Cough, bloody sputum, eosinophil elevation and lung shadow
Li, Y.H.; Luo, J.M.; Zhang, T.; Gao, L.; Song, L.; Peng, M.; Liu, H.R.; Xu, W.B.; Liu, Z.Y.; Shi, J.H.; Feng, R.
Zhonghua Jie he He Hu Xi Za Zhi 45(12): 1231-1236
2022
ISSN/ISBN: 1001-0939 PMID: 36480855 Accession: 080712542
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Summary
患者男，47岁，间断咳嗽、咳痰2年，加重伴右侧胸痛、血痰3个月入院。患者入院前2年（2014年）出现咳嗽、咳白痰、轻微胸痛，查胸部CT提示右上肺2 cm×2 cm圆形低密度结节，未治疗，两周后症状缓解。入院前3个月奔跑追赶机动车后出现咳嗽、咳白黏痰、胸痛，咯暗红色血痰。体检未发现异常。白细胞计数正常，嗜酸性粒细胞百分比 42.61%，胸部CT示右上肺结节3.4 cm×3.3 cm，较前增大。双肺多发斑片影，以右肺上叶及左肺下叶为重，病变沿支气管血管束分布。入院后行CT引导下经皮肺穿刺，穿刺标本细菌、真菌及抗酸染色均阴性，HE染色可见纤维板层样的囊壁，壁内多发细粒棘球绦虫头节，囊壁外侧为纤维素样坏死和嗜酸性粒细胞浸润，诊断肺包虫病，建议抗包虫治疗，患者因无自觉症状，未服药物。已随访5年，复查CT肺内团块影缩小。.References
Li, A.M.; Lex, C.; Zacharasiewicz, A.; Wong, E.; Erin, E.; Hansel, T.; Wilson, N.M.; Bush, A. 2003: Cough frequency in children with stable asthma: correlation with lung function, exhaled nitric oxide, and sputum eosinophil count Thorax 58(11): 974-978Han, Y.; Guan, W.; Zhao, L.; Liu, M.; Zhou, G.; Ren, Y.; Dai, H. 2023: A 56-Year-Old man with Cough, Bloody Sputum, and Lithoptysis Chest 163(6): E255-E258
Yoo, Y.; Koh, Y.Y.; Kang, H.; Yu, J.; Nah, K.M.; Kim, C.K. 2004: Sputum eosinophil counts and eosinophil cationic protein levels in cough-variant asthma and in classic asthma, and their relationships to airway hypersensitivity or maximal airway response to methacholine Allergy 59(10): 1055-1062
Louis, R.; Shute, J.; Quaden, C.; Cataldo, D.; Radermecker, M.; Djukanovic, R. 1998: Effect of inhaled corticosteroids on sputum eosinophil counts and sputum eosinophil chemotactic factors in mild to moderate steroid naive asthmatics European Respiratory Journal 12(Suppl 28): 437S
Kradin, R.L.; Mark, E.J. 2002: Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-2002. A 48-year-old man with a cough and bloody sputum New England Journal of Medicine 346(24): 1892-1899
Farago, E.; Orosi, P. 1988: Eosinophil cells in sputum in lung cancer European Respiratory Journal 1(Suppl 2): 353S
Ho, T.; Scallan, C.; Rezaee, N.; Hambly, N.; Cox, P.G.; Kolb, M.; Nair, P. 2020: Sputum quantitative cytometry in patients with interstitial lung disease and chronic cough Respiratory Medicine 170: 106067
Virchow J C.Jr; Venge, P.; Virchow, C.Sr 1991: Eosinophil cationic protein in sputum from asthmatic patients with sputum eosinophilia American Review of Respiratory Disease 143(4 Part 2): A41
Paciência, I.ês.; Rocha, A.R.; Farraia, M.; Sokhatska, O.; Delgado, L.ís.; Couto, M.; Moreira, A. 2022: Eosinophil cationic protein (ECP) correlates with eosinophil cell counts in the induced sputum of elite swimmers Porto Biomedical Journal 7(2): E155
Lou, F.D.; Xing, Z.H. 1988: A 48-year-old woman with large mass shadow in the right lower lung with cough, chest pain and fever Chinese Medical Journal 101(9): 695-699
Yamada, H.; Yamaguchi, M.; Yamamoto, K.; Nakajima, T.; Hirai, K.; Morita, Y.; Sano, Y.; Yamada, H. 2000: Eotaxin in induced sputum of asthmatics: Relationship with eosinophils and eosinophil cationic protein in sputum Allergy 55(4): 392-397
Aizawa, H.; Iwanaga, T.; Inoue, H.; Takata, S.; Matsumoto, K.; Takahashi, N.; Yoshida, M.; Hara, N. 2000: Once-daily theophylline reduces serum eosinophil cationic protein and eosinophil levels in induced sputum of asthmatics International Archives of Allergy and Immunology 121(2): 123-128
Baraldi, E.; Maestrelli, P.; Semenzato, R.; Bertin, T.; Ongaro, R.; Azzolin, N.; Daria, C.; Plebani, M.; Fabbri, L.M.; Zacchello, F. 1997: Comparison of exhaled no values, eosinophil counts in the induced sputum and eosinophil cationic protein in asthmatic children European Respiratory Journal Suppl 10(25): 158S
Fireman, E.; Shtark, M.; Priel, I.E.; Shiner, R.; Mor, R.; Kivity, S.; Fireman, Z. 2007: Hydrogen peroxide in exhaled breath condensate (EBC) vs eosinophil count in induced sputum (IS) in parenchymal vs airways lung diseases Inflammation 30(1-2): 44-51
Pham, D.D.; Lee, J.-H.; Kim, J.-Y.; An, J.; Song, W.-J.; Kwon, H.-S.; Cho, Y.S.; Kim, T.-B. 2022: Different Impacts of Blood and Sputum Eosinophil Counts on Lung Function and Clinical Outcomes in Asthma: Findings from the COREA Cohort Lung 200(6): 697-706
Hong, C.S.; Park, J.W.; Park, Y.B. 1997: Eosinophil percentage and eosinophil cationic protein concentration of induced sputum for the assessment of airway inflammation in bronchial asthma Journal of Allergy and Clinical Immunology 99(1 Part 2): S375
Belda, J.; Giner, J.; Casan, P.; Sanchis, J. 1996: Eosinophil counts and eosinophil cationic protein levels in induced sputum from stable moderate asthma A prospective study European Respiratory Journal Suppl 9(23): 88S-89S
Louis, R.; Bettiol, J.; Cataldo, D.; Sele, J.; Henquet, M.; Radermecker, M. 2000: Effect of a 4-week treatment with theophylline on sputum eosinophilia and sputum eosinophil chemotactic activity in steroid-naive asthmatics Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 30(8): 1151-1160
Oohashi, Y.; Motojima, S.; Kushima, A.; Tateishi, K.; Fukuda, T.; Makino, S. 1991: Eosinophil activation in acute asthma attacks evaluated by electronmicroscopic findings of eosinophils and the concentration of eosinophil cationic protein in sputum Arerugi 40(10): 1265-1271
Park, J.W.; Whang, Y.W.; Kim, C.W.; Park, Y.B.; Hong, C.S. 1998: Eosinophil count and eosinophil cationic protein concentration of induced sputum in the diagnosis and assessment of airway inflammation in bronchial asthma Allergy and Asthma Proceedings 19(2): 61-67