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Small Airway Dysfunction in Chronic Bronchitis with Preserved Pulmonary Function

Ding, Q.; Mi, B.-B.; Wei, X.; Li, J.; Mi, J.-Y.; Ren, J.-T.; Li, R.-L.

Canadian Respiratory Journal 2022: 4201786

2022

ISSN/ISBN: 1916-7245
PMID: 36060828
Accession: 080474754

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Summary
Impairment of pulmonary function was evaluated in chronic bronchitis patients with preserved ratio impaired spirometry (PRISm). We retrospectively collected clinical data from 157 chronic bronchitis (CB) and 186 chronic obstructive pulmonary disease (COPD) patients between October 2014 and September 2017. These patients were assigned to three groups: control (normal pulmonary function), PRISm (forced expiratory volume in 1 second [FEV1]/forced vital capacity [FVC] ≥ 0.7, FEV1 < 80% of predicted value), and COPD (FEV1/FVC <0.7) groups. Because small airway function was the main focus, in the COPD group, only patients in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1 and 2 were included. Evaluation of pulmonary function (including impulse oscillometry) was performed and compared among these groups. Compared with the control group, the PRISm and COPD groups showed statistically significant differences in the predicted FEV1% (p < 0.001), maximal expiratory flow (MEF) 25% (p < 0.001), MEF50% (p < 0.001), maximal midexpiratory flow (MMEF) 25-75% (p < 0.001), residual volume (RV)/total lung capacity (TLC; p < 0.001), FVC% (p < 0.001), total respiratory resistance and proximal respiratory resistance (R5-R20; p < 0.001), respiratory system reactance at 5 Hz (X5; p < 0.001), resonant frequency (Fres; p < 0.001), and area of reactance (Ax; p < 0.001). However, the predicted FEV1% and RV/TLC were similar between the PRISm and COPD groups (p=0.992 and 0.122, respectively). PRISm is a nonspecific pattern of pulmonary function that indicates small airway dysfunction and may increase the risk of transformation to obstructive ventilation dysfunction. This trial is registered with ChiCTR-OCH-14004904.

