver fibrosis and reduced SHBG production by reducing hepatocyte nuclear factor 4 alpha (HNF-4α). The SHBG reduction could be influenced by the increase in transforming growth factor-beta 1 (TGF-β1), which was increased in mice developing liver fibrosis. Therefore, we decided to evaluate the role of TGF-β1 in regulating hepatic SHBG production. Results obtained in both HepG2 cells and human SHBG transgenic mice showed that TGF-β1 reduced significantly SHBG messenger RNA and protein levels. Mechanistically TGF-β1 downregulated P1-HNF-4α isoforms and increased P2-HNF-4α isoforms via Smad3 and Stat3 pathways through TGF-β1 receptor I, resulting in transcriptional repression of the SHBG gene. Taken together, we found for the first time that TGF-β1 is a new factor regulating hepatic SHBG production in liver fibrosis. Further research is needed to determine the role of this reduction in hepatic SHBG production in the progression of nonalcoholic steatohepatitis.

References

Rieder, H.; Armbrust, T.; Meyer zum Büschenfelde, K.H.; Ramadori, G. 1993: Contribution of sinusoidal endothelial liver cells to liver fibrosis: expression of transforming growth factor-beta 1 receptors and modulation of plasmin-generating enzymes by transforming growth factor-beta 1 Hepatology 18(4): 937-944
Khalil, N.; O'Connor, R.; Gold, L.I.; Parekh, T.; Raghu, G. 2001: Biological effects of transforming growth factor-beta(1) in idiopathic pulmonary fibrosis may be regulated by the activation of latent transforming growth factor-beta(1) and the differential expression of transforming growth factor-beta receptors Chest 120(1 Suppl): 48s
Li, L.; Wu, T.; Huang, J.; Ma, K.; Xu, L.; Wang, H.; Fan, X.; Tao, R.; Ai, G.; Ning, Q. 2015: Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis Parasitology 142(2): 341-351
Vanhee, D.; Gosset, P.; Wallaert, B.; Voisin, C.; Tonnel, A.B. 1994: Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity American Journal of Respiratory and Critical Care Medicine 150(4): 1049-1055
Lewindon, P.J.; Pereira, T.N.; Hoskins, A.C.; Bridle, K.R.; Williamson, R.M.; Shepherd, R.W.; Ramm, G.A. 2002: The role of hepatic stellate cells and transforming growth factor-beta(1) in cystic fibrosis liver disease American Journal of Pathology 160(5): 1705-1715
Davidson, J.M.; Zoia, O.; Liu, J.M.n 1993: Modulation of transforming growth factor-beta 1 stimulated elastin and collagen production and proliferation in porcine vascular smooth muscle cells and skin fibroblasts by basic fibroblast growth factor, transforming growth factor-a, and insulin-like growth factor-I Journal of Cellular Physiology 155: 9-56
Chung, Y.H.; Song, B.C.; Kim, J.A.; Jung, S.A.; Park, N.H.; Ryu, S.H.; Shin, J.W.; Jang, M.K.; Lee, H.C.; Lee, Y.S.; Suh, D.J. 2002: Differential expression of transforming growth factor-beta receptors in the liver of rats with acinar zonal hepatic fibrosis Hepatology 36(4 Part 2): 480A
Davidson, J.M.; Zoia, O.; Liu, J.M. 1993: Modulation of transforming growth factor-beta 1 stimulated elastin and collagen production and proliferation in porcine vascular smooth muscle cells and skin fibroblasts by basic fibroblast growth factor, transforming growth factor-alpha, and insulin-like growth factor-i Journal of Cellular Physiology 155(1): 149-156
Seo, H.-Y.; Jung, Y.-A.; Lee, S.-H.; Hwang, J.S.; Park, K.-G.; Kim, M.-K.; Jang, B.K. 2017: Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway Oncotarget 8(50): 87086-87094
Eghbali-Fatourechi, G.; Sieck, G.C.; Prakash, Y.S.; Maercklein, P.; Gores, G.J.; Fitzpatrick, L.A. 1996: Type i procollagen production and cell proliferation is mediated by transforming growth factor-beta in a model of hepatic fibrosis Endocrinology 137(5): 1894-1903
Andresen, J.L.; Ehlers, N. 1998: Chemotaxis of human keratocytes is increased by platelet-derived growth factor-BB, epidermal growth factor, transforming growth factor-alpha, acidic fibroblast growth factor, insulin-like growth factor-I, and transforming growth factor-beta Current Eye Research 17(1): 79-87
Li, Y.-Y.; Wan, F.; Zhang, M. 2017: Effect of total glucosides of paeony on nuclear factor-κB and transforming growth factor β1 in liver tissue of rats with immune hepatic fibrosis Biomedical Research (India) 28(19): 8201-8204
Tu, X.; Zheng, X.; Li, H.; Cao, Z.; Chang, H.; Luan, S.; Zhu, J.; Chen, J.; Zang, Y.; Zhang, J. 2015: MicroRNA-30 Protects Against Carbon Tetrachloride-induced Liver Fibrosis by Attenuating Transforming Growth Factor Beta Signaling in Hepatic Stellate Cells Toxicological sciences: an official journal of the Society of Toxicology 146(1): 157-169
Kim, J.; Kang, W.; Kang, S.Hee.; Park, S.Hyun.; Kim, J.Young.; Yang, S.; Ha, S.Yun.; Paik, Y-Han. 2020: Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis Scientific Reports 10(1): 21018
Masuhara, M.; Katyal, S.L.; Nakamura, T.; Shinozuka, H. 1992: Differential expression of hepatocyte growth factor, transforming growth factor-alpha and transforming growth factor-beta 1 messenger RNAs in two experimental models of liver cell proliferation Hepatology 16(5): 1241-1249
Baugé, C.; Cauvard, O.; Leclercq, S.; Galéra, P.; Boumédiene, K. 2011: Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta Arthritis Research and Therapy 13(1): R23
Davidson, J.M.; Zoia, O. 1990: Basic fibroblast growth factor and transforming growth factor alpha antagonize the stimulation of elastin production by transforming growth factor beta 1 in fibroblasts and smooth muscle cells Matrix 10(4): 254-255
Bachem, M.G.; Riess, U.; Gressner, A.M. 1989: Liver fat storing cell proliferation is stimulated by epidermal growth factor/transforming growth factor alpha and inhibited by transforming growth factor beta Biochemical and Biophysical Research Communications 162(2): 708-714
Rieder, H.; Armbrust, T.; Meyer Zum Buschenfelde, K.H.; Ramadori, G. 1993: Contribution of sinusoidal endothelial liver cells to liver fibrosis : expression of transforming growth factor-β1 receptors and modulation of plasmin-generating enzymes by transforming growth factor-β1 Hepatology (Baltimore, Md.) 18(4): 937-944
Kinnman, N.; Andersson, U.; Hultcrantz, R. 2000: In situ expression of transforming growth factor-beta1-3, latent transforming growth factor-beta binding protein and tumor necrosis factor-alpha in liver tissue from patients with chronic hepatitis C Scandinavian Journal of Gastroenterology 35(12): 1294-1300