Molecular targets that sensitize cancer to radiation killing: from the bench to the bedside

Sriramulu, S.; Thoidingjam, S.; Brown, S.L.; Siddiqui, F.; Movsas, B.; Nyati, S.; Sriramulu, S; Thoidingjam, S; Brown, S.L; Siddiqui, F; Movsas, B; Nyati, S

doi:10.1016/j.biopha.2022.114126

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Molecular targets that sensitize cancer to radiation killing: from the bench to the bedside

Sriramulu, S.; Thoidingjam, S.; Brown, S.L.; Siddiqui, F.; Movsas, B.; Nyati, S.

Biomedicine and PharmacoTherapy 158: 114126

2023

ISSN/ISBN: 0753-3322

PMID: 36521246

DOI: 10.1016/j.biopha.2022.114126
Accession: 080730428

Article/Abstract emailed within 0-6 h

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Summary

Radiotherapy is a standard cytotoxic therapy against solid cancers. It uses ionizing radiation to kill tumor cells through damage to DNA, either directly or indirectly. Radioresistance is often associated with dysregulated DNA damage repair processes. Most radiosensitizers enhance radiation-mediated DNA damage and reduce the rate of DNA repair ultimately leading to accumulation of DNA damages, cell-cycle arrest, and cell death. Recently, agents targeting key signals in DNA damage response such as DNA repair pathways and cell-cycle have been developed. This new class of molecularly targeted radiosensitizing agents is being evaluated in preclinical and clinical studies to monitor their activity in potentiating radiation cytotoxicity of tumors and reducing normal tissue toxicity. The molecular pathways of DNA damage response are reviewed with a focus on the repair mechanisms, therapeutic targets under current clinical evaluation including ATM, ATR, CDK1, CDK4/6, CHK1, DNA-PKcs, PARP-1, Wee1, & MPS1/TTK and potential new targets (BUB1, and DNA LIG4) for radiation sensitization.

Molecular targets that sensitize cancer to radiation killing: from the bench to the bedside

Sriramulu, S.; Thoidingjam, S.; Brown, S.L.; Siddiqui, F.; Movsas, B.; Nyati, S.

Biomedicine and PharmacoTherapy 158: 114126

2023

Article/Abstract emailed within 0-6 h

Summary

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