References

Li, L.-Y.; Yan, T.-S.; Yang, J.; Li, Y.-Q.; Fu, L.-X.; Lan, L.; Liang, B.-M.; Wang, M.-Y.; Luo, F.-M. 2021: Impulse oscillometry for detection of small airway dysfunction in subjects with chronic respiratory symptoms and preserved pulmonary function Respiratory Research 22(1): 68
Chiu, H-Yen.; Hsiao, Y-Han.; Su, K-Cheng.; Lee, Y-Chin.; Ko, H-Kuo.; Perng, D-Warng. 2020: Small Airway Dysfunction by Impulse Oscillometry in Symptomatic Patients with Preserved Pulmonary Function Journal of Allergy and Clinical Immunology. in Practice 8(1): 229-235.E3
Stangl, B.; Bizjak, M.; Fortic, M.; Vranjesević, G. 1974: Changes of the pulmonary function in chronic bronchitis with minimal airway obstruction Plucne Bolesti i Tuberkuloza 26 Suppl. 2: 486-490
Fuleihan, F.J.; Feisal, K.A.; Malouf, N.N. 1967: Effect of corticosteroids on pulmonary function in chronic bronchitis with airway obstruction American Review of Respiratory Disease 96(4): 678-684
Thompson, A.B.; Mueller, M.B.; Heires, A.J.; Bohling, T.L.; Daughton, D.; Yancey, S.W.; Sykes, R.S.; Rennard, S.I. 1992: Aerosolized beclomethasone in chronic bronchitis. Improved pulmonary function and diminished airway inflammation American Review of Respiratory Disease 146(2): 389-395
Aikawa, T.; Sasaki, H.; Okayama, H.; Sekizawa, K. 1985: Relation between central and peripheral airway diseases and pulmonary function tests in patients with chronic bronchitis American Review of Respiratory Disease 131(4 Suppl): A70
Bresser, P.; Out, T.A.; van Alphen, L.; Jansen, H.M.; Lutter, R. 2000: Airway inflammation in nonobstructive and obstructive chronic bronchitis with chronic haemophilus influenzae airway infection. Comparison with noninfected patients with chronic obstructive pulmonary disease American Journal of Respiratory and Critical Care Medicine 162(3 Part 1): 947-952
Rath, A.K.; Sahu, D.; De, S. 2024: Oscillometry-Defined Small Airway Dysfunction in Patients with Chronic Obstructive Pulmonary Disease Tuberculosis and Respiratory Diseases 87(2): 165-175
An, Q.Y.; Jiang, R.; Wang, L.; Zhao, Q.H.; Gong, S.G.; He, J.; Luo, C.J.; Liu, M.Q.; Qiu, H.L.; Guo, J.; Liu, J.M. 2018: Peripheral small airway dysfunction differences between idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension Zhonghua Jie he He Hu Xi Za Zhi 41(12): 934-941
Pisi, R.; Aiello, M.; Zanini, A.; Tzani, P.; Paleari, D.; Marangio, E.; Spanevello, A.; Nicolini, G.; Chetta, A. 2015: Small airway dysfunction and flow and volume bronchodilator responsiveness in patients with chronic obstructive pulmonary disease International Journal of Chronic Obstructive Pulmonary Disease 10: 1191-1197
Wang, Z.; Yang, J.; Gao, J.; Wen, F.; Zheng, J.; Ma, Q.; Chen, R.; Sun, Y.; Li, X.; Cao, S.; Gu, C.; Hu, S.; Song, J.; Compton, C.; Jones, P.; Zhong, N. 2023: The Airway Microbiome in Chronic Bronchitis Is Intermediate Between Health and Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine
Lu, D.; Yu, Q.; Chen, L.; Liao, Q.; Lan, J.; Chen, S.; Wang, C.; Zeng, W.; Wu, L.; Fan, C.; Lu, P.; Yu, H. 2021: HRCT quantitative analysis of airway remodeling and airway trapping in the small airway asthma phenotype and its correlation with pulmonary function Journal of Asthma: 1-19
Lu, D.; Yu, Q.; Chen, L.; Liao, Q.; Lan, J.; Chen, S.-B.; Wang, C.; Zeng, W.; Wu, L.; Fan, C.; Lu, P.; Yu, H. 2023: HRCT quantitative analysis of airway remodeling and airway trapping in the small airway asthma phenotype and its correlation with pulmonary function Journal of Asthma: Official Journal of the Association for the Care of Asthma 60(1): 32-42
He, Y.; Li, G.-Y.; Zheng, Z.-G.; Gao, Y.; Pan, J.-H.; Wang, F.; Huang, W.-Y.; Ge, Y.; Zhong, G.-E.; Tong, J. 2021: Effect of electroacupuncture on small airway function in patients with stable chronic obstructive pulmonary disease Zhongguo Zhen Jiu 41(8): 861-865
Li, Y.; Li, X.-Y.; Yuan, L.-R.; Wang, H.-L.; Pang, M. 2021: Evaluation of small airway function and its application in patients with chronic obstructive pulmonary disease (Review) Experimental and Therapeutic Medicine 22(6): 1386
Zhang, M.; Li, Q.; Zhang, X.-Y.; Ding, X.; Zhu, D.; Zhou, X. 2010: Relevance of lower airway bacterial colonization, airway inflammation, and pulmonary function in the stable stage of chronic obstructive pulmonary disease European Journal of Clinical Microbiology and Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 29(12): 1487-1493
Watanabe, S.; Renzetti, A.D.; Bigler, A. 1972: Bronchodilator and corticosteroid effects on regional and total airway resistance in patients with asthma, chronic bronchitis, and chronic pulmonary emphysema American Review of Respiratory Disease 106(3): 392-403
Satake, T.; Hara, M.; Ishikawa, H.; Ryuge, K.; Ishikawa, Y. 1972: Relationship between morphological changes and pulmonary function tests in chronic bronchitis and chronic pulmonary emphysema Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 61(1): 32-41
Zhao, N.; Wu, F.; Peng, J.; Zheng, Y.; Tian, H.; Yang, H.; Deng, Z.; Wang, Z.; Li, H.; Wen, X.; Xiao, S.; Huang, P.; Dai, C.; Lu, L.; Zhou, K.; Chen, S.; Zhou, Y.; Ran, P. 2022: Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity Respiratory Research 23(1): 298
Abdo, M.; Watz, H.; Trinkmann, F.; Bohnet, S.; Guess, M.A.M.; Roeben, J.; May, K.; Reck, M.; Bollmann, B.-A.; Stiebeler, S.; Dettmer, S.; Waschki, B.; Rabe, K.F.; Franzen, K.F.; Vogel-Claussen, J. 2025: Oscillometry-defined Small Airway Dysfunction in Tobacco-exposed Adults with Impaired or Preserved Airflow American Journal of Respiratory and Critical Care Medicine 2025