Continuous-flow difluoromethylation with chlorodifluoromethane under biphasic conditions
Gutmann, B.; Hanselmann, P.; Bersier, M.; Roberge, D.; Kappe, C.O.
Journal of Flow Chemistry 7(2): 46-51
2017
ISSN/ISBN: 2062-249X DOI: 10.1556/1846.2017.00005
Accession: 082674441
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References
Yu, C.; Su, J.; Ma, X.; Zhou, Y.; Song, Q. 2019: Difluoromethylation of Tosylhydrazone Compounds with Chlorodifluoromethane under Mild Conditions Asian Journal of Organic Chemistry 8(5): 694-697Nawrot, E.; Jończyk, A. 2009: Difluoromethylation of some C–H acids with chlorodifluoromethane under conditions of phase transfer catalysis (PTC) Journal of Fluorine Chemistry 130(5): 466-469
Pelc, M.; Huang, W.; Trujillo, J.; Baldus, J.; Turner, S.; Kleine, P.; Yang, S.; Thorarensen, A. 2010: An Efficient and Regioselective Difluoromethylation of 3-Iodoindazole with Chlorodifluoromethane Synlett 2010(2): 219-222
Xu, C.; Guo, W-Hao.; He, X.; Guo, Y-Long.; Zhang, X-Ying.; Zhang, X. 2018: Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel Nature Communications 9(1): 1170
Grunwald, E.; Liu, S.H.; Lonzetta, C.M. 1982: Time lags and V-V' steady states in the infrared laser induced decomposition of chlorodifluoromethane and chlorodifluoromethane-d1 under collisional conditions Journal of the American Chemical Society 104(11): 3014-3021
Köckinger, M.; Ciaglia, T.; Bersier, M.; Hanselmann, P.; Gutmann, B.; Kappe, C.O. 2018: Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids Green Chemistry 20(1): 108-112
Zani, D.D.; Colombo, M. 2012: Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols Journal of Flow Chemistry 2(1): 5-7
Okada, M.; Uematsu, M.; Watanabe, K. 1986: Orthobaric liquid densities of trichlorofluoromethane, dichlorodifluoromethane, chlorodifluoromethane, 1,1,2-trichlorotrifluoroethane, 1,2-dichlorotetrafluoroethane, and of the azeotropic mixture of (chlorodifluoromethane + chloropentafluoroethane) between 203 and 463 K The Journal of Chemical Thermodynamics 18(6): 527-543
Okada, M.; Uematsu, M.; Watanabe, K. 1986: Orthobaric liquid densities of trichloro-fluoromethane, dichlorodifluoromethane, chlorodifluoromethane, 1,1,2-trichlorotrifluoroethane, 1,2-dichlorotetrafluoroethane, and of the azeotropic mixture of (chlorodifluoromethane+chloropentafluoroethane).. Journal of Chemical Thermodynamics 18(6): 527-543
Wang, S.; Patehebieke, Y.; Zhou, Z.; Zhang, Z.; Wang, X. 2020: Catalyst-free biphasic oxidation of Thiophenes in continuous-flow Journal of Flow Chemistry 10(4): 597-603
Volk, A.A.; Epps, R.W.; Yonemoto, D.; Castellano, F.N.; Abolhasani, M. 2021: Continuous biphasic chemical processes in a four-phase segmented flow reactor Reaction Chemistry-Engineering 6(8): 1367-1375
Baier, B.; Jodicke, T.; Harms, J.; Luck, M.; Muke, O.; Kruger, E. 1992: Anwendung der Continuous Flow Analysentechnik zur Qualitätskontrolle in der Brauindustrie. III : Einsatz der Continuous Flow Analytik zur Bestimmung des Gesamtpolyphenolgehaltes in Würze und Bier - Application of the continuous flow analysis technique for quality control in the brewing industry. III: Use of continuous flow analysis to determine the total polyphenol content in wort and beer Monatsschrift für Brauwissenschaft 45(6): 204-210
Sagandira, M.B.; Sagandira, C.R.; Watts, P. 2021: Continuous flow synthesis of xylidines via biphasic nitration of xylenes and nitro-reduction Journal of Flow Chemistry 11(2): 193-208
Evangelia Perperi; Yulin Huang; Panagiota Angeli; George Manos; David, J. Cole-Hamilton 2004: Separation studies in a continuous flow fluorous biphasic system: Proof of concept Journal of Molecular Catalysis A: Chemical 221(1-2): 19-27
Polley, A.; Bairy, G.; Das, P.; Jana, R. 2018: Triple Mode of Alkylation with Ethyl Bromodifluoroacetate: N , or O ‐Difluoromethylation, N ‐Ethylation and S ‐(ethoxycarbonyl)difluoromethylation Advanced Synthesis-Catalysis 360(21): 4161-4167
He, Z.; Hu, M.; Luo, T.; Li, L.; Hu, J. 2012: Copper-catalyzed difluoromethylation of β,γ-unsaturated carboxylic acids: an efficient allylic difluoromethylation Angewandte Chemie 51(46): 11545-11547
Huang, Y.; Lin, Z.; Chen, Y.; Fang, S.; Jiang, H.; Wu, W. 2019: Transition-metal-free N-difluoromethylation of hydrazones with TMSCF2Br as the difluoromethylation reagent Organic Chemistry Frontiers 6(14): 2462-2466
Reymond, H.; Vitas, S.; Vernuccio, S.; von Rohr, P.R. 2017: Reaction Process of Resin-Catalyzed Methyl Formate Hydrolysis in Biphasic Continuous Flow Industrial-Engineering Chemistry Research 56(6): 1439-1449
Webb, P.B.; Sellin, M.F.; Kunene, T.E.; Williamson, S.; Slawin, A.M.Z.; Cole-Hamilton, D.J. 2003: Continuous flow hydroformylation of alkenes in supercritical fluid-ionic liquid biphasic systems Journal of the American Chemical Society 125(50): 15577-15588
Souzanchi, S.; Nazari, L.; Venkateswara Rao, K.T.; Yuan, Z.; Tan, Z.; Charles Xu, C. 2021: Catalytic dehydration of glucose to 5-HMF using heterogeneous solid catalysts in a biphasic continuous-flow tubular reactor Journal of Industrial and Engineering Chemistry 101: 214-